Abnormalities of cAMP signaling in affective disorders: implications for pathophysiology and treatment

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments

1995 • 2,090 citations

'Vascular Depression' Hypothesis

1997 • 1,759 citations

The Relationship of Depression to Cardiovascular Disease

1998 • 1,560 citations

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

1996 • 1,200 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 842 citations

Depression Is a Risk Factor for Coronary Artery Disease in Men

1998 • 589 citations

Exaggerated platelet reactivity in major depression

1996 • 575 citations

Neurotrophins and depression

1999 • 538 citations

Protein Phosphorylation and Neuronal Function

1985 • 525 citations

The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS

1999 • 495 citations

Initiation and adaptation: a paradigm for understanding psychotropic drug action

1996 • 489 citations

Cyclic nucleotide-dependent protein kinases

1991 • 487 citations

Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3

1997 • 459 citations

Tailoring cAMP-signalling responses through isoform multiplicity

1997 • 437 citations

The Mood‐Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase‐3

2000 • 434 citations

Molecular mechanisms of theprotein serine/threonine phosphatases

1996 • 365 citations

Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.

1991 • 338 citations

Signal Transduction Pathways

1995 • 328 citations

Lithium inhibits Alzheimer's disease‐like tau protein phosphorylation in neurons

1997 • 315 citations

G protein regulation of adenylate cyclase

1999 • 231 citations

Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus.

1990 • 203 citations

Lithium and brain signal transduction systems

1994 • 200 citations

Chronic Antidepressant Administration Alters the Subcellular Distribution of Cyclic AMP‐Dependent Protein Kinase in Rat Frontal Cortex

1989 • 196 citations

Chronic Antidepressant Administration Increases the Expression of cAMP-Specific Phosphodiesterase 4A and 4B Isoforms

1999 • 175 citations

Enhanced protein kinase C activity and translocation in bipolar affective disorder brains

1996 • 166 citations

Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder

1997 • 155 citations

CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia

1993 • 147 citations

High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder

1997 • 145 citations

Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims

1994 • 136 citations

Neurobiology of lithium: an update.

1998 • 130 citations

Receptor‐Mediated Activation of G Proteins Is Increased in Postmortem Brains of Bipolar Affective Disorder Subjects

1996 • 128 citations

The Phosphoinositide Signal Transduction System Is Impaired in Bipolar Affective Disorder Brain

1996 • 126 citations

The Ways in Which Hormones Change Cyclic Adenosine 3′,5′-Monophosphate-Dependent Protein Kinase Subunits, and How Such Changes Affect Cell Behavior*

1993 • 113 citations

Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus.

1995 • 111 citations

Reduced [³H]Cyclic AMP Binding in Postmortem Brain from Subjects with Bipolar Affective Disorder

1997 • 107 citations

cAMP-dependent protein kinase activity in major depression

1996 • 105 citations

cAMP-dependent phosphorylation of soluble and crude microtubule fractions of rat cerebral cortex after prolonged desmethylimipramine treatment

1989 • 102 citations

A bimodal model of the mechanism of action of lithium

1999 • 95 citations

Lithium ion inhibits nerve growth factor-induced neurite outgrowth and phosphorylation of nerve growth factor-modulated microtubule-associated proteins.

1985 • 85 citations

Attenuation of Cyclic AMP Production by Carbamazepine

1996 • 83 citations

Tissue and Subcellular Distributions of the smg-21/rap1/ Krev-1 Proteins Which Are Partly Distinct from Those of c-ras p21s

1990 • 77 citations

Effects of chronic lithium treatment on protein kinase c and cyclic AMP-dependent protein phosphorylation

1991 • 75 citations

cAMP binding proteins in the rat cerebral cortex after administration of selective 5-HT and NE reuptake blockers with antidepressant activity.

1991 • 72 citations

Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells: a property of protein kinase C-mediated mood stabilizers.

1998 • 69 citations

Lithium stimulates gene expression through the AP-1 transcription factor pathway

1998 • 69 citations

Myristoylated alanine-rich C kinase substrate (MARCKS): a molecular target for the therapeutic action of mood stabilizers in the brain?

1996 • 69 citations

Role of rap1B and p21ras GTPase-activating protein in the regulation of phospholipase C-gamma 1 in human platelets.

1992 • 68 citations

Abnormalities of Cyclic Adenosine Monophosphate Signaling in Platelets From Untreated Patients With Bipolar Disorder

1999 • 67 citations

Regulation of signal transduction pathways by mood-stabilizing agents: implications for the delayed onset of therapeutic efficacy.

1996 • 66 citations

Selective Increases in Phosphoinositide Signaling Activity and G Protein Levels in Postmortem Brain from Subjects with Schizophrenia or Alcohol Dependence

1998 • 65 citations

Protein kinase C in rat brain cortex and hippocampus: effect of repeated administration of fluoxetine and desipramine

1995 • 65 citations

Lithium Increases Tyrosine Hydroxylase Levels Both In Vivo and In Vitro

1998 • 64 citations

High levels of Gs alpha in platelets of euthymic patients with bipolar affective disorder

1997 • 61 citations

Presynaptic Ca2+/calmodulin-dependent protein kinase II: autophosphorylation and activity increase in the hippocampus after long-term blockade of serotonin reuptake.

1995 • 59 citations

Intracellular phosphatidylinositol pathway abnormalities in bipolar disorder patients.

1997 • 53 citations

Abnormalities of cAMP-dependent endogenous phosphorylation in platelets from patients with bipolar disorder

1995 • 53 citations

Altered protein phosphorylation in the rat brain following chronic lithium and carbamazepine treatments

1997 • 52 citations

Potentiation of Astroglial Nitric Oxide Synthase Type‐2 Expression by Lithium Chloride

1998 • 51 citations

No Abnormality in the Gene for the G Protein Stimulatory α Subunit in Patients With Bipolar Disorder

1997 • 50 citations

New Biochemical Hypotheses on the Mechanism of Action of Antidepressant Drugs: cAMP - Dependent Phosphorylation System

1992 • 49 citations

Forskolin-stimulated platelet adenylyl cyclase activity is lower in persons with major depression

1997 • 48 citations

Effect of protein kinase A on inositide metabolism and rap 1 G-protein in human erythroleukemia cells.

1990 • 47 citations

Abnormal G protein αs- and αi2-subunit mRNA expression in bipolar affective disorder

1998 • 45 citations

The Effects of Seasons and Light Therapy on G Protein Levels in Mononuclear Leukocytes of Patients With Seasonal Affective Disorder

1999 • 44 citations

Protein kinase C in platelets of depressed patients

1998 • 44 citations

Chronic Administration of Lithium or Other Antidepressants Increases Levels of DARPP‐32 in Rat Frontal Cortex

1992 • 41 citations

Chronic Administration of Lithium Chloride Increases Immunodetectable Glial Fibrillary Acidic Protein in the Rat Hippocampus

1994 • 41 citations

Increase in [3H]cAMP binding sites and decrease in Giα and Goα immunoreactivities in left temporal cortices from patients with schizophrenia

1993 • 40 citations

Tissue and subcellular distributions of the smg-21/rap1/Krev-1 proteins which are partly distinct from those of c-ras p21s.

1990 • 39 citations

β-Adrenoceptor-Linked Protein Kinase A (PKA) Activity in Human Fibroblasts from Normal Subjects and from Patients with Major Depression

1996 • 38 citations

Second messenger systems and mood disorders

1996 • 37 citations

Long Term Blockade of Serotonin Reuptake Affects Synaptotagmin Phosphorylation in the Hippocampus

1997 • 36 citations

Evidence for a role of rap1 protein in the regulation of human platelet Ca2+ fluxes

1992 • 36 citations

Effects of Lithium on cAMP-Dependent Protein Kinase in Rat Brain

1998 • 35 citations

cAMP-dependent phosphorylation system after short and long-term administration of moclobemide

1998 • 32 citations

Differential effects of lithium on platelet protein phosphorylation in bipolar patients and healthy subjects

1997 • 31 citations

Brain [3H]cAMP binding sites are unaltered in depressed suicides, but decreased by antidepressants

1997 • 28 citations

Effects of long-term treatment with desipramine on microtubule proteins in rat cerebral cortex

1997 • 27 citations

Effects of imipramine and sertraline on protein kinase activity in rat frontal cortex

1998 • 27 citations

Inhibitory effect of lithium on cAMP dependent phosphorylation system

1996 • 26 citations

Effects of fluvoxamine on the protein phosphorylation system associated with rat neuronal microtubules

1995 • 25 citations

Lithium Chloride Inhibits the Phosphorylation of Newly Synthesized Neurofilament Protein, NF‐M, in Cultured Chick Sensory Neurons

1991 • 24 citations

Chronic Imipramine Administration Alters the Activity and Phosphorylation State of Tyrosine Hydroxylase in Dopaminergic Regions of Rat Brain

1995 • 22 citations

Signal Transduction by Platelet Adenylate Cyclase: Alterations in Depressed Patients May Reflect Impairment in the Coordinated Integration of Cellular Signals (Coincidence Detection) 11This work was presented in part at the Annual Meeting of the American Psychiatric Association, New York, NY, May 7, 1996.

1998 • 19 citations

Antidepressants and protein kinases: Desipramine treatment affects pineal gland cAMP-dependent protein kinase activity

1986 • 17 citations

Subsensitivity of adenylyl cyclase-coupled receptors on mononuclear leukocytes from drug-free inpatients with a major depressive episode

1997 • 15 citations

G-Protein Level Quantification in Platelets and Leukocytes from Patients with Panic Disorder

1996 • 15 citations

Rap proteins: investigating their role in cell function.

1992 • 14 citations

Evidence for the existence of cAMP-dependent protein kinase phosphorylation system associated with specific phosphoproteins in stable microtubules from rat cerebral cortex

1993 • 13 citations

Time-course changes in rat cerebral cortex subcellular distribution of the cyclic-AMP binding after treatment with selective serotonin reuptake inhibitors

1998 • 12 citations

Protein phosphorylation in rat cerebral cortex after desipramine treatment

1987 • 2 citations