Hepatitis B virus X protein inhibits nucleotide excision repair

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

1995 • 365 citations

Functional inactivation but not structural mutation of p53 causes liver cancer

1995 • 364 citations

Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

1997 • 322 citations

Abrogation of p53-Induced Apoptosis by the Hepatitis B Virus X Gene

2003 • 318 citations

Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma.

1993 • 307 citations

The Genetic Basis of Human Cancer

1998 • 305 citations

Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls.

1995 • 286 citations

Hepatitis B Virus X Protein Interferes with Cellular DNA Repair

1998 • 272 citations

Hepatitis B virus X protein interacts with a probable cellular DNA repair protein

1995 • 249 citations

Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma.

1997 • 228 citations

Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations.

1996 • 172 citations

Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH.

1996 • 137 citations

Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells

1997 • 83 citations

Biochemical and molecular epidemiology of human cancer: indicators of carcinogen exposure, DNA damage, and genetic predisposition.

1987 • 80 citations

Monoclonal Antibody-Directed Radioimmunoassay Detects Cytochrome P-450 in Human Placenta and Lymphocytes

1985 • 56 citations

Hepatitis B Virus X-Protein Binds Damaged DNA and Sensitizes Liver Cells to Ultraviolet Irradiation

1997 • 51 citations

Interactive Effects of p53 Tumor Suppressor Gene and Hepatitis B Virus in Hepatocellular Carcinogenesis

1997 • 5 citations