The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21CIP1/Waf1

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Expression of a large family of POU-domain regulatory genes in mammalian brain development

1989 • 828 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development

1996 • 745 citations

POU domain family values: flexibility, partnerships, and developmental codes.

1997 • 481 citations

Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor

1981 • 407 citations

POU domain transcription factors

1993 • 278 citations

Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons

1996 • 257 citations

Novel cell lines display properties of nociceptive sensory neurons

1990 • 256 citations

Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling.

1996 • 237 citations

Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors

1995 • 223 citations

p53 Plays a Regulatory Role in Differentiation and Apoptosis of Central Nervous System-Associated Cells

1996 • 199 citations

Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs.

1993 • 193 citations

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

1995 • 193 citations

p53 Suppresses the Activation of the Bcl-2 Promoter by the Brn-3a POU Family Transcription Factor

1999 • 146 citations

Apoptosis in Neurological Disease

1998 • 126 citations

Bcl-2 Transcription from the Proximal P2 Promoter Is Activated in Neuronal Cells by the Brn-3a POU Family Transcription Factor

1998 • 122 citations

A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells

1992 • 115 citations

Contribution of p53-Dependent Caspase Activation to Neuronal Cell Death Declines with Neuronal Maturation

1999 • 111 citations

Defects in Sensory Axon Growth Precede Neuronal Death in Brn3a-Deficient Mice

2001 • 99 citations

Cycloheximide phase-shifts, but does not prevent, de novo Krox-24 protein expression

1997 • 74 citations

Regulation of Neurite Outgrowth and SNAP-25 Gene Expression by the Brn-3a Transcription Factor

1995 • 73 citations

Activation of the α-Internexin Promoter by the Brn-3a Transcription Factor Is Dependent on the N-terminal Region of the Protein

1995 • 67 citations

The Brn-3a Transcription Factor Induces Neuronal Process Outgrowth and the Coordinate Expression of Genes Encoding Synaptic Proteins

1997 • 64 citations

The BRN-3A Transcription Factor Protects Sensory but Not Sympathetic Neurons from Programmed Cell Death/Apoptosis

2001 • 58 citations

Growth factor synergism and antagonism in early neural crest development

1998 • 58 citations

Coordinate Induction of the Three Neurofilament Genes by the Brn-3a Transcription Factor

1997 • 57 citations

6 Molecular Regulation of Neuronal Apoptosis

1998 • 56 citations

Brn-3a Activates the Expression of Bcl-xL and Promotes Neuronal Survival in Vivo as Well as in Vitro

2001 • 48 citations

The DNA target site for the Brn-3 POU family transcription factors can confer responsiveness to cyclic AMP and removal of serum in neuronal cells

1994 • 41 citations

Heat Shock Protein-56 is Induced by Cardiotrophin-1 and Mediates its Hypertrophic Effect

2001 • 18 citations