Identification of BARD1 as Mediator between Proapoptotic Stress and p53-Dependent Apoptosis

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Regulation of p53 in response to DNA damage

1999 • 960 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

1996 • 734 citations

In search of the tumour-suppressor functions of BRCA1 and BRCA2

2000 • 638 citations

The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation

2001 • 623 citations

The cellular response to p53: the decision between life and death

1999 • 594 citations

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

1999 • 558 citations

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

1997 • 537 citations

Ubiquitination: RING for destruction?

2000 • 496 citations

Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

2000 • 383 citations

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis

2001 • 359 citations

Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells

1995 • 231 citations

The BARD1-CstF-50 Interaction Links mRNA 3′ End Formation to DNA Damage and Tumor Suppression

2001 • 210 citations

TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution.

2001 • 201 citations

Functional Interaction of BRCA1-Associated BARD1 with Polyadenylation Factor CstF-50

1999 • 194 citations

Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers

1998 • 179 citations

BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines

2000 • 148 citations

Mapping the Functional Domains of BRCA1

1999 • 138 citations

BRCA1 Is a Selective Co-activator of 14-3-3ς Gene Transcription in Mouse Embryonic Stem Cells

2001 • 100 citations

In Vitro Repression of Brca1-associated RING Domain Gene, Bard1, Induces Phenotypic Changes in Mammary Epithelial Cells

1998 • 92 citations

Abnormal expression of BRCA1 and BRCA1-interactive DNA-repair proteins in breast carcinomas

2000 • 92 citations

Developmental studies of Brca1 and Brca2 knock-out mice.

1998 • 84 citations

P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells

1999 • 73 citations

Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein

1998 • 37 citations

Molecular modeling of the amino-terminal zinc ring domain of BRCA1.

1996 • 35 citations

The p53 mutational spectrum associated with BRCA1 mutant ovarian cancer.

2001 • 31 citations

Identification of an apoptotic cleavage product of BARD1 as an autoantigen: a potential factor in the antitumoral response mediated by apoptotic bodies.

2000 • 31 citations

Antisense Inhibition of BRCA1 Expression and Molecular Analysis of Hereditary Tumors Indicate That Functional Inactivation of the p53 DNA Damage Response Pathway Is Required for BRCA-Associated Tumorigenesis

2001 • 19 citations

Ultrastructure of the normal menstrual cycle: A review

1993 • 5 citations