Dual action of glatiramer acetate (Cop-1) in the treatment of CNS autoimmune and neurodegenerative disorders

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

1999 • 881 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Nitric oxide, mitochondria and neurological disease

1999 • 474 citations

Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences

2001 • 470 citations

Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide

1971 • 431 citations

Neurodegenerative disorders: the role of peroxynitrite

1999 • 414 citations

Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis

2000 • 412 citations

Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes

2000 • 393 citations

Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells

2001 • 392 citations

Passive or Active Immunization with Myelin Basic Protein Promotes Recovery from Spinal Cord Contusion

2000 • 368 citations

Regulation of Experimental Autoimmune Encephalomyelitis by Natural Killer (NK) Cells

1997 • 360 citations

Protective Autoimmunity Is a Physiological Response to CNS Trauma

2001 • 349 citations

The link between excitotoxic oligodendroglial death and demyelinating diseases

2001 • 345 citations

T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies

2000 • 312 citations

Multiple sclerosis: Comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells

2000 • 304 citations

Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: Implications for glaucoma

2001 • 293 citations

Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells.

1982 • 261 citations

Mechanisms of action of glatiramer acetate in multiple sclerosis

2001 • 252 citations

Concept of autoimmunity following spinal cord injury: Possible roles for T lymphocytes in the traumatized central nervous system

1996 • 248 citations

Mitochondrial dysfunction in Parkinson's disease

1999 • 245 citations

Therapeutic inhibition of the complement system.

1998 • 242 citations

Diffuse prolonged depression of cerebral oxidative metabolism following concussive brain injury in the rat: a cytochrome oxidase histochemistry study

1991 • 241 citations

Acute Neuronal Apoptosis in a Rat Model of Multiple Sclerosis

2001 • 233 citations

Neuronal Survival after CNS Insult Is Determined by a Genetically Encoded Autoimmune Response

2001 • 231 citations

Degeneration of Spared Axons Following Partial White Matter Lesion: Implications for Optic Nerve Neuropathies

1998 • 214 citations

Autoimmunity can benefit self-maintenance

2000 • 190 citations

Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1

1998 • 176 citations

Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.

1995 • 174 citations

Genetic models for CNS inflammation

2001 • 168 citations

Experimental neurobiology of central nervous system trauma.

1993 • 167 citations

Protective autoimmunity: regulation and prospects for vaccination after brain and spinal cord injuries

2001 • 164 citations

Vaccination for Neuroprotection in the Mouse Optic Nerve: Implications for Optic Neuropathies

2001 • 156 citations

Copolymer 1 inhibits chronic relapsing experimental allergic encephalomyelitis induced by proteolipid protein (PLP) peptides in mice and interferes with PLP-specific T cell responses

1996 • 155 citations

Excitotoxicity and neurodegeneration in amyotrophic lateral sclerosis.

1995 • 153 citations

Treatment of multiple sclerosis with Copaxone (COP): Elispot assay detects COP-induced interleukin-4 and interferon-gamma response in blood cells

2001 • 115 citations

Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7–2 (CD86) and prevention of cyst formation

2001 • 111 citations

Differential regulation of trophic factor receptor mRNAs in spinal motoneurons after sciatic nerve transection and ventral root avulsion in the rat

2000 • 108 citations

Autoreactive T cells induce neurotrophin production by immune and neural cells in injured rat optic nerve: Implications for protective autoimmunity

2002 • 97 citations

Bromocriptine in rheumatic and autoimmune diseases

2001 • 97 citations

T suppressor hybridomas and interleukin‐2‐dependent lines induced by copolymer 1 or by spinal cord homogenate down‐regulate experimental allergic encephalomyelitis

1993 • 88 citations

Glia-T cell dialogue

2000 • 86 citations

Copolymer 1: from basic research to clinical application

1997 • 73 citations

Glatiramer acetate in the treatment of multiple sclerosis

2001 • 71 citations

Characterization of T cell lines derived from glatiramer-acetate-treated multiple sclerosis patients

2000 • 70 citations

p53 from basic research to clinical applications.

1992 • 67 citations

Axon damage and repair in multiple sclerosis

1999 • 66 citations

Therapeutic inhibition of the complement system. Y2K update

2000 • 55 citations

Multiple Sclerosis as a By-Product of the Failure to Sustain Protective Autoimmunity: A Paradigm Shift

2002 • 52 citations

Oral tolerance with Copolymer 1 for the treatment of multiple sclerosis

1999 • 50 citations

Multiple Sclerosis and Central Nervous System Demyelination

1999 • 44 citations

Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease

1997 • 39 citations

Binding of copolymer 1 and myelin basic protein leads to clustering of class II MHC molecules on antigen-presenting cells

1997 • 36 citations

Genetics of rat neuroinflammation

2000 • 35 citations

Degeneracy, as opposed to specificity, in immunotherapy

2002 • 33 citations

Beyond Intraocular Pressure: Neuroprotective Strategies for Future Glaucoma Therapy

2001 • 30 citations

Coadministration of Methylprednisolone with Hypertonic Saline Solution Improves Overall Neurological Function and Survival Rates in a Chronic Model of Spinal Cord Injury

2001 • 29 citations

Degeneracy, as opposed to specificity, in immunotherapy

2002 • 27 citations

Persistent expression of experimental autoimmune encephalomyelitis (EAE)-specific Vbeta8.2 TCR spectratype in the central nervous system of rats with chronic relapsing EAE.

1998 • 26 citations

Mechanisms of tissue injury in multiple sclerosis: opportunities for neuroprotective therapy

2000 • 25 citations

Intense immune suppression for systemic lupus--the role of hematopoietic stem cells.

2000 • 23 citations

Studies on kynurenine in human cerebrospinal fluid: Lowered levels in epilepsy

1983 • 23 citations

Persistent Expression of Experimental Autoimmune Encephalomyelitis (EAE)-Specific Vβ8.2 TCR Spectratype in the Central Nervous System of Rats with Chronic Relapsing EAE

1998 • 22 citations

EAE TCR Motifs and Antigen Recognition in Myelin Basic Protein-Induced Anterior Uveitis in Lewis Rats

1998 • 21 citations

Cop 1 as a candidate drug for multiple sclerosis

1997 • 15 citations

Immunosuppressive Applications of PHA and Other Plant Mitogens

1998 • 10 citations

Oral toleragens in rheumatoid arthritis.

2000 • 9 citations

Antigen and superantigen presentation in the human CNS

2000 • 8 citations

The myelin basic protein-specific T cell repertoire in Lewis rats: T cell receptor diversity is influenced both by intrathymic milieu and by extrathymic peptide presentation

1998 • 7 citations

Superantigen presenting capacity of human astrocytes

2000 • 7 citations