Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

Autoimmunity, microbial immunity and the immunological homunculus

1991 • 525 citations

Evidence for function of Ia molecules on gut epithelial cells in man.

1987 • 521 citations

The regulation of immune responses to dietary protein antigens

1987 • 489 citations

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.

1996 • 487 citations

Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.

1993 • 457 citations

Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy.

1991 • 450 citations

The clonal selection theory of acquired immunity

1960 • 396 citations

Immunosuppressive and Anti-inflammatory Properties of Interleukin 10

1995 • 385 citations

Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by Th3/Tr1-type cytokines IL-10 and transforming growth factor-β but not by a Th1 to Th2 shift

2000 • 365 citations

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

1998 • 359 citations

Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function.

1990 • 349 citations

Expanding Dendritic Cells In Vivo Enhances the Induction of Oral Tolerance

1998 • 327 citations

Oral Tolerance: Mechanisms and Therapeutic Applications

1999 • 318 citations

Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein

1988 • 291 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes.

1989 • 284 citations

Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo.

1993 • 284 citations

Regulatory T Cells in the Control of Autoimmunity: the Essential Role of Transforming Growth Factor β and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC− Cells and CD4+CD8− Thymocytes

1999 • 269 citations

Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells.

1986 • 252 citations

Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin

1993 • 233 citations

Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression.

1995 • 222 citations

IL-4 is a differentiation factor for transforming growth factor-β secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis

1998 • 218 citations

Enterically induced immunologic tolerance. I. Induction of suppressor T lymphoyctes by intragastric administration of soluble proteins.

1978 • 218 citations

TGF-beta promotes immune deviation by altering accessory signals of antigen-presenting cells.

1998 • 217 citations

Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production.

1998 • 205 citations

A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance.

1998 • 158 citations

Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression.

1993 • 158 citations

TGF-β Promotes Immune Deviation by Altering Accessory Signals of Antigen-Presenting Cells

1998 • 155 citations

Stigma Variations: Observations on Suppressor T Cells and Leprosy

1992 • 155 citations

Oral Tolerance to Myelin Basic Protein Induces Regulatory TGF-β-Secreting T Cells in Peyer's Patches of SJL Mice

1994 • 151 citations

Factors Involved in the Differentiation of TGF-β-Producing Cells from Naive CD4+ T Cells: IL-4 and IFN-γ Have Opposing Effects, While TGF-β Positively Regulates Its Own Production

1998 • 145 citations

In Situ Immune Response in Gut-Associated Lymphoid Tissue (GALT) Following Oral Antigen in TCR-Transgenic Mice

1998 • 145 citations

Immunological responses to fed protein antigens in mice. I. Reversal of oral tolerance to ovalbumin by cyclophosphamide.

1982 • 136 citations

Inhibition of specific immune responses by feeding protein antigens. IV. Evidence for tolerance and specific active suppression of cell-mediated immune responses to ovalbumin.

1979 • 131 citations

Activated Self-MHC-Reactive T Cells Have the Cytokine Phenotype of Th3/T Regulatory Cell 1 T Cells

2000 • 124 citations

On the mechanisms by which transforming growth factor‐β2 alters antigen‐presenting abilities of macrophages on T cell activation

1997 • 121 citations

Selective induction of Th2 cells in murine Peyer's patches by oral immunization

1992 • 118 citations

Enterically Induced Immunologic Tolerance

1978 • 117 citations

Immunological responses to fed protein antigens in mice. II. Oral tolerance for CMI is due to activation of cyclophosphamide-sensitive cells by gut-processed antigen.

1983 • 102 citations

Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-β1

1998 • 99 citations

B Cell-Deficient (μMT) Mice Have Alterations in the Cytokine Microenvironment of the Gut-Associated Lymphoid Tissue (GALT) and a Defect in the Low Dose Mechanism of Oral Tolerance

2001 • 99 citations

CTLA-4 is required for the induction of high dose oral tolerance

1998 • 97 citations

Regulation of antigen-specific IgE, IgG1, and mast cell responses to ingested allergen by mucosal tolerance induction.

1997 • 95 citations

Inhibition of Specific Immune Responses by Feeding Protein Antigens

1979 • 93 citations

Oral tolerance to ovalbumin in mice: studies of chemically modified and 'biologically filtered' antigen.

1986 • 90 citations

The distinctive specificity of antigen-specific suppressor T cells

1991 • 77 citations

Alterations in cytokine production following intraocular injection of soluble protein antigen: impairment in IFN-gamma and induction of TGF-beta and IL-4 production.

1998 • 68 citations

Lack of oral tolerance but oral priming for contact sensitivity to dinitrofluorobenzene in major histocompatibility complex class II‐deficient mice and in CD4⁺ T cell‐depleted mice

1996 • 68 citations

The role of small intestinal antigen‐presenting cells in the induction of T‐cell reactivity to soluble protein antigens: association between aberrant presentation in the lamina propria and oral tolerance

1996 • 64 citations

Oral tolerance to haptens: intestinal epithelial cells from 2,4-dinitrochlorobenzene-fed mice inhibit hapten-specific T cell activationin vitro

1995 • 55 citations

Prevention of lung eosinophilic inflammation by oral tolerance

1998 • 54 citations

Induction of oral tolerance in TGF-beta 1 null mice.

1998 • 54 citations

Alterations in Cytokine Production Following Intraocular Injection of Soluble Protein Antigen: Impairment in IFN-γ and Induction of TGF-β and IL-4 Production

1998 • 48 citations

Induction of Oral Tolerance in TGF-β1 Null Mice

1998 • 45 citations

Inactivation of Th1 and Th2 Cells by Feeding Ovalbumina

1996 • 39 citations

Inhibition of specific immune responses by feeding protein antigens. V. Induction of the tolerant state in the absence of specific suppressor T cells.

1982 • 38 citations

Immunosuppression caused by antigen feeding. I. Evidence for the activation of a feedback suppressor pathway in the spleens of antigen-fed mice

1982 • 37 citations

Oral administration of the contact sensitizer trinitrochlorobenzene: Initial sensitization and subsequent appearance of a suppressor population

1990 • 35 citations

Regulation of the primary in vitro response to TNP-polymerized ovalbumin by T suppressor cells induced by ovalbumin feeding.

1984 • 16 citations

Oral Tolerance Induced by Gut-Processed Antigen

1987 • 14 citations

FACS-Sorted Spleen and Peyer’s Patch Dendritic Cells Induce Different Responses in Th0 Clones

1997 • 9 citations