Differential regulation of trophic factor receptor mRNAs in spinal motoneurons after sciatic nerve transection and ventral root avulsion in the rat

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

Functions of the neurotrophins during nervous system development: What the knockouts are teaching us

1994 • 1,431 citations

The Trk family of neurotrophin receptors

1994 • 1,271 citations

GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle

1994 • 1,261 citations

Renal and neuronal abnormalities in mice lacking GDNF

1996 • 1,260 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1996 • 1,208 citations

GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

1996 • 1,170 citations

Characterization of a multicomponent receptor for GDNF

1996 • 1,086 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

Multiple promoters direct tissue-specific expression of the rat BDNF gene

1993 • 851 citations

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy

1990 • 840 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

1994 • 804 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA.

1992 • 719 citations

Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section

1992 • 712 citations

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

1990 • 700 citations

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

1992 • 693 citations

Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve.

1993 • 685 citations

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1993 • 670 citations

Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death

1992 • 668 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

1989 • 624 citations

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

1994 • 620 citations

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

1992 • 592 citations

Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry

1992 • 588 citations

Opposing Roles for Endogenous BDNF and NT-3 in Regulating Cortical Dendritic Growth

1997 • 578 citations

GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney

1998 • 550 citations

Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

1993 • 537 citations

Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons

1992 • 521 citations

Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations

1991 • 500 citations

Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis

1995 • 476 citations

The role of neurotrophins in the developing nervous system

1994 • 472 citations

Cardiotrophin-1

1995 • 432 citations

Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4

1995 • 413 citations

The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development

1993 • 402 citations

Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth

1995 • 376 citations

Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration.

1992 • 365 citations

Cloning of Complementary DNA for GAP-43, a Neuronal Growth-Related Protein

1987 • 351 citations

Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor.

1995 • 337 citations

Developmental Requirement of gp130 Signaling in Neuronal Survival and Astrocyte Differentiation

1999 • 324 citations

Essential function of LIF receptor in motor neurons

1995 • 318 citations

Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo

1992 • 309 citations

Ventral root avulsion: An experimental model of death of adult motor neurons

1994 • 293 citations

Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: Inhibition by antibodies to NGF

1991 • 284 citations

Members of several gene families influence survival of rat motoneurons in vitro and in vivo

1993 • 274 citations

Retrograde axonal transport of LIF is increased by peripheral nerve injury: Correlation with increased LIF expression in distal nerve

1994 • 268 citations

Role of neurotrophins in mouse neuronal development

1994 • 261 citations

Injury‐induced Regulation of Ciliary Neurotrophic Factor mRNA in the Adult Rat Brain

1993 • 251 citations

Dependence of postnatal motoneurones on their targets: review and hypothesis

1992 • 245 citations

NEUROTROPHINS AND THEIR RECEPTORS IN NERVE INJURY AND REPAIR

1997 • 243 citations

Differential Regulation of mRNAs for GDNF and its Receptors Ret and GDNFRα After Sciatic Nerve Lesion in the Mouse

1997 • 242 citations

Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse

1994 • 242 citations

Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury

1993 • 230 citations

Major changes in the expression of the mRNAs for cholinergic differentiation factor/leukemia inhibitory factor and its receptor after injury to adult peripheral nerves and ganglia.

1994 • 228 citations

Cyclic AMP Elevation Is Sufficient to Promote the Survival of Spinal Motor NeuronsIn Vitro

1998 • 216 citations

Motoneurons of the rat sciatic nerve

1986 • 215 citations

Motoneuron death after sciatic nerve section in newborn rats

1984 • 213 citations

Influences of neurotrophins on mammalian motoneurons in vivo

1993 • 205 citations

GDNF mRNA in Schwann cells and DRG satellite cells after chronic sciatic nerve injury

1996 • 203 citations

BDNF Prevents and Reverses Adult Rat Motor Neuron Degeneration and Induces Axonal Outgrowth

1997 • 194 citations

Brain-derived neurotrophic factor promotes axonal regeneration and long-term survival of adult rat spinal motoneurons in vivo

1997 • 186 citations

Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: Differential regulation of GAP-43, tubulins, and neurofilament-M

1999 • 181 citations

Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral root avulsion

1995 • 175 citations

Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF

1996 • 168 citations

Increased Expression of BDNF and trkB mRNA in Rat Facial Motoneurons after Axotomy

1996 • 157 citations

Quantitative Comparison of the Transient Rescue Effects of Neurotrophic Factors on Axotomized Motoneurons In Vivo

1995 • 149 citations

Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice.

1995 • 145 citations

Cytokines which signal through the LIF receptor and their actions in the nervous system

1997 • 140 citations

Developmentally Regulated Expression of HDNF/NT‐3 mRNA in Rat Spinal Cord Motoneurons and Expression of BDNF mRNA in Embryonic Dorsal Root Ganglion

1991 • 138 citations

Leukemia Inhibitory Factor Is Expressed in Astrocytes Following Cortical Brain Injury

1997 • 130 citations

gp130, a Shared Signal Transducing Receptor Component for Hematopoietic and Neuropoietic Cytokines

1996 • 126 citations

Leukaemia Inhibitory Factor Induced in the Sciatic Nerve after Axotomy is Involved in the Induction of Galanin in Sensory Neurons

1996 • 124 citations

Synergistic Effects of Schwann- and Muscle-Derived Factors on Motoneuron Survival Involve GDNF and Cardiotrophin-1 (CT-1)

1998 • 122 citations

Regulation of GDNF expression in cultured astrocytes by inflammatory stimuli

1997 • 122 citations

Neurotrophin 4/5 is a trophic factor for mammalian facial motor neurons.

1994 • 120 citations

Analysis of neuronal and glial phenotypes in brains of mice deficient in leukemia inhibitory factor

1998 • 118 citations

Evidence for the Existence of at Least Two Timing Mechanisms That Contribute to Oligodendrocyte Generationin Vitro

1996 • 114 citations

Analysis of neuronal and glial phenotypes in brains of mice deficient in leukemia inhibitory factor

1998 • 108 citations

Expression of GAP-43 mRNA in the adult mammalian spinal cord under normal conditions and after different types of lesions, with special reference to motoneurons

1992 • 100 citations

‘Dendraxons’ in regenerating motoneurons in the cat: do dendrites generate new axons after central axotomy?

1985 • 97 citations

Neurotrophic Factors: Switching neurotrophin dependence

1994 • 96 citations

Differential temporal expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFRα, LIFRβ, IL-6Rα and gp130) in injured peripheral nerves

1998 • 91 citations

Expression of MHC Class I and β2-Microglobulin in Rat Spinal Motoneurons: Regulatory Influences by IFN-Gamma and Axotomy

1998 • 89 citations

Neuroprotection of Spinal Motoneurons Following Targeted Transduction with an Adenoviral Vector Carrying the Gene for Glial Cell Line-Derived Neurotrophic Factor

1998 • 89 citations

Expression of NMDA Receptor mRNAs in Rat Motoneurons is Down‐regulated after Axotomy

1995 • 87 citations

The Signal Transducer gp130 Is Shared by lnterleukin-6 Family of Haematopoietic and Neurotrophic Cytokines

1997 • 78 citations

GDNF and its receptor component Ret in injured human nerves and dorsal root ganglia

1998 • 74 citations

Fibroblast Growth Factors Regulate Calcitonin Gene‐related Peptide mRNA Expression in Rat Motoneurons after Lesion and in Culture

1995 • 73 citations

Neuroprotective effect of various cytokines on developing spinal motoneurons following axotomy

1996 • 69 citations

Calcitonin Gene‐related Peptide (CGRP)‐like Immunoreactivity and CGRP mRNA in Rat Spinal Cord Motoneurons after Different Types of Lesions

1991 • 69 citations

Increased trkB mRNA expression by axotomized motoneurones

1994 • 67 citations

Naturally occurring and axotomy-induced motoneuron death and its prevention by neurotrophic agents: a comparison between chick and mouse

1994 • 64 citations

Regulation of spinal motoneuron survival by GDNF during development and following injury

1996 • 62 citations

Changes in the mRNA expression pattern, with special reference to calcitonin gene-related peptide, after axonal injuries in rat motoneurons depends on age and type of injury

1998 • 62 citations

Selective Upregulation of Cytokine Receptor Subchain and Their Intracellular Signalling Molecules After Peripheral Nerve Injury

1997 • 51 citations

Motoneuron differentiation, survival and synaptogenesis

1997 • 50 citations

Reduction in the number of spinal motor neurons in neurotrophin-3-deficient mice

1995 • 49 citations

Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF

1996 • 48 citations

Molecular cloning and characterization of the rat liver IL-6 signal transducing molecule, gp130

1992 • 47 citations

Role of neurotrophic factors in motoneuron development

1998 • 46 citations

Influence of growth factors on neuronal differentiation

1995 • 45 citations

A paracrine effect for neuron-derived BDNF in development of dorsal root ganglia: Stimulation of Schwann cell myelin protein expression by glial cells

1997 • 38 citations

Up-regulation of GDNFR-α and c-ret mRNA in facial motor neurons following facial nerve injury in the rat

1998 • 34 citations

Leukemia inhibitory factor, glial cell line-derived neurotrophic factor, and their receptor expressions following muscle crush injury

1999 • 28 citations

Upregulation of GFRα-1 and c-ret in primary sensory neurons and spinal motoneurons of aged rats

1999 • 25 citations

Molecular cloning and functional analysis of cDNA encoding a rat leukemia inhibitory factor: towards generation of pluripotent rat embryonic stem cells

1998 • 23 citations

Expression of GAP‐43 mRNA in Mouse Spinal Cord Following Unilateral Peripheral Nerve Damage: is There a Contralateral Effect?

1993 • 18 citations

Increased expression of the alpha subunit of the ciliary neurotrophic factor (CNTF) receptor by rat facial motoneurons after neonatal axotomy and CNTF treatment

1996 • 13 citations

Molecular cloning of rat leukemia inhibitory factor receptor α-chain gene and its expression during pregnancy

1997 • 12 citations

Rescue of Motoneurons from Axotomy-Induced Cell Death by Polymer Encapsulated Cells Genetically Engineered to Release CNTF

1996 • 12 citations