Antigen and superantigen presentation in the human CNS

T‐lymphocyte entry into the central nervous system

1991 • 1,168 citations

Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?

1999 • 1,011 citations

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

1999 • 881 citations

Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis

1996 • 741 citations

Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

1991 • 675 citations

OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS

1933 • 629 citations

Immune Invasion of the Central Nervous System Parenchyma and Experimental Allergic Encephalomyelitis, But Not Leukocyte Extravasation from Blood, Are Prevented in Macrophage-Depleted Mice

1998 • 344 citations

Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide

1992 • 302 citations

Immunopathology of multiple sclerosis: Report on an international meeting held at the Institute of Neurology of the University of Vienna

1998 • 240 citations

Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia

1996 • 217 citations

The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis

1995 • 213 citations

The functional significance of epitope spreading and its regulation by co‐stimulatory molecules

1998 • 162 citations

Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) by Human Brain Microvessel Endothelial Cells in Primary Culture

1995 • 131 citations

Blockade of CD28 During In Vitro Activation of Encephalitogenic T Cells or After Disease Onset Ameliorates Experimental Autoimmune Encephalomyelitis

1999 • 123 citations

Phenotypic Differences between Human Monocytes/Macrophages and Microglial Cells StudiedIn SituandIn Vitro

1994 • 118 citations

The induction of ICAM-1 in human cerebromicrovascular endothelial cells (HCEC) by ischemia-like conditions promotes enhanced neutrophil/HCEC adhesion

1997 • 100 citations

Direct demonstration of the infiltration of murine central nervous system by Pgp-1/CD44high CD45RBlow CD4+ T cells that induce experimental allergic encephalomyelitis

1992 • 91 citations

CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells.

1999 • 86 citations

Differential proliferative response of human and mouse astrocytes to gamma‐interferon

1992 • 84 citations

HLA class II molecules (HLA-DR, -DP, -DQ) on cells in the human CNS studied in situ and in vitro.

1994 • 83 citations

Regulation of CD14 expression on human adult central nervous system-derived microglia

1996 • 82 citations

Induction of primary T cell responses by human glial cells

1993 • 77 citations

Expression of Tumor Necrosis Factor α (TNFα) and Interleukin 6 (IL-6) mRNA in Adult Human Astrocytes

1996 • 75 citations

CD40 engagement stimulates IL-12 p70 production by human microglial cells: basis for Th1 polarization in the CNS

2000 • 73 citations

CD40-CD154 Interaction and IFN-γ Are Required for IL-12 But Not Prostaglandin E2 Secretion by Microglia During Antigen Presentation to Th1 Cells

1999 • 67 citations

Antigen presentation by human fetal astrocytes with the cooperative effect of microglia or the microglial-derived cytokine IL-1

1995 • 62 citations

B7 Expression and Antigen Presentation by Human Brain Endothelial Cells: Requirement for Proinflammatory Cytokines

2000 • 60 citations

Dissociation of antigen-presenting capacity of astrocytes for peptide-antigens versus superantigens.

1993 • 31 citations

Immune and non-immune actions of interferon-β-1b on primary human neural cells

1995 • 16 citations

Induction of B7.1 and B7.2 co-stimulatory molecule on the surface of human brain endothelial cells

1998 • 7 citations

Superantigen presenting capacity of human astrocytes

2000 • 7 citations

Bradykinin B1 receptor regulates the migration of lymphocytes in multiple sclerosis

1998 • 6 citations

Expression of the co-stimulatory molecules B7 and LFA-3 by cerebral endothelium is important for effective T-cell proliferation

1998 • 3 citations