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1996 • 1,892 citations

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1992 • 1,279 citations

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1988 • 605 citations

Two steps in the assembly of complexes at yeast replication origins in vivo

1994 • 566 citations

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1996 • 512 citations

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1997 • 503 citations

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1997 • 496 citations

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1995 • 469 citations

The fission yeast cdc18+ gene product couples S phase to START and mitosis

1993 • 446 citations

Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a ‘reductional’ anaphase in the budding yeast Saccharomyces cerevisiae.

1995 • 402 citations

INITIATION OF DNA REPLICATION IN EUKARYOTIC CELLS

1997 • 399 citations

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1994 • 393 citations

The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free Extracts

1996 • 387 citations

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1992 • 380 citations

S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state

1995 • 366 citations

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

1996 • 362 citations

Purification of an MCM-containing complex as a component of the DNA replication licensing system

1995 • 361 citations

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1997 • 359 citations

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

1995 • 357 citations

Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene

1994 • 356 citations

Improved cervical smear assessment using antibodies against proteins that regulate DNA replication

1998 • 319 citations

Cyclin/Cdk-Dependent Initiation of DNA Replication in a Human Cell-Free System

1997 • 311 citations

Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast.

1996 • 293 citations

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1997 • 287 citations

Identification of the yeast MCM3-related protein as a component of xenopus DNA replication licensing factor

1995 • 280 citations

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1998 • 275 citations

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

1998 • 261 citations

p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast

1995 • 259 citations

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1996 • 255 citations

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1996 • 251 citations

Conserved Initiator Proteins in Eukaryotes

1995 • 246 citations

BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication.

1995 • 234 citations

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1995 • 220 citations

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1996 • 213 citations

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1996 • 207 citations

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1993 • 198 citations

p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase

1995 • 190 citations

DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period.

1994 • 173 citations

A Role for Cdk2 Kinase in Negatively Regulating DNA Replication during S Phase of the Cell Cycle

1997 • 153 citations

Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication

1996 • 151 citations

A human protein related to yeast Cdc6p

1997 • 147 citations

Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division.

1992 • 143 citations

The nuclear membrane prevents replication of human G2 nuclei but not G1 nuclei in Xenopus egg extract

1992 • 140 citations

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1995 • 140 citations

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1996 • 129 citations

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1996 • 126 citations

Putting It All Together: Building a Prereplicative Complex

1997 • 126 citations

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1998 • 122 citations

The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts

1995 • 119 citations

Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication.

1996 • 112 citations

The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation.

1994 • 96 citations

Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe.

1996 • 96 citations

XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication.

1996 • 84 citations

Reversible effects of nuclear membrane permeabilization on DNA replication: evidence for a positive licensing factor

1993 • 83 citations

Determination of initiation of DNA replication before and after nuclear formation in Xenopus egg cell free extracts.

1993 • 78 citations

Cdc6p establishes and maintains a state of replication competence during G1 phase

1997 • 59 citations

Mechanisms restricting DNA replication to once per cell cycle: MCMS, pre-replicative complexes and kinases

1996 • 58 citations

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1988 • 40 citations

Initiation of DNA replication in nuclei from quiescent cells requires permeabilization of the nuclear membrane.

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1996 • 34 citations

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1996 • 31 citations

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1995 • 30 citations

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1996 • 28 citations

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