Ectopic induction of Clb2 in early G ₁ phase is sufficient to block prereplicative complex formation in Saccharomyces cerevisiae

Current protocols in molecular biology

1988 • 4,543 citations

[19] Targeting, disruption, replacement, and allele rescue: Integrative DNA transformation in yeast

1991 • 1,369 citations

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

1992 • 1,279 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

Components and Dynamics of DNA Replication Complexes in S. cerevisiae: Redistribution of MCM Proteins and Cdc45p during S Phase

1997 • 743 citations

[20] In vitro mutagenesis and plasmid shuffling: From cloned gene to mutant yeast

1991 • 584 citations

Two steps in the assembly of complexes at yeast replication origins in vivo

1994 • 566 citations

CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae.

1993 • 521 citations

Loading of an Mcm Protein onto DNA Replication Origins Is Regulated by Cdc6p and CDKs

1997 • 503 citations

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle

1994 • 478 citations

The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae

1991 • 463 citations

The roles of Drosophila cyclins A and B in mitotic control

1990 • 429 citations

Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a ‘reductional’ anaphase in the budding yeast Saccharomyces cerevisiae.

1995 • 402 citations

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1994 • 393 citations

CLB5: a novel B cyclin from budding yeast with a role in S phase.

1992 • 391 citations

Protein-DNA interactions at a yeast replication origin

1992 • 380 citations

S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state

1995 • 366 citations

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

1996 • 362 citations

Viewpoint: Putting the Cell Cycle in Order

1996 • 357 citations

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

1995 • 357 citations

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

1991 • 340 citations

Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae.

1992 • 310 citations

Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast.

1996 • 293 citations

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

1997 • 287 citations

Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.

1992 • 281 citations

p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast

1995 • 259 citations

Cell Cycle Regulation of the Yeast Cdc7 Protein Kinase by Association With the Dbf4 Protein†

1993 • 250 citations

Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells.

1996 • 240 citations

Linkage of Replication to Start by the Cdk Inhibitor Sic1

1996 • 230 citations

Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis.

1995 • 220 citations

Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.

1995 • 179 citations

Regulation of the replication initiator protein p65^cdc18 by CDK phosphorylation

1997 • 165 citations

A Role for Cdk2 Kinase in Negatively Regulating DNA Replication during S Phase of the Cell Cycle

1997 • 153 citations

The role of MCM proteins in the cell cycle control of genome duplication

1996 • 139 citations

cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe.

1996 • 129 citations

Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases.

1996 • 121 citations

CDC 45 is required in conjunction with CDC 7/ DBF 4 to trigger the initiation of DNA replication

1997 • 92 citations

Life and Cancer Without Telomerase

1997 • 85 citations

Transcriptional regulation of the MET3 gene of Saccharomyces cerevisiae

1985 • 85 citations

Mcm2 and Mcm3 are constitutive nuclear proteins that exhibit distinct isoforms and bind chromatin during specific cell cycle stages of Saccharomyces cerevisiae.

1997 • 70 citations

Cdc6p establishes and maintains a state of replication competence during G1 phase

1997 • 59 citations

Interaction of the S phase regulator Cdc18 with cyclin-dependent kinase in fission yeast

1997 • 45 citations