Radiotracers for positron emission tomography imaging

A review of central 5-HT receptors and their function

1999 • 3,121 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-¹¹C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

1990 • 1,412 citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

1998 • 1,304 citations

Imaging proliferation in vivo with [F-18]FLT and positron emission tomography

1998 • 1,213 citations

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

1998 • 1,204 citations

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method

1997 • 1,147 citations

Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease

2001 • 950 citations

Imaging Synaptic Neurotransmission within VivoBinding Competition Techniques: A Critical Review

2000 • 938 citations

Dopamine Transporter Occupancies in the Human Brain Induced by Therapeutic Doses of Oral Methylphenidate

1998 • 878 citations

Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects

1997 • 843 citations

Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain

2001 • 832 citations

ATP and Brain Function

1989 • 812 citations

Effects of Age on Dopamine and Serotonin Receptors Measured by Positron Tomography in the Living Human Brain

1984 • 701 citations

Central D2-Dopamine Receptor Occupancy in Schizophrenic Patients Treated With Antipsychotic Drugs

1988 • 692 citations

Inhibition of monoamine oxidase B in the brains of smokers

1996 • 666 citations

Relationship between subjective effects of cocaine and dopamine transporter occupancy

1997 • 653 citations

Dopamine visualized in the basal ganglia of living man

1983 • 643 citations

The peripheral benzodiazepine binding site in the brain in multiple sclerosis

2000 • 643 citations

Radiolabeled amino acids: basic aspects and clinical applications in oncology.

2001 • 553 citations

Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadoran poison frog

1992 • 553 citations

Neurobiology of Mental Illness

2011 • 532 citations

Enigma of the peripheral benzodiazepine receptor.

1999 • 499 citations

Synthesis and radiopharmacology of O-(2-[18F]fluoroethyl)-L-tyrosine for tumor imaging.

1999 • 454 citations

Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain

2001 • 446 citations

Brain monoamine oxidase A inhibition in cigarette smokers

1996 • 427 citations

Binding Characteristics of Radiofluorinated 6-Dialkylamino-2-Naphthylethylidene Derivatives as Positron Emission Tomography Imaging Probes for β-Amyloid Plaques in Alzheimer's Disease

2001 • 413 citations

Positron emission tomography and autoradiography: Principles and applications for the brain and heart

1986 • 396 citations

Mapping Human Brain Monoamine Oxidase A and B with ¹¹ C-Labeled Suicide Inactivators and PET

1987 • 388 citations

Imaging endogenous dopamine competition with [¹¹C]raclopride in the human brain

1994 • 378 citations

Cigarette smoking and protection from Parkinson's disease

1995 • 372 citations

IN-VIVO DEMONSTRATION OF REDUCED BENZODIAZEPINE RECEPTOR BINDING IN HUMAN EPILEPTIC FOCI

1988 • 361 citations

Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer.

2001 • 356 citations

Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies.

1999 • 353 citations

Compartmental Analysis of [¹¹C]Flumazenil Kinetics for the Estimation of Ligand Transport Rate and Receptor Distribution Using Positron Emission Tomography

1991 • 344 citations

Neurobiology of Mental Illness.

2000 • 344 citations

Gender and Age Influences on Human Brain Mu-Opioid Receptor Binding Measured by PET

1999 • 332 citations

Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging

1996 • 312 citations

Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography.

1985 • 304 citations

An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.

1997 • 286 citations

Striatal binding of the PET ligand ¹¹C‐raclopride is altered by drugs that modify synaptic dopamine levels

1993 • 285 citations

Imaging the serotonin transporter with positron emission tomography: initial human studies with [11C]DAPP and [11C]DASB

2000 • 273 citations

Imaging Opiate Receptors in the Human Brain by Positron Tomography

1985 • 256 citations

USE AND ABUSE OF ELECTROENCEPHALOGRAPHY.

1964 • 252 citations

PET evaluation of the dopamine system of the human brain.

1996 • 249 citations

Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression.

2001 • 228 citations

Novel 3-Pyridyl Ethers with Subnanomolar Affinity for Central Neuronal Nicotinic Acetylcholine Receptors

1996 • 227 citations

Carbon-11-FLB 457: a radioligand for extrastriatal D2 dopamine receptors.

1995 • 224 citations

Differential Regulation of Molecular Subtypes of Muscarinic Receptors in Alzheimer's Disease

1995 • 221 citations

Radiosynthesis of 3′-deoxy-3′-[18F]fluorothymidine: [18F]FLT for imaging of cellular proliferation in vivo

2000 • 217 citations

Carbon-11-thymidine and FDG to measure therapy response.

1998 • 215 citations

Assays for noninvasive imaging of reporter gene expression

1999 • 214 citations

Dopamine D3 receptor as a therapeutic target for antipsychotic and antiparkinsonian drugs

2001 • 213 citations

Decreased dopamine transporters with age in healthy human subjects

1994 • 205 citations

Synthesis and evaluation of [18F]1-amino-3-fluorocyclobutane-1-carboxylic acid to image brain tumors.

1999 • 190 citations

Re-evaluation of amino acid PET studies: can the protein synthesis rates in brain and tumor tissues be measured in vivo?

1993 • 186 citations

Positron emission tomography imaging of serotonin transporters in the human brain using [¹¹C](+)McN5652

1995 • 175 citations

A New Method to Measure Brain Serotonin Synthesis in vivo. I. Theory and Basic Data for a Biological Model

1990 • 175 citations

In vivo visualization of activated glia by[11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion

2001 • 171 citations

Epibatidine is a nicotinic analgesic

1993 • 168 citations

Working against Time: Rapid Radiotracer Synthesis and Imaging the Human Brain

1997 • 168 citations

Cerebral Metabolism of 6–[¹⁸F]Fluoro‐l‐3,4‐Dihydroxyphenylalanine in the Primate

1987 • 164 citations

PET Imaging of human gliomas with ligands for the peripheral benzodiazepine binding site

1989 • 164 citations

Increased amino acid transport into brain tumors measured by PET of L-(2-18F)fluorotyrosine.

1991 • 160 citations

Selective reduction of radiotracer trapping by deuterium substitution: comparison of carbon-11-L-deprenyl and carbon-11-deprenyl-D2 for MAO B mapping.

1995 • 155 citations

Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine

1992 • 155 citations

Radiosynthesis of an opiate receptor binding radiotracer: [11C]carfentanil

1985 • 149 citations

Measurement of Striatal and Extrastriatal Dopamine D₁ Receptor Binding Potential With [¹¹C]NNC 112 in Humans: Validation and Reproducibility

2000 • 148 citations

Detection of DNA Synthesis in Intact Organisms with Positron-Emitting [ Methyl - ¹¹ C]Thymidine

1972 • 139 citations

Utilization of labeled thymidine in DNA synthesis: studies for PET.

1990 • 138 citations

Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites—current status

1993 • 136 citations

PET imaging of central 5-HT2A receptors with carbon-11-MDL 100,907.

1998 • 130 citations

Synthesis and Nicotinic Acetylcholine Receptor in Vivo Binding Properties of 2-Fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: A New Positron Emission Tomography Ligand for Nicotinic Receptors

1999 • 126 citations

2-[C-11]thymidine imaging of malignant brain tumors.

1999 • 126 citations

DYNAMICS OF HEMOPOIETIC PROLIFERATION IN MAN AND MICE STUDIED BY H³‐THYMIDINE INCORPORATION INTO DNA*

1959 • 125 citations

Quantitative analyses of carbonyl-carbon-11-WAY-100635 binding to central 5-hydroxytryptamine-1A receptors in man.

1998 • 124 citations

Cerebral metabolism of L-[2-18F]fluorotyrosine, a new PET tracer of protein synthesis.

1989 • 122 citations

Synthesis of 2′-fluoro-5-[11C]-methyl-1-β-d-arabinofuranosyluracil ([11C]-FMAU): A potential nucleoside analog for in vivo study of cellular proliferation with PET

1995 • 122 citations

Carbon-11-NNC 112: a radioligand for PET examination of striatal and neocortical D1-dopamine receptors.

1998 • 119 citations

Design and evaluation of radioactive acetylcholine analogs for mapping brain acetylcholinesterase (AchE) in vivo

1994 • 119 citations

Human nicotinic receptors—Their role in aging and dementia

1994 • 117 citations

PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756

1999 • 116 citations

A Method for the In Vivo Investigation of the Serotonergic 5‐HT₂ Receptors in the Human Cerebral Cortex Using Positron Emission Tomography and ¹⁸F‐Labeled Setoperone

1990 • 110 citations

Opioid receptor imaging with positron emission tomography and [(18)F]cyclofoxy in long-term, methadone-treated former heroin addicts.

2000 • 110 citations

Measurement of local cerebral protein synthesis in vivo: influence of recycling of amino acids derived from protein degradation.

1988 • 110 citations

[11C](+)McN5652 as a radiotracer for imaging serotonin uptake sites with pet

1993 • 108 citations

Development of labeled thymidine analogs for imaging tumor proliferation

1996 • 107 citations

In vivo studies of acetylcholinesterase activity using a labeled substrate,N-[11C]methylpiperdin-4-yl propionate ([11C]PMP)

1996 • 105 citations

Effects of endogenous dopamine on measures of [¹⁸F]N‐methylspiroperidol binding in the basal ganglia: Comparison of simulations and experimental results from PET studies in baboons

1991 • 105 citations

IBOX(2-(4′-dimethylaminophenyl)-6-iodobenzoxazole): a ligand for imaging amyloid plaques in the brain

2001 • 103 citations

p-[18F]-MPPF: A potential radioligand for PET studies of 5-HT1A receptors in humans

1997 • 102 citations

In vivo Muscarinic Cholingeric Receptor Imaging in Human Brain with [¹¹C]Scopolamine and Positron Emission Tomography

1992 • 101 citations

Muscarinic Cholinergic Receptor Measurements with [¹⁸F]FP-TZTP: Control and Competition Studies

1998 • 101 citations

(−)-N-[11C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D2 receptors

2000 • 101 citations

[11C]WAY 100635: A radioligand for imaging 5-HT1A receptors with positron emission tomography

1994 • 98 citations

Isolation and Characterization of a Monoamine Oxidase Inhibitor from Tobacco Leaves

1999 • 98 citations

Biodistribution studies on L-3-[fluorine-18]fluoro-alpha-methyl tyrosine: a potential tumor-detecting agent.

1998 • 96 citations

18F alpha-methyl tyrosine PET studies in patients with brain tumors.

1999 • 92 citations

Development of ligands for in vivo imaging of cerebral nicotinic receptors

2000 • 90 citations

6-[18F]fluoro-A-85380: an in vivo tracer for the nicotinic acetylcholine receptor

2000 • 90 citations

Estimation of Local Cerebral Protein Synthesis Rates with L-[1-¹¹C]Leucine and PET: Methods, Model, and Results in Animals and Humans

1989 • 90 citations

Characterizing Tumors Using Metabolic Imaging: PET Imaging of Cellular Proliferation and Steroid Receptors

2000 • 89 citations

[18F]Fluoro-l-dopa for the in vivo study of intracerebral dopamine

1986 • 89 citations

Monoamine re-uptake sites in the human brain evaluatedin vivoby means of¹¹C-nomifensine and positron emission tomography: the effects of age and Parkinson's disease

1988 • 88 citations

Chapter 30 Attempts to visualize nicotinic receptors in the brain of monkey and man by positron emission tomography

1989 • 88 citations

Amino acids for the measurement of protein synthesis in vivo by PET

1992 • 87 citations

Enzymatic Synthesis of Carboxy-11C-Labelled L-Tyrosine, L-DOPA, L-Tryptophan and 5-Hydroxy-L-tryptophan.

1990 • 85 citations

Compounds Labelled with Short-Lived beta+-Emitting Radionuclides and Some Applications in Life Sciences. The Importance of Time as a Parameter.

1999 • 85 citations

Synthesis of isomers of 18F-labelled amino acid radiopharmaceutical

1997 • 82 citations

Kinetic analysis of 2-[11C]thymidine PET imaging studies: validation studies.

1999 • 82 citations

Multicompartmental study of fluorine-18 altanserin binding to brain 5HT2 receptors in humans using positron emission tomography

1994 • 81 citations

Evaluation of age-related changes in serotonin 5-HT2 and dopamine D2 receptor availability in healthy human subjects

1995 • 77 citations

Quantitation of striatal and extrastriatal D-2 dopamine receptors using PET imaging of [18F]fallypride in nonhuman primates

2000 • 77 citations

Assessment of muscarinic receptor concentrations in aging and Alzheimer disease with [11C]NMPB and PET

2001 • 76 citations

The Suitability of [¹¹C]-α-Methyl-L-tryptophan as a Tracer for Serotonin Synthesis: Studies With Dual Administration of [¹¹C] and [¹⁴C] Labeled Tracer

2000 • 76 citations

Evaluation of Serotonergic Transporters using PET and [¹¹C](+)McN-5652: Assessment of Methods

2000 • 76 citations

Imaging of ? opioid receptors in human brain by N1?- ([11C]methyl)naltrindole and PET

1996 • 76 citations

[11]Cocaine: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy

2001 • 75 citations

Hidden persuasion

1996 • 74 citations

Assessment of cardiac sympathetic nerve integrity with positron emission tomography

2001 • 73 citations

Synthesis of 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine, a highly potent radioligand for in vivo imaging central nicotinic acetylcholine receptors

1998 • 72 citations

Mapping nicotinic acetylcholine receptors with PET

1996 • 71 citations

General Method to Label Antisense Oligonucleotides with Radioactive Halogens for Pharmacological and Imaging Studies

2000 • 71 citations

Imaging brain cholinergic activity with positron emission tomography: its role in the evaluation of cholinergic treatments in Alzheimer’s dementia

2001 • 70 citations

Platelet monoamine oxidase, smoking cessation, and tobacco withdrawal symptoms

2001 • 69 citations

Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: (+/−)-exo-2-(2-[18F]fluoro-5-pyridyl)-7-azabicyclo[2.2.1]heptane

1996 • 68 citations

Imaging central nicotinic acetylcholine receptors in baboons with [18F]fluoro-A-85380.

1999 • 68 citations

A PET study of D 1 -like dopamine receptor ligand binding

1999 • 68 citations

Monoamine oxidases: old friends hold many surprises

1995 • 65 citations

Ligands and tracers for PET studies of the 5-HT system—current status

1992 • 63 citations

Evaluation of fluorinated m-tyrosine analogs as PET imaging agents of dopamine nerve terminals: comparison with 6-fluoroDOPA.

1997 • 63 citations

In Vivo Imaging of Human Cerebral Acetylcholinesterase

1996 • 63 citations

Fluoro-norchloroepibatidine: Preclinical assessment of acute toxicity

1997 • 61 citations

PET quantification of specific binding of carbon-11-nicotine in human brain.

1998 • 60 citations

(S)- and (R)-[11C]nicotine and the metabolite ()-[11C]cotinine. preparation, metabolite studies and in vivo distribution in the human brain using PET

1992 • 60 citations

Effect of amphetamine on extrastriatal D2 dopamine receptor binding in the primate brain: A PET study

2000 • 59 citations

Synthesis of some 11C-labelled MAO-A inhibitors and their in vivo uptake kinetics in rhesus monkey brain

1997 • 58 citations

Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: 2-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[18F]A-85380)

1998 • 58 citations

Tobacco Smoking and Nicotine Neuropsychopharmacology: Some Future Research Directions

1998 • 57 citations

Short-term thymidine uptake in normal and neoplastic tissues: studies for PET.

1984 • 56 citations

PET radiopharmaceuticals: state-of-the-art and future prospects

1998 • 56 citations

The preparation of carbon-11 labelled diprenorphine: a new radioligand for the study of the opiate receptor system in vivo

1985 • 55 citations

Synthesis and evaluation of 6-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine as a PET tracer for nicotinic acetylcholine receptors

2000 • 53 citations

Tissue Distribution, Autoradiography, and Metabolism of 4‐(2′‐Methoxyphenyl)‐1‐[2′ ‐[N‐2″‐Pyridinyl)‐p‐[¹⁸F]Fluorobenzamido]ethyl]piperazine (p‐[¹⁸F]MPPF), a New Serotonin 5‐HT_1A Antagonist for Positron Emission Tomography

2000 • 49 citations

3-(2′-[18F]fluoroethyl)spiperone, a potent dopamine antagonist: Synthesis, structural analysis and in-vivo utilization in humans

1990 • 49 citations

Preparation of 18F-Labeled Muscarinic Agonist with M2 Selectivity

1995 • 48 citations

Comparative studies of epibatidine derivatives [18F]NFEP and [18F]N-Methyl-NFEP: kinetics, nicotine effect, and toxicity

1999 • 48 citations

In vivo radiotracers for vesicular neurotransmitter transporters

1997 • 48 citations

PET quantification of 5-HT2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin.

2000 • 47 citations

Dopamine Receptor‐Mediated Regulation of Striatal Cholinergic Activity

2000 • 46 citations

N-(3-[18F]fluoropropyl)-spiperone: The preferred 18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor

1988 • 46 citations

Synthesis, in vivo biodistribution and dosimetry of [11C]N-Methylpiperidyl benzilate ([11C]NMPB), a muscarinic acetylcholine receptor antagonist

1995 • 46 citations

In Vivo Quantification of Cerebral Muscarinic Receptors in Normal Human Aging Using Positron Emission Tomography and [¹¹C]Tropanyl Benzilate

1996 • 45 citations

Synthesis of a radiotracer for studying serotonin uptake sites with positron emission tomography: [¹¹C]McN‐5652‐Z

1992 • 45 citations

Brain net unidirectional uptake of alpha-[14c]methyl-L-tryptophan (alpha-MTrp) and its correlation with regional serotonin synthesis, tryptophan incorporation into proteins, and permeability surface area products of tryptophan and alpha-MTrp.

2000 • 44 citations

Non selective transport of [11C-methyl]-L-and D-methionine into a malignant glioma

1987 • 44 citations

Comparison of high specific activity (-) and (+)-6-[18F]fluoronorepinephrine and 6-[18F]fluorodopamine in baboons: heart uptake, metabolism and the effect of desipramine.

1993 • 43 citations

[18F]p-MPPF: A Radiolabeled Antagonist for the Study of 5-HT1A Receptors with PET

2000 • 43 citations

N 3 fluorine 18 fluoropropylspiperone the preferred fluorine 18 labeled spiperone analog for positron emission tomographic studies of the dopamine receptor

1988 • 41 citations

Breast imaging technology: Recent advances in imaging endogenous or transferred gene expression utilizing radionuclide technologies in living subjects: applications to breast cancer

2000 • 41 citations

Evaluation of 5‐[¹⁸F]Fluoropropylepidepride as a potential pet radioligand for imaging dopamine D2 receptors

1993 • 41 citations

Synthesis and regional mouse brain distribution of [11C]Nisoxetine, a norepinephrine uptake inhibitor

1989 • 40 citations

Characterization of R-[11C]rolipram for PET imaging of phosphodiesterase-4: in vivo binding, metabolism, and dosimetry studies in rats

2001 • 40 citations

Evaluation of novel PET ligands (+)N-[11C]methyl-3-piperidyl benzilate ([11C](+)3-MPB) and its stereoisomer [11C](-)3-MPB for muscarinic cholinergic receptors in the conscious monkey brain: A PET study in comparison with [11C]4-MPB

2000 • 39 citations

Opioid receptor imaging and displacement studies with [6-O-[11C]methyl]buprenorphine in baboon brain

1996 • 36 citations

CNS Neurotransmitters and Neuromodulators: Acetylcholine

1994 • 36 citations

Striatal D2/acetylcholine interactions

1993 • 34 citations

Radioligands for PET studies of central 5-HT receptors and re-uptake sites — Current status

1995 • 34 citations

Cellular sources of thymidine nucleotides: studies for PET.

1987 • 34 citations

Amino Acid Distribution and Metabolism in Pituitary Adenomas Using Positron Emission Tomography with D-[11C]Methionine and L-[11C]Methionine

1987 • 33 citations

Cerebral muscarinic acetylcholinergic receptor measurement in Alzheimer’s disease patients on11C-N-methyl-4-piperidyl benzilate — Comparison with cerebral blood flow and cerebral glucose metabolism—

1998 • 33 citations

Imaging of cAMP-specific phosphodiesterase-IV: Comparison of [11C]Rolipram and [11C]Ro 20-1724 in rats

1999 • 31 citations

Comparison of two fluorine-18 labeled benzamide derivatives that bind reversibly to dopamine D2 receptors: In vitro binding studies and positron emission tomography

1996 • 30 citations

In vivo positron emission tomography studies on the novel nicotinic receptor agonist [11C]MPA compared with [11C]ABT-418 and (S)(−)[11C]nicotine in Rhesus monkeys

1999 • 30 citations

Synthesis of radiolabeled inhibitors of presynaptic monoamine uptake systems; [¹⁸F]GBR 13119 (DA),[¹¹C]nisoxetine (NE), and [¹¹C]fluoxetine (5‐HT)

1989 • 30 citations

[11C]-methyl 4-[(3,4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)methyl]-1-piperazinecarboxylate ([11C]GR89696): synthesis and in vivo binding to kappa opiate receptors

1999 • 30 citations

Synthesis and in vivo studies of a specific monoamine oxidase B inhibitor: 5-[4-(benzyloxy)phenyl]-3-(2-cyanoethyl)-1,3,4-oxadiazol-[11C]-2(3H)-one

1996 • 29 citations

PET imaging of the opioid receptor: the early years

2001 • 27 citations

Biochemical and Autoradiographic Study of Cerebral Protein Synthesis with [¹⁸F]‐ and [¹⁴C]Fluorophenylalanine

1988 • 27 citations

Preparation of [11C]buprenorphine—A potential radioligand for the study of the opiate receptor system in vivo

1987 • 27 citations

Radiosynthesis of [18F]3-acetylcyclofoxy: a high affinity opiate antagonist

1985 • 27 citations

New insights into the pathophysiology of Parkinson's disease: the challenge of positron emission tomography

1988 • 27 citations

Automated production of several positron-emitting radiopharmaceuticals using a single laboratory robot

1988 • 27 citations

Electronic Generators for the Production of Positron-Emitter Labeled Radiopharmaceuticals Where Would PET Be Without Them?

1999 • 26 citations

Carbon‐11 labelling of an inhibitor of acetylcholinesterase: [¹¹C]physostigmine

1993 • 26 citations

Occupancy of brain nicotinic acetylcholine receptors by nicotine doses equivalent to those obtained when smoking a cigarette

2000 • 25 citations

18F-5-fluorouridine, A New Probe For Measuring The Proliferation Of Tissue in vivo

1982 • 25 citations

Quantitative evaluation of neutral amino acid transport in cerebral gliomas using positron emission tomography and fluorine-18 fluorophenylalanine

1996 • 24 citations

Synthesis and in vivo distribution in the rat of several fluorine-18 labeled N-fluoroalkylaporphines

1993 • 23 citations

Carbon-11 pb-12: an attempt to visualize the dopamine d4 receptor in the primate brain with positron emission tomography

2000 • 23 citations

Facile synthesis of [11C]buprenorphine for positron emission tomographic studies of opioid receptors

1990 • 22 citations

Reproducibility of repeated measures of cholinergic terminal density using.

2000 • 21 citations

Report of an International Atomic Energy Agency's Advisory Group Meeting on “quality control of cyclotron-produced radiopharmaceuticals”

1990 • 21 citations

Mapping Catechol-O-Methyltransferase in vivo: Initial studies with [18F]RO41-0960

1995 • 21 citations

Synthesis and initialin vitro characterization of 6-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine, a high-affinity radioligand for central nicotinic acetylcholine receptors

2000 • 19 citations

Carbon-11-forskolin: a ligand for visualization of the adenylate cyclase-related second messenger system.

1993 • 17 citations

A comparison of the brain uptake of N-(cyclopropyl[11C]methyl)norbuprenorphine ([11C]buprenorphine) and N-(cyclopropyl[11C]methyl)nordiprenorphme ([11C]diprenorphine) in baboon using PET

1991 • 17 citations

Synthesis of a radiotracer for studying serotonin uptake sites: Carbon‐11 labeled N‐methylparoxetine

1989 • 16 citations

Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1′-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors

1999 • 15 citations

Kinetic Evaluation of Positron-Emitting Muscarinic Receptor Ligands Employing Direct Intracarotid Injection

1996 • 14 citations

Radiolabeled muscarinic radioligands for in vivo studies

2001 • 13 citations

Synthesis and autoradiographic localization of the dopamine D-1 agonists [11C]SKF 75670 and [11C]SKF 82957 as potential PET radioligands

1996 • 13 citations

Synthesis and evaluation of high affinity, aryl-substituted [18F]fluoropropylbenzamides for dopamine D-2 receptor studies

1992 • 10 citations

Rapid incorporation of carbon-11-labeled diacylglycerol as a probe of signal transduction in glioma.

1995 • 10 citations

ChemInform Abstract: Novel 3‐Pyridyl Ethers with Subnanomolar Affinity for Central Neuronal Nicotinic Acetylcholine Receptors (nAChR′s).

1996 • 8 citations

PET studies of peripheral catechol-O-methyltransferase in non-human primates using [ 18 F]Ro41-0960

1998 • 5 citations

[18F]labeled 1,2-diacylglycerols: A new tracer for the imaging of second messenger system

1994 • 3 citations

Knowledge-Based Automated Radiopharmaceutical Manufacturing for Positron Emission Tomography

1991 • 2 citations

Deleted Work

1955 • 0 citations