Assessment of cardiac sympathetic nerve integrity with positron emission tomography

Cardiac Electrophysiology: From Cell to Bedside

1991 • 2,234 citations

Advanced organic chemistry

1993 • 1,935 citations

Permeability of small nonelectrolytes through lipid bilayer membranes

1986 • 482 citations

How to assess sympathetic activity in humans

1999 • 445 citations

Autonomic nervous system and sudden cardiac death

1996 • 432 citations

Heart rate spectral analysis, cardiac norepinephrine spillover, and muscle sympathetic nerve activity during human sympathetic nervous activation and failure.

1994 • 407 citations

Myocardial imaging with a radioiodinated norepinephrine storage analog.

1981 • 378 citations

Cardiac Sympathetic Denervation in Parkinson Disease

2000 • 349 citations

A simple synthesis of [11C]methyl triflate

1992 • 339 citations

Iodine-123 meta-iodobenzylguanidine scintigraphy: A noninvasive method to demonstrate myocardial adrenergic nervous system disintegrity in patients with idiopathic dilated cardiomyopathy

1988 • 333 citations

Abnormal I-123 metaiodobenzylguanidine myocardial washout and distribution may reflect myocardial adrenergic derangement in patients with congestive cardiomyopathy.

1988 • 332 citations

Sympathetic Cardioneuropathy in Dysautonomias

1997 • 316 citations

Metaiodobenzylguanidine to map scintigraphically the adrenergic nervous system in man.

1987 • 280 citations

Metaiodobenzylguanidine as an index of the adrenergic nervous system integrity and function.

1987 • 276 citations

THE INHIBITION OF NORADRENALINE UPTAKE BY SYMPATHOMIMETIC AMINES IN THE RAT ISOLATED HEART

1965 • 266 citations

The uptake of catechol amines at high perfusion concentrations in the rat isolated heart: a novel catechol amine uptake process

1997 • 249 citations

Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography.

1990 • 240 citations

Prognostic value of MIBG imaging in idiopathic dilated cardiomyopathy.

1999 • 239 citations

Atrial Fibrillation Produced by Prolonged Rapid Atrial Pacing Is Associated With Heterogeneous Changes in Atrial Sympathetic Innervation

2000 • 233 citations

Effects of Cardiac Sympathetic Innervation on Coronary Blood Flow

1997 • 228 citations

Cardiac Sympathetic Dysinnervation in Diabetes

1998 • 220 citations

Evidence for regional catecholamine uptake and storage sites in the transplanted human heart by positron emission tomography.

1991 • 218 citations

Scintigraphic assessment of MIBG uptake in globally denervated human and canine hearts--implications for clinical studies.

1992 • 198 citations

Cardiac sympathetic denervation from the early stage of Parkinson's disease: clinical and experimental studies with radiolabeled MIBG.

2000 • 195 citations

Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging.

1990 • 192 citations

Myocardial ischaemia and the cardiac nervous system

1999 • 189 citations

Dissociation constants and lipophilicity of catecholamines and related compounds

1979 • 174 citations

Autonomic Neuroeffector Mechanisms

1992 • 162 citations

Iodine-131 metaiodobenzylguanidine intra- and extravesicular accumulation in the rat heart.

1986 • 159 citations

Selective reduction of radiotracer trapping by deuterium substitution: comparison of carbon-11-L-deprenyl and carbon-11-deprenyl-D2 for MAO B mapping.

1995 • 155 citations

Carbon-11 hydroxyephedrine with positron emission tomography for serial assessment of cardiac adrenergic neuronal function after acute myocardial infarction in humans

1993 • 153 citations

PET scanning with hydroxyephedrine: an approach to the localization of pheochromocytoma.

1992 • 153 citations

The autonomic nervous system and sudden death.

1998 • 152 citations

Serial Assessment of Sympathetic Reinnervation After Orthotopic Heart Transplantation

1999 • 149 citations

6-Fluorocatecholamines as false adrenergic neurotransmitters.

1983 • 138 citations

Cardiac Sympathetic Denervation After Transmyocardial Laser Revascularization

1999 • 135 citations

Loss of 123I-MIBG uptake by the heart in Parkinson's disease: assessment of cardiac sympathetic denervation and diagnostic value.

1999 • 134 citations

Scintigraphic assessment of sympathetic innervation after transmural versus nontransmural myocardial infarction

1991 • 128 citations

Scintigraphic Assessment of Regionalized Defects in Myocardial Sympathetic Innervation and Blood Flow Regulation in Diabetic Patients With Autonomic Neuropathy

1998 • 128 citations

Current concepts on the diagnostic use of MIBG in children.

1998 • 124 citations

Positron emission tomographic imaging of cardiac sympathetic innervation and function.

1990 • 124 citations

Myocardial kinetics of carbon-11-meta-hydroxyephedrine: retention mechanisms and effects of norepinephrine.

1993 • 119 citations

Noninvasive assessment of cardiac diabetic neuropathy by carbon-11 hydroxyephedrine and positron emission tomography

1993 • 119 citations

Autonomic neuroeffector mechanisms

1992 • 116 citations

Regional In Vivo and In Vitro Characterization of Autonomic Innervation in Cardiomyopathic Human Heart

1998 • 108 citations

Improvement of cardiac neuronal function after carvedilol treatment in dilated cardiomyopathy: a 123I-MIBG scintigraphic study.

2000 • 107 citations

Imaging the adrenal medulla with an I-131-labeled antiadrenergic agent.

1979 • 104 citations

Evaluation of Sympathetic Nerve Terminals With [ ¹¹ C]Epinephrine and [ ¹¹ C]Hydroxyephedrine and Positron Emission Tomography

2000 • 99 citations

Uptake of meta-iodobenzylguanidine by bovine chromaffin granule membranes.

1986 • 98 citations

Regional patterns of myocardial sympathetic denervation in dilated cardiomyopathy: an analysis using carbon-11 hydroxyephedrine and positron emission tomography

1999 • 95 citations

Positron emission tomography of the heart

1985 • 92 citations

Treatment of Malignant Pheochromocytomas With 131-I Metaiodobenzylguanidine and Chemotherapy

1999 • 87 citations

Regression and progression of cardiac sympathetic dysinnervation complicating diabetes: An assessment by C-11 hydroxyephedrine and positron emission tomography

1999 • 86 citations

Metaiodobenzylguanidine scintigraphy of the heart: what have we learnt clinically?

2000 • 85 citations

Human autonomic pharmacology

1938 • 84 citations

Cardiac Electrophysiology

2009 • 82 citations

Clinical Application of Noradrenaline Spillover Methodology: Delineation of Regional Human Sympathetic Nervous Responses

1993 • 80 citations

PET hydroxyephedrine imaging of neuroblastoma.

1996 • 79 citations

Nuclear medicine imaging of pheochromocytoma and neuroblastoma.

1999 • 75 citations

Neuronal mapping of the heart with 6-[18F]fluorometaraminol

1990 • 73 citations

Asymmetry of cardiac [123I] meta-iodobenzyl-guanidine scans in patients with ventricular tachycardia and a "clinically normal" heart.

1993 • 72 citations

Uptake mechanisms of meta-[123I]iodobenzylguanidine in isolated rat heart

1995 • 70 citations

Cardiac 123I-MIBG uptake in idiopathic ventricular tachycardia and fibrillation.

1999 • 70 citations

Noradrenaline transporter gene transfer for radiation cell kill by 131I meta-iodobenzylguanidine

1999 • 68 citations

Incomplete sympathic reinnervation of the orthotopically transplanted human heart: Observation up to 13 years after heart transplantation

2000 • 67 citations

Synthesis of high specific activity (+)- and (-)-6-[18F]fluoronorepinephrine via the nucleophilic aromatic substitution reaction

1991 • 65 citations

Effect of glycaemic control on myocardial sympathetic innervation assessed by [ 123 I]metaiodobenzylguanidine scintigraphy: a 4-year prospective study in IDDM patients

1998 • 64 citations

Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines

1979 • 64 citations

Stereospecific deuterium substitution at the α-carbon position of dopamine and its effect on oxidative deamination catalyzed by MAO-A and MAO-B from different tissues

1986 • 60 citations

Synthesis of high specific activity 6-[18F]fluorodopamine for positron emission tomography studies of sympathetic nervous tissue

1991 • 60 citations

High yield synthesis of high specific activity R-(−)-[11C]epinephrine for routine PET studies in humans

1993 • 57 citations

Synthesis and preliminary evaluation of para- and meta-[18F]fluorobenzylguanidine

1994 • 55 citations

Diabetic autonomic neuropathy and the heart

1996 • 55 citations

Cardiac positron emission tomography imaging with [11c]hydroxyephedrine, a specific tracer for sympathetic nerve endings, and its functional correlates in congestive heart failure

1999 • 55 citations

Photochemistry of diazonium salts. 4. Synthesis of ring-fluorinated tyramines and dopamines

1976 • 54 citations

Validation of 4-[fluorine-18]fluoro-3-iodobenzylguanidine as a positron-emitting analog of MIBG.

1995 • 53 citations

Preparation and pharmacological characterization of [76Br]-meta-bromobenzylguanidine ([76Br]MBBG)

1994 • 52 citations

Effect of regional myocardial ischemia on sympathetic nervous system as assessed by fluorine-18-metaraminol.

1990 • 52 citations

6-[18F]fluorometaraminol. A radiotracer for in vivo mapping of adrenergic nerves of the heart

1988 • 50 citations

Myocardial perfusion and sympathetic innervation in patients with hypertrophic cardiomyopathy

2000 • 49 citations

Disposition of endogenous adrenaline compared to noradrenaline released by cardiac sympathetic nerves in the anaesthetized dog

1992 • 49 citations

Myocardial kinetics of carbon-11-epinephrine in the isolated working rat heart.

1997 • 48 citations

Cardiovascular Physiology

2002 • 45 citations

Clinical evaluation of carbon-11-phenylephrine: MAO-sensitive marker of cardiac sympathetic neurons.

1996 • 45 citations

The disposition of 3H-(−)noradrenaline in the Perfused cat and rabbit heart

1981 • 42 citations

Release of Tritiated Epinephrine following Sympathetic Nerve Stimulation

1964 • 41 citations

Kinetics of 123I-MIBG after acute myocardial infarction and reperfusion therapy.

1999 • 40 citations

Positron Emission Tomography of the Heart

1993 • 39 citations

The sympathetic nervous system in chronic heart failure

1998 • 39 citations

Radiopharmaceuticals. 12. New rapid synthesis of carbon-11-labeled norepinephrine hydrochloride

1974 • 37 citations

Saturation kinetics of the adrenergic neurone uptake system in the perfused rabbit heart. A new method for determination of initial rates of amine uptake

1978 • 36 citations

Autonomic pharmacology

1997 • 36 citations

Quantitation of presynaptic cardiac sympathetic function with carbon-11-meta-hydroxyephedrine.

1998 • 36 citations

Synthesis and preliminary evaluation of [11C]-(−)-phenylepnrine as a functional heart neuronal PET agent

1996 • 34 citations

131I MIBG therapy in neuroblastoma: Mechanisms, rationale, and current status

1999 • 33 citations

Bromine-76-metabromobenzylguanidine: a PET radiotracer for mapping sympathetic nerves of the heart.

1993 • 31 citations

Influence of vesicular storage and monoamine oxidase activity on [11C]phenylephrine kinetics: studies in isolated rat heart.

1999 • 30 citations

Mechanistic Positron Emission Tomography Studies of 6‐[¹⁸F]Fluorodopamine in Living Baboon Heart: Selective Imaging and Control of Radiotracer Metabolism Using the Deuterium Isotope Effect

1995 • 30 citations

Radioactive N,N‐Dimethylphenylethylamine: A Selective Radiotracer for In Vivo Measurement of Monoamine Oxidase‐B Activity in the Brain

1985 • 30 citations

Sensitivity of [11C]phenylephrine kinetics to monoamine oxidase activity in normal human heart.

1999 • 29 citations

Cardiac studies with metaiodobenzylguanidine: a critique of methods and interpretation of results.

1995 • 27 citations

Biodistribution and metabolism of [N-methyl-11C]-m-hydroxyphedrine in the rat

1997 • 25 citations

Organic radiopharmaceuticals labeled with isotopes of short half-life. I. 11C-1-dopamine hydrochloride.

1970 • 25 citations

Formation of α-methylnorepinephrine as a metabolite of metaraminol in guinea pigs

1981 • 24 citations

Uptake and retention kinetics of para-fluorine-18-fluorobenzylguanidine in isolated rat heart.

1996 • 23 citations

Selective synthesis of racemic 1-11C-labelled norepinephrine, octopamine, norphenylephrine and phenylethanolamine using [11C]nitromethane

1994 • 22 citations

Positron emission tomography shows high specific uptake of racemic carbon-11 labelled norepinephrine in the primate heart

1994 • 21 citations

High specific radioactivity (1R,2S)-4-[18F]fluorometaraminol: a PET radiotracer for mapping sympathetic nerves of the heart

2000 • 20 citations

Imaging of cardiac neuronal function after cocaine exposure using Carbon-11 hydroxyephedrine and positron emission tomography

1994 • 20 citations

Assessment of Myocardial Reinnervation in Cardiac Transplants by Positron Emission Tomography: Functional Significance Tested by Heart Rate Variability

1996 • 18 citations

Preparation of [1-11C]Dopamine, [1-11C]p-tyramine and [1-11C]m-tyramine. Autoradiography and PET examination of [1-11C]Dopamine in primates

1993 • 17 citations

[11C]Metaraminol, a false neurotransmitter: Preparation, metabolite studies and positron emission tomography examination in monkey

1996 • 16 citations

Synthesis of [¹¹C](−)‐α,α‐dideutero‐phenylephrine for in vivo kinetic isotope studies

1995 • 14 citations

Biodistribution and Metabolism of [N-methyl-11C]-m-hydroxyephedrine in the Rat

1997 • 14 citations

Para-[18F]fluorobenzylguanidine kinetics in a canine coronary artery occlusion model1

1996 • 13 citations

Kinetics of the norepinephrine analog [76Br]-metabromobenzylguanidine in isolated working rat heart

1998 • 13 citations

Species differences in monoamine oxidase-A and -B as revealed by sensitivity to trypsin

1984 • 12 citations

[13N]-β-phenethylamine ([13N]PEA): A prototype tracer for measurement of MAO-B activity in heart

1987 • 11 citations

Effects of specific activity on meta-[131I]iodobenzylguanidine kinetics in isolated rat heart

1998 • 10 citations

Metabolic fate of the heart agent [18F]6-fluorometaraminol

1989 • 10 citations

Determination of Transport Parameters of Permeant Substrates of the Vesicular Amine Transporter

1998 • 9 citations