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THE [¹⁴C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT¹

1977 • 5,986 citations

An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat

1978 • 1,887 citations

Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids

1972 • 1,164 citations

Serotonin Function and the Mechanism of Antidepressant Action

1990 • 911 citations

Brain metabolism: a perspective from the blood-brain barrier

1983 • 745 citations

Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects

1998 • 298 citations

Methods for quantifying the transport of drugs across brain barrier systems

1981 • 214 citations

EFFECT OF ALBUMIN BINDING AND AMINO ACID COMPETITION ON TRYPTOPHAN UPTAKE INTO BRAIN

1977 • 200 citations

Positron emission tomography imaging of serotonin transporters in the human brain using [¹¹C](+)McN5652

1995 • 175 citations

A New Method to Measure Brain Serotonin Synthesis in vivo. I. Theory and Basic Data for a Biological Model

1990 • 175 citations

Effect of tryptophan administration on tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human lumbar and cisternal cerebrospinal fluid.

1981 • 158 citations

Human brain serotonin synthesis capacity measured in vivo with ?-[C-11]methyl-L-tryptophan

1998 • 153 citations

α[C-11]Methyl-<scp>l</scp>-Tryptophan PET Maps Brain Serotonin Synthesis and Kynurenine Pathway Metabolism

2000 • 142 citations

Increased brain serotonin synthesis in migraine

1999 • 117 citations

A STUDY OF PROPOSED DETERMINANTS OF BRAIN TRYPTOPHAN CONCENTRATION IN RATS AFTER PORTOCAVAL ANASTOMOSIS OR SHAM OPERATION

1978 • 116 citations

Kynurenine Pathway Enzymes in Brain: Responses to Ischemic Brain Injury Versus Systemic Immune Activation

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Narcotic Drugs: Effects on the Serotonin Biosynthetic Systems of the Brain

1972 • 105 citations

Analysis of [^C-11]Alpha-Methyl-Tryptophan Kinetics for the Estimation of Serotonin Synthesis RateIn Vivo

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Kinetic Constants for Blood—Brain Barrier Amino Acid Transport in Conscious Rats

1985 • 103 citations

Stimulation of protein synthesis and glucose utilization in the hypoglossal nucleus induced by axotomy

1984 • 93 citations

A New Method to Measure Brain Serotonin Synthesis in vivo. II. A Practical Autoradiographic Method Tested in Normal and Lithium-Treated Rats

1990 • 90 citations

Serotonin 5HT₂ Receptor Imaging in the Human Brain Using Positron Emission Tomography and a New Radioligand, [¹⁸F]Altanserin: Results in Young Normal Controls

1995 • 87 citations

Serotonin Synthesis Rate Measured in Living Dog Brain by Positron Emission Tomography

1991 • 86 citations

The Involvement of Serotonin in Psychiatric Disorders and Behaviour

1988 • 83 citations

Influence of Fluoxetine on Regional Serotonin Synthesis in the Rat Brain

1996 • 77 citations

Effects of Acute and Chronic Administration of the Serotonin_1A Agonist Buspirone on Serotonin Synthesis in the Rat Brain

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The Suitability of [¹¹C]-α-Methyl-L-tryptophan as a Tracer for Serotonin Synthesis: Studies With Dual Administration of [¹¹C] and [¹⁴C] Labeled Tracer

2000 • 76 citations

Exogenous Tryptophan Increases Synthesis, Storage, and Intraneuronal Metabolism of 5‐Hydroxytryptamine in the Rat Hypothalamus

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1968 • 74 citations

Content of Quinolinic Acid and of Other Tryptophan Metabolites Increases in Brain Regions of Rats Used as Experimental Models of Hepatic Encephalopathy

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Determination of the Lumped Constant for the α‐Methyltryptophan Method of Estimating the Rate of Serotonin Synthesis

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Regulation of serotonin biosynthesis in brain: role of the high affinity uptake of tryptophan into serotonergic neurons.

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How does displacement of albumin-bound tryptophan cause sustained increases in the free tryptophan concentration in plasma and 5-hydroxytryptamine synthesis in brain?

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[ carbonyl - 11 C]Desmethyl-WAY-100635 (DWAY) is a potent and selective radioligand for central 5-HT 1A receptors in vitro and in vivo

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Detection of Hepatocellular Carcinoma: Combined T2-Weighted and Dynamic Gadolinium-Enhanced MRI Versus Combined CT During Arterial Portography and CT Hepatic Arteriography

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Retrograde axonal transport following injection of [3H]serotonin in the olfactory bulb. I. Biochemical study

1980 • 53 citations

A.E. Bennett Award Paper. A kinetic analysis of 5-hydroxyindoleacetic acid excretion from rat brain and csf.

1976 • 50 citations

Effects of Albumin, Amino Acids and Clofibrate on the Uptake of Tryptophan by the Rat Brain

1980 • 46 citations

REGIONAL TRANSPORT OF TRYPTOPHAN IN RAT BRAIN

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Rapid steady-state analysis of blood-brain transfer of l-Trp in rat, with special reference to the plasma protein binding

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Validation of a Less-Invasive Method for Measurement of Serotonin Synthesis Rate with α-[¹¹C]Methyl-Tryptophan

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Brain Serotonin Synthesis Rates in Rhesus Monkeys Determined by [11C]α-Methyl-?-Tryptophan and Positron Emission Tomography Compared to CSF 5-Hydroxyindole-3-Acetic Acid Concentrations

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Biochemical and Autoradiographic Measurements of Brain Serotonin Synthesis Rate in the Freely Moving Rat

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In vivo and in vitro activation of soluble tryptophan hydroxylase from rat brainstem

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Image Generation of Serotonin Synthesis Rates Using α-Methyltryptophan and PET

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Role of active transport of tryptophan in the control of 5-hydroxytryptamine biosynthesis.

1974 • 25 citations

Pharmacokinetics of alpha-methyl-L-tryptophan in rhesus monkeys and calculation of the lumped constant for estimating the rate of serotonin synthesis.

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Acute and chronic D-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: an autoradiographic study.

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Acute effects of 3,4-methylenedioxymethamphetamine on brain serotonin synthesis in the dog studied by positron emission tomography

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Failure of decreased serotonin uptake or monoamine oxidase inhibition to block the acceleration in brain 5-hydroxyindole synthesis that follows food consumption

1975 • 19 citations

dl-Fenfluramine increases the 5-HT synthesis rate in the terminals while decreasing it in the cell bodies of the rat brain

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Synthesis of α‐[¹⁴C]methyl and α‐[₃H]methyl‐L‐tryptophan

1993 • 10 citations

The effect of MDMA (3,4-methylenedioxymethamphetamine) on the 5-HT synthesis rate in the rat brain: an autoradiographic study

1998 • 9 citations

REPLY FROM P. BOBILLIER, P. CLEMENT, N. SARDA, AND A. GHARIB

1999 • 2 citations