Back to search

Hallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors

Data up to Jan 2025

Published2005
Citations33
References97

Total Citations Per Year

Abstract

References (97)

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains

2013 • 3,867 citations

[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors

1995 • 2,811 citations

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

2000 • 1,199 citations

Hallucinogens

2004 • 1,077 citations

Lecture notes in computational science and engineering

2010 • 822 citations

High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells

2005 • 724 citations

Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

2004 • 711 citations

MAP Kinase Phosphatase As a Locus of Flexibility in a Mitogen-Activated Protein Kinase Signaling Network

2002 • 647 citations

Area per Lipid and Acyl Length Distributions in Fluid Phosphatidylcholines Determined by 2H NMR Spectroscopy

2000 • 625 citations

Complexity in Biological Signaling Systems

1999 • 614 citations

Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6

2001 • 605 citations

Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes

2003 • 591 citations

Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus

1998 • 502 citations

A FlAsH-based FRET approach to determine G protein–coupled receptor activation in living cells

2005 • 480 citations

Structural Mimicry in G Protein-Coupled Receptors: Implications of the High-Resolution Structure of Rhodopsin for Structure-Function Analysis of Rhodopsin-Like Receptors

2001 • 442 citations

Computational Cell Biology

2004 • 418 citations

Activation of rhodopsin: new insights from structural and biochemical studies

2001 • 406 citations

β2 Adrenergic Receptor Activation

2002 • 405 citations

The Virtual Cell: a software environment for computational cell biology

2001 • 395 citations

Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor

2001 • 361 citations

RNA Editing of the Human Serotonin 5-Hydroxytryptamine 2C Receptor Silences Constitutive Activity

1999 • 353 citations

Serotonin and Hallucinogens

1999 • 343 citations

Role of the conserved NPxxY(x) 5,6 F motif in the rhodopsin ground state and during activation

2003 • 337 citations

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

2000 • 329 citations

Agonist-induced conformational changes in the G-protein-coupling domain of the β 2 adrenergic receptor

2001 • 311 citations

Targeted gene expression in dopamine and serotonin neurons of the mouse brain

2004 • 298 citations

Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex

2003 • 279 citations

Molecular Biology of Serotonin Receptors - Structure and Function at the Molecular Level

2002 • 269 citations

The statistical mechanics of complex signaling networks: nerve growth factor signaling

2004 • 265 citations

G Protein-Coupled Receptor Rhodopsin: A Prospectus

2003 • 255 citations

Quantitative cell biology with the Virtual Cell☆

2003 • 252 citations

Functional Microdomains in G-protein-coupled Receptors

1998 • 238 citations

Specific Tryptophan UV-Absorbance Changes Are Probes of the Transition of Rhodopsin to Its Active State

1996 • 226 citations

Quantitative analysis of signaling networks

2004 • 221 citations

The second extracellular loop of the dopamine D2receptor lines the binding-site crevice

2004 • 200 citations

Adhesion Forces of Lipids in a Phospholipid Membrane Studied by Molecular Dynamics Simulations

1998 • 197 citations

Computational cell biology

2003 • 185 citations

PDZBase: a protein–protein interaction database for PDZ-domains

2004 • 185 citations

An Aromatic Microdomain at the Cannabinoid CB1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region

2003 • 184 citations

Functional Selectivity of G Protein Signaling by Agonist Peptides and Thrombin for the Protease-activated Receptor-1

2005 • 181 citations

Selective 5ht-2 antagonists inhibit serotonin stimulated phosphatidylinositol metabolism in cerebral cortex

1984 • 179 citations

Evidence for a Model of Agonist-induced Activation of 5-Hydroxytryptamine 2A Serotonin Receptors That Involves the Disruption of a Strong Ionic Interaction between Helices 3 and 6

2002 • 177 citations

Three-dimensional representations of G protein-coupled receptor structures and mechanisms

2002 • 173 citations

An Alamethicin Channel in a Lipid Bilayer: Molecular Dynamics Simulations

1999 • 172 citations

A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface

2004 • 171 citations

A Cluster of Aromatic Residues in the Sixth Membrane-Spanning Segment of the Dopamine D2 Receptor Is Accessible in the Binding-Site Crevice

1998 • 159 citations

Receptor activation: what does the rhodopsin structure tell us?

2001 • 156 citations

Serotonin 5-Hydroxytryptamine2AReceptor-Coupled Phospholipase C and Phospholipase A2Signaling Pathways Have Different Receptor Reserves

2003 • 155 citations

Structural Mimicry in Class A G Protein-coupled Receptor Rotamer Toggle Switches

2004 • 148 citations

Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover

1984 • 146 citations

Molecular basis of inverse agonism in a G protein–coupled receptor

2005 • 144 citations

The Crystallographic Model of Rhodopsin and Its Use in Studies of Other G Protein–Coupled Receptors

2003 • 134 citations

Computational Cell Biology: Spatiotemporal Simulation of Cellular Events

2002 • 133 citations

Functional Selectivity of Dopamine Receptor Agonists. I. Selective Activation of Postsynaptic Dopamine D2Receptors Linked to Adenylate Cyclase

2002 • 121 citations

Conserved Helix 7 Tyrosine Acts as a Multistate Conformational Switch in the 5HT2C Receptor

2002 • 119 citations

A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: the involvement of MAP kinases

2003 • 117 citations

The study of G‐protein coupled receptor oligomerization with computational modeling and bioinformatics

2005 • 107 citations

Rhodopsin Activation Exposes a Key Hydrophobic Binding Site for the Transducin α-Subunit C Terminus

2004 • 102 citations

The Ants Go Marching Two by Two: Oligomeric Structure of G-Protein-Coupled Receptors

2004 • 97 citations

Opioid receptor random mutagenesis reveals a mechanism for G protein–coupled receptor activation

2003 • 93 citations

Structural Basis for Activation of G‐Protein‐Coupled Receptors

2002 • 91 citations

Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method

2002 • 88 citations

Functional Selectivity of D2Receptor Ligands in a Chinese Hamster Ovary hD2LCell Line: Evidence for Induction of Ligand-Specific Receptor States

2004 • 86 citations

Activation of the cannabinoid CB1 receptor may involve a W6.48/F3.36 rotamer toggle switch

2002 • 85 citations

Functional Role of a Conserved Motif in TM6 of the Rat μ Opioid Receptor: Constitutively Active and Inactive Receptors Result from Substitutions of Thr6.34(279) with Lys and Asp

2001 • 84 citations

The Functional Microdomain in Transmembrane Helices 2 and 7 Regulates Expression, Activation, and Coupling Pathways of the Gonadotropin-releasing Hormone Receptor

1999 • 83 citations

[20] Detergents for extraction of visual pigments: Types, solubilization, and stability

1982 • 82 citations

Structural models for dimerization of G‐protein coupled receptors: The opioid receptor homodimers

2002 • 80 citations

A knowledge-based scale for the analysis and prediction of buried and exposed faces of transmembrane domain proteins

2004 • 77 citations

An Activation Switch in the Ligand Binding Pocket of the C5a Receptor

2001 • 77 citations

Molecular Determinants for the Complex Binding Specificity of the PDZ Domain in PICK1

2005 • 77 citations

Molecular Basis of Partial Agonism: Orientation of Indoleamine Ligands in the Binding Pocket of the Human Serotonin 5-HT2A Receptor Determines Relative Efficacy

2003 • 73 citations

Update on current concepts of the molecular basis of β2-adrenergic receptor signaling

2002 • 72 citations

Lysergic acid diethylamide-induced Fos expression in rat brain: role of serotonin-2A receptors

2002 • 67 citations

Spatial Distribution of Calcium Entry Evoked by Single Action Potentials within the Presynaptic Active Zone

2004 • 66 citations

Crystal Structure of Rhodopsin: A G-Protein-Coupled Receptor

2002 • 65 citations

Molecular dynamics simulations of peptides and proteins with a continuum electrostatic model based on screened Coulomb potentials

2003 • 64 citations

Mutation of Tyrosine in the Conserved NPXXY Sequence Leads to Constitutive Phosphorylation and Internalization, but Not Signaling, of the Human B2 Bradykinin Receptor

2004 • 61 citations

Key issues in the computational simulation of GPCR function: representation of loop domains.

2002 • 55 citations

RNA Editing of the Human Serotonin 5-HT2CReceptor Disrupts Transactivation of the Small G-Protein RhoA

2004 • 51 citations

Structural motifs as functional microdomains in G‐protein‐coupled receptors: Energetic considerations in the mechanism of activation of the serotonin 5‐HT2A receptor by disruption of the ionic lock of the arginine cage*

2002 • 49 citations

Serotonin Receptors and Phosphatidylinositol Turnovera

1990 • 47 citations

Molecular Dynamics Simulations Predict a Tilted Orientation for the Helical Region of Dynorphin A(1–17) in Dimyristoylphosphatidylcholine Bilayers

2000 • 45 citations

Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the μ opioid receptor

1999 • 43 citations

New Lessons From Knockout Mice: The Role of Serotonin During Development and Its Possible Contribution to the Origins of Neuropsychiatric Disorders

2003 • 43 citations

Decreased Serotonin 5-HT2A Receptor-Stimulated Phosphoinositide Signaling in Fibroblasts from Melancholic Depressed Patients

2004 • 42 citations

Quantitative Information Management for the Biochemical Computation of Cellular Networks

2004 • 41 citations

Receptor Molecular Biology

1995 • 40 citations

Differences in conformational properties of the second intracellular loop (IL2) in 5HT2C receptors modified by RNA editing can account for G protein coupling efficiency

2001 • 38 citations

Surface Tension Parameterization in Molecular Dynamics Simulations of a Phospholipid-bilayer Membrane: Calibration and Effects

2004 • 22 citations

Structure Calculation of Protein Segments Connecting Domains with Defined Secondary Structure: A Simulated Annealing Monte Carlo Combined with Biased Scaled Collective Variables Technique

2002 • 20 citations

Positioning and Stabilization of Dynorphin Peptides in Membrane Bilayers: the Mechanistic Role of Aromatic and Basic Residues Revealed from Comparative MD Simulations

2001 • 20 citations

The Virtual Cell Project

2010 • 18 citations

Strategies for mapping the binding site of the serotonin 5-HT2A receptor

2002 • 11 citations

Mechanistic Insights from a Refined Three-dimensional Model of Integrin αIIbβ3

2004 • 10 citations

Modular interaction strengths in regulatory networks; an example.

2002 • 8 citations

Cited By (0)

No citing papers found in database

Hallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and… (2005) – The AAPS Journal | Metascience Observatory Explorer