A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Seven-transmembrane receptors

2002 • 2,571 citations

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

2000 • 1,199 citations

G-protein-coupled receptor heterodimerization modulates receptor function

1999 • 1,146 citations

The Many Faces of G Protein Signaling

1998 • 1,137 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

The structure of the G protein heterotrimer Giα1β1γ2

1995 • 1,091 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G _sα ·GTPγS

1997 • 780 citations

Crystal structure of a GA protein βγdimer at 2.1 Å resolution

1996 • 741 citations

Rhodopsin dimers in native disc membranes

2003 • 734 citations

Roles of G‐protein‐coupled receptor dimerization

2004 • 668 citations

Structural determinants for activation of the α-subunit of a heterotrimeric G protein

1994 • 636 citations

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)^,

2001 • 598 citations

Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes

2003 • 591 citations

G-Protein-coupled receptor oligomerization and its potential for drug discovery

2002 • 584 citations

Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function

2002 • 580 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

2000 • 487 citations

Increased AT1 receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness

2001 • 485 citations

The Angiotensin II AT2 Receptor Is an AT1Receptor Antagonist

2001 • 459 citations

Structural Mimicry in G Protein-Coupled Receptors: Implications of the High-Resolution Structure of Rhodopsin for Structure-Function Analysis of Rhodopsin-Like Receptors

2001 • 442 citations

A Model for Arrestin’s Regulation: The 2.8 Å Crystal Structure of Visual Arrestin

1999 • 414 citations

Activation of rhodopsin: new insights from structural and biochemical studies

2001 • 406 citations

Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ

2003 • 373 citations

Sequence Analyses of G-Protein-Coupled Receptors: Similarities to Rhodopsin

2003 • 342 citations

Role of the conserved NPxxY(x) _5,6 F motif in the rhodopsin ground state and during activation

2003 • 337 citations

How photons start vision.

1996 • 326 citations

Assembly of functional rhodopsin requires a disulfide bond between cysteine residues 110 and 187.

1990 • 320 citations

Heterotrimeric G proteins

1996 • 318 citations

G-protein-coupled receptor dimerization: modulation of receptor function

2001 • 307 citations

Turned on by Ca2+! The physiology and pathology of Ca2+-binding proteins in the retina

1996 • 287 citations

Structure-based Analysis of GPCR Function: Evidence for a Novel Pentameric Assembly between the Dimeric Leukotriene B4 Receptor BLT1 and the G-protein

2003 • 270 citations

G Protein-Coupled Receptor Rhodopsin: A Prospectus

2003 • 255 citations

Dual Inhibition of β-Adrenergic and Angiotensin II Receptors by a Single Antagonist

2003 • 239 citations

X-ray crystal structure of arrestin from bovine rod outer segments

1998 • 236 citations

A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments

1979 • 232 citations

The G protein‐coupled receptor rhodopsin in the native membrane

2004 • 224 citations

Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins.

1979 • 211 citations

The second extracellular loop of the dopamine D₂receptor lines the binding-site crevice

2004 • 200 citations

Scaffolding Functions of Arrestin-2 Revealed by Crystal Structure and Mutagenesis^,

2002 • 194 citations

G Protein–Coupled Receptor Oligomerization

2004 • 193 citations

G-protein diseases furnish a model for the turn-on switch

1998 • 192 citations

Membrane protein diffusion sets the speed of rod phototransduction

2001 • 179 citations

THE VISUAL CELLS AND VISUAL PIGMENT OF THE MUDPUPPY, NECTURUS

1963 • 174 citations

G protein coupled receptor dimerization: implications in modulating receptor function

2001 • 173 citations

Dimerization of G-protein-coupled receptors: roles in signal transduction

2003 • 166 citations

Phototransduction: crystal clear

2003 • 160 citations

Mutation of the Fourth Cytoplasmic Loop of Rhodopsin Affects Binding of Transducin and Peptides Derived from the Carboxyl-terminal Sequences of Transducin α and γ Subunits

2000 • 159 citations

Light-activated rhodopsin induces structural binding motif in G protein α subunit

1998 • 149 citations

Structural Properties of a Highly Polyunsaturated Lipid Bilayer from Molecular Dynamics Simulations

2001 • 144 citations

Mapping of contact sites in complex formation between transducin and light-activated rhodopsin by covalent crosslinking: Use of a photoactivatable reagent

2001 • 137 citations

Oligomerization, Biogenesis, and Signaling Is Promoted by a Glycophorin A-like Dimerization Motif in Transmembrane Domain 1 of a Yeast G Protein-coupled Receptor

2003 • 136 citations

The Crystallographic Model of Rhodopsin and Its Use in Studies of Other G Protein–Coupled Receptors

2003 • 134 citations

The Amino Terminus of the Fourth Cytoplasmic Loop of Rhodopsin Modulates Rhodopsin-Transducin Interaction

2000 • 133 citations

Mapping the Arrestin-Receptor Interface

2004 • 127 citations

Oligomerisation of G-protein-coupled receptors

2001 • 124 citations

Lipid metabolism in vertebrate retinal rod outer segments

2000 • 122 citations

Crystal structure of rhodopsin: implications for vision and beyond

2001 • 121 citations

Mechanism of GTP hydrolysis by G-protein alpha subunits.

1994 • 117 citations

Dimers of Class A G Protein-coupled Receptors Function via Agonist-mediated Trans-activation of Associated G Proteins

2003 • 111 citations

Light- and Guanosine 5′-3-O-(Thio)triphosphate-sensitive Localization of a G Protein and Its Effector on Detergent-resistant Membrane Rafts in Rod Photoreceptor Outer Segments

2001 • 103 citations

Mapping of contact sites in complex formation between light-activated rhodopsin and transducin by covalent crosslinking: Use of a chemically preactivated reagent

2001 • 101 citations

Signal-Dependent Translocation of Transducin, RGS9-1-Gβ5L Complex, and Arrestin to Detergent-Resistant Membrane Rafts in Photoreceptors

2002 • 97 citations

Activation of G-protein Gα subunits by receptors through Gα–Gβ and Gα–Gγ interactions

2003 • 93 citations

Homo- and hetero-oligomerization of G protein-coupled receptors

2003 • 90 citations

Signal transduction: Evolution of an idea

1995 • 89 citations

Structure and functions of arrestins

1994 • 86 citations

Transducin-α C-terminal Peptide Binding Site Consists of C-D and E-F Loops of Rhodopsin

1997 • 84 citations

GPCR dimerisation

2003 • 81 citations

Mutant G protein α subunit activated by Gβγ: A model for receptor activation?

2001 • 76 citations

Conformational Changes of G Protein‐Coupled Receptors During Their Activation by Agonist Binding

2003 • 69 citations

Heterodimerization of Type A and B Cholecystokinin Receptors Enhance Signaling and Promote Cell Growth

2003 • 64 citations

Functional Characterization of a Series of Mutant G Protein αq Subunits Displaying Promiscuous Receptor Coupling Properties

1998 • 63 citations

Structure of Giα1·GppNHp, Autoinhibition in a Gα Protein-Substrate Complex

1999 • 53 citations

Cholesterol-Dependent Association of Caveolin-1 with the Transducin α Subunit in Bovine Photoreceptor Rod Outer Segments: Disruption by Cyclodextrin and Guanosine 5‘-O-(3-Thiotriphosphate)

2003 • 48 citations

Light-Mediated Activation of Rac-1 in Photoreceptor Outer Segments

2003 • 36 citations

Rhodopsin-Transducin Interface: Studies with Conformationally Constrained Peptides

2001 • 36 citations

Molecular interactions between the photoreceptor G protein and rhodopsin

1991 • 27 citations

Evolutionary analysis of rhodopsin and cone pigments: connecting the three‐dimensional structure with spectral tuning and signal transfer

2003 • 19 citations

Is rhodopsin dimeric in native retinal rods?

2003 • 14 citations

Mont Sainte‐Odile: a sanctuary for GPCRs

2003 • 12 citations

The crystallographic structure of a G protein heterotrimer

1996 • 2 citations

Deleted Work

1955 • 0 citations