New Lessons From Knockout Mice: The Role of Serotonin During Development and Its Possible Contribution to the Origins of Neuropsychiatric Disorders

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

1996 • 5,154 citations

Role of Genotype in the Cycle of Violence in Maltreated Children

2002 • 4,796 citations

Serotonin Transporter Genetic Variation and the Response of the Human Amygdala

2002 • 2,332 citations

Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamine Oxidase A

1993 • 1,620 citations

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

1995 • 1,211 citations

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

2002 • 901 citations

Enhanced Aggressive Behavior in Mice Lacking 5-HT _1B Receptor

1994 • 823 citations

Serotonin receptor 1A knockout: An animal model of anxiety-related disorder

1998 • 802 citations

Elevated anxiety and antidepressant-like responses in serotonin 5-HT _1A receptor mutant mice

1998 • 690 citations

Increased anxiety of mice lacking the serotonin _1A receptor

1998 • 684 citations

A Serotonin Transporter Gene Promoter Polymorphism (5-HTTLPR) and Prefrontal Cortical Binding in Major Depression and Suicide

2000 • 603 citations

Lack of Barrels in the Somatosensory Cortex of Monoamine Oxidase A–Deficient Mice: Role of a Serotonin Excess during the Critical Period

1996 • 513 citations

Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice

2001 • 499 citations

Pet-1 ETS Gene Plays a Critical Role in 5-HT Neuron Development and Is Required for Normal Anxiety-like and Aggressive Behavior

2003 • 453 citations

The Neurobiology and Genetics of Suicide and Attempted Suicide: A Focus on the Serotonergic System

2001 • 390 citations

Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor

1998 • 329 citations

Evaluation of Antidepressant-related Behavioral Responses in Mice Lacking the Serotonin Transporter

2002 • 287 citations

Serotonin Receptors and Animal Models of Aggressive Behavior

1995 • 283 citations

Altered expression and functions of serotonin 5‐HT_1A and 5‐HT_1B receptors in knock‐out mice lacking the 5‐HT transporter

2000 • 271 citations

Altered Emotional States in Knockout Mice Lacking 5-HT1A or 5-HT1B Receptors

1999 • 269 citations

Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice

2001 • 264 citations

Reduced aggression in mice lacking the serotonin transporter

2002 • 247 citations

Brain serotonin, type II alcoholism and impulsive violence.

1993 • 214 citations

Genetic perspectives on the serotonin transporter

2001 • 209 citations

Induction of chronic Fos-related antigens in rat brain by chronic morphine administration.

1996 • 206 citations

5-HT1 receptor knock out — behavioral consequences

1995 • 201 citations

Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice.

2001 • 199 citations

Clinical utility of the selective serotonin reuptake inhibitors in the spectrum of anxiety

1998 • 192 citations

Genetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety.

2000 • 184 citations

How does pindolol improve antidepressant action?

2001 • 172 citations

Association between violent suicidal behavior and the low activity allele of the serotonin transporter gene

2001 • 166 citations

Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims

1999 • 164 citations

Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders

2000 • 157 citations

Rethinking Behavior Genetics

2002 • 154 citations

Genetic Inactivation of the Serotonin_1AReceptor in Mice Results in Downregulation of Major GABA_AReceptor α Subunits, Reduction of GABA_AReceptor Binding, and Benzodiazepine-Resistant Anxiety

2000 • 153 citations

Alcohol drinking produces brain region-selective changes in expression of inducible transcription factors

1999 • 148 citations

Genetics of Pathological Gambling

2003 • 134 citations

Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice

2001 • 132 citations

Effects of monoamine oxidase A inhibition on barrel formation in the mouse somatosensory cortex: Determination of a sensitive developmental period

1998 • 131 citations

Commentary: The broken mouse: the role of development, plasticity and environment in the interpretation of phenotypic changes in knockout mice

2000 • 121 citations

Targeted gene deletion of the 5-HT3A receptor subunit produces an anxiolytic phenotype in mice

2003 • 113 citations

Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists

2000 • 98 citations

5‐HT_1A receptor mutant mice exhibit enhanced tonic, stress‐induced and fluoxetine‐induced serotonergic neurotransmission

2001 • 92 citations

5‐HT_1B Autoreceptors limit the effects of selective serotonin re‐uptake inhibitors in mouse hippocampus and frontal cortex

2001 • 87 citations

A Gender-Specific Association between the Serotonin Transporter Gene and Suicide Attempts

2002 • 80 citations

Molecular manipulations as tools for enhancing our understanding of 5-HT neurotransmission

1999 • 72 citations

Decreased intracranial self-stimulation in a new animal model of endogenous depression

1990 • 68 citations

Modification of serotonin neuron properties in mice lacking 5-HT1A receptors

2002 • 68 citations

Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor

1998 • 67 citations

5‐HT Receptor Knockout Mice: Pharmacological Tools or Models of Psychiatric Disorders

1999 • 64 citations

mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons

2002 • 63 citations

Lack of 5-HT1B receptor and of serotonin transporter have different effects on the segregation of retinal axons in the lateral geniculate nucleus compared to the superior colliculus

2002 • 59 citations

Mouse models of serotonin receptor function: toward a genetic dissection of serotonin systems

2000 • 57 citations

Extracellular serotonin in the prefrontal cortex is limited through terminal 5-HT1B autoreceptors: a microdialysis study in knockout mice

2002 • 45 citations

Association Between Serotonin Transporter Gene Polymorphism and Family History of Attempted and Completed Suicide

2002 • 34 citations

Anxiolytic-like effects of DAIZAC, a selective high-affinity 5-HT3 receptor antagonist, in the mouse elevated plus-maze

2001 • 24 citations

Mutational Analysis of the Serotonergic System: Recent Findings Using Knockout Mice

2002 • 20 citations

Effect of Acute and Chronic Administration of Methamphetamine on Activator Protein‐1 Binding Activities in the Rat Brain Regions^a

1996 • 12 citations