G Protein-Coupled Receptor Rhodopsin: A Prospectus

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments

1986 • 1,702 citations

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

2000 • 1,199 citations

Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

1996 • 1,159 citations

G-protein-coupled receptors and signaling networks: emerging paradigms

2001 • 1,005 citations

The Molecular Basis of Visual Excitation

1968 • 813 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Projection structure of rhodopsin

1993 • 758 citations

Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin

1983 • 689 citations

Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.

1989 • 663 citations

Functional role of internal water molecules in rhodopsin revealed by x-ray crystallography

2002 • 662 citations

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors 1 1Edited by R. Huber

1997 • 639 citations

Vibrationally Coherent Photochemistry in the Femtosecond Primary Event of Vision

1994 • 624 citations

Tautomeric Forms of Metarhodopsin

1963 • 602 citations

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)^,

2001 • 598 citations

Predicting the orientation of eukaryotic membrane-spanning proteins.

1989 • 596 citations

Helical Membrane Protein Folding, Stability, and Evolution

2000 • 585 citations

Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function

2002 • 580 citations

Adaptation in Vertebrate Photoreceptors

2001 • 551 citations

Retinopathy induced in mice by targeted disruption of the rhodopsin gene

1997 • 527 citations

Fast prediction and visualization of protein binding pockets with PASS.

2000 • 521 citations

The structure of bovine rhodopsin

1983 • 513 citations

Isolation and nucleotide sequence of the gene encoding human rhodopsin.

1984 • 495 citations

Isolation and structure of a rhodopsin gene from D. melanogaster

1985 • 481 citations

Spectral Tuning of Pigments Underlying Red-Green Color Vision

1991 • 478 citations

Effect of Carboxylic Acid Side Chains on the Absorption Maximum of Visual Pigments

1989 • 469 citations

Molecular determinants of human red/green color discrimination

1994 • 462 citations

Expression of a synthetic bovine rhodopsin gene in monkey kidney cells.

1987 • 444 citations

Structural Mimicry in G Protein-Coupled Receptors: Implications of the High-Resolution Structure of Rhodopsin for Structure-Function Analysis of Rhodopsin-Like Receptors

2001 • 442 citations

Rhodopsin and bacteriorhodopsin: structure—function relationships

1982 • 430 citations

A Null mutation in the rhodopsin gene causes rod photoreceptor dysfunction and autosomal recessive retinitis pigmentosa

1992 • 417 citations

Vertebrate Photoreceptors

2001 • 410 citations

Two adjacent cysteine residues in the C‐terminal cytoplasmic fragment of bovine rhodopsin are palmitylated

1988 • 409 citations

Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin.

1988 • 409 citations

Activation of rhodopsin: new insights from structural and biochemical studies

2001 • 406 citations

Morphological, physiological, and biochemical changes in rhodopsin knockout mice

1999 • 391 citations

Photolyzed rhodopsin catalyzes the exchange of GTP for bound GDP in retinal rod outer segments.

1980 • 391 citations

Rhodopsin Mutants That Bind But Fail to Activate Transducin

1990 • 377 citations

Structure and Function in Rhodopsin

1995 • 375 citations

Light dependent phosphorylation of rhodopsin by ATP

1972 • 370 citations

Confronting Complexity: the Interlink of Phototransduction and Retinoid Metabolism in the Vertebrate Retina

2001 • 364 citations

Absorption spectra of human cone pigments

1992 • 360 citations

Site of Attachment of Retinal in Rhodopsin

1967 • 352 citations

A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment

1994 • 338 citations

Phosphorylation of Frog Photoreceptor Membranes induced by Light

1972 • 332 citations

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

2000 • 329 citations

CAROTENOIDS AND THE VISUAL CYCLE

1935 • 321 citations

Assembly of functional rhodopsin requires a disulfide bond between cysteine residues 110 and 187.

1990 • 320 citations

Determinants of visual pigment absorbance: identification of the retinylidene Schiff's base counterion in bovine rhodopsin

1990 • 319 citations

Structure and Function in Rhodopsin. 7. Point Mutations Associated with Autosomal Dominant Retinitis Pigmentosa

1994 • 309 citations

Mechanism of rhodopsin kinase activation

1991 • 301 citations

Rhodopsin: Structural Basis of Molecular Physiology

2001 • 301 citations

Turned on by Ca2+! The physiology and pathology of Ca2+-binding proteins in the retina

1996 • 287 citations

Structural Prediction of Membrane‐Bound Proteins

1982 • 285 citations

Predicting the topology of eukaryotic membrane proteins

1993 • 272 citations

Photoisomerization, energy storage, and charge separation: A model for light energy transduction in visual pigments and bacteriorhodopsin

1979 • 270 citations

X-ray structure of sensory rhodopsin II at 2.1-Å resolution

2001 • 269 citations

Molecular genetics of retinitis pigmentosa

1995 • 255 citations

ATP mediates rapid reversal of cyclic GMP phosphodiesterase activation in visual receptor membranes

1980 • 251 citations

Interactions between photoexcited rhodopsin and GTP-binding protein: kinetic and stoichiometric analyses from light-scattering changes.

1981 • 247 citations

Visual pigment: G-protein-coupled receptor for light signals

1998 • 243 citations

Photoisomerization by Hula-Twist: A Fundamental Supramolecular Photochemical Reaction

2001 • 242 citations

The photosensitivities of visual pigments in the presence of hydroxylamine

1968 • 240 citations

Molecular Genetics of Human Retinal Disease

1999 • 232 citations

Projection structure of frog rhodopsin in two crystal forms.

1995 • 220 citations

G-protein-coupled receptor kinases

1991 • 219 citations

Movement of Retinal Along the Visual Transduction Path

2000 • 218 citations

Energy uptake in the first step of visual excitation

1979 • 216 citations

Structure and function in rhodopsin: the role of asparagine-linked glycosylation.

1994 • 215 citations

Absorption Spectra of the Hybrid Pigments Responsible for Anomalous Color Vision

1992 • 212 citations

Acylation of bovine rhodopsin by [3H]palmitic acid.

1984 • 200 citations

Identification of an Outer Segment Targeting Signal in the Cooh Terminus of Rhodopsin Using Transgenic Xenopus laevis

2000 • 196 citations

X-Ray Diffraction Analysis of Three-Dimensional Crystals of Bovine Rhodopsin Obtained from Mixed Micelles

2000 • 194 citations

Mapping of the amino acids in membrane-embedded helices that interact with the retinal chromophore in bovine rhodopsin

1991 • 193 citations

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.

1991 • 189 citations

Total synthesis of a gene for bovine rhodopsin.

1986 • 179 citations

Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man

1998 • 177 citations

Rhodopsin Phosphorylation and Dephosphorylation in Vivo

1995 • 176 citations

Retinal Function and Rhodopsin Levels in Autosomal Dominant Retinitis Pigmentosa With Rhodopsin Mutations

1991 • 168 citations

Phosphorylation of rhodopsin and quenching of cyclic GMP phosphodiesterase activation by ATP at weak bleaches.

1983 • 165 citations

Mutation of the Fourth Cytoplasmic Loop of Rhodopsin Affects Binding of Transducin and Peptides Derived from the Carboxyl-terminal Sequences of Transducin α and γ Subunits

2000 • 159 citations

[23] Purification of rhodopsin by concanavalin A affinity chromatography

1982 • 157 citations

Receptor activation: what does the rhodopsin structure tell us?

2001 • 156 citations

Red, Green, and Red-Green Hybrid Pigments in the Human Retina: Correlations between Deduced Protein Sequences and Psychophysically Measured Spectral Sensitivities

1998 • 156 citations

Palmitoylation of bovine opsin and its cysteine mutants in COS cells.

1993 • 155 citations

Ca2+-binding proteins in the retina: Structure, function, and the etiology of human visual diseases

2000 • 153 citations

Design, chemical synthesis, and expression of genes for the three human color vision pigments

1991 • 151 citations

Purification and characterization of rhodopsin kinase.

1988 • 149 citations

The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints

1997 • 147 citations

Light-stimulated Phosphorylation of Bovine Visual Pigments by Adenosine Triphosphate

1973 • 143 citations

Identification of the chloride-binding site in the human red and green color vision pigments

1993 • 139 citations

ROLE OF HYDROXYL‐BEARING AMINO ACIDS IN DIFFERENTIALLY TUNING THE ABSORPTION SPECTRA OF THE HUMAN RED AND GREEN CONE PIGMENTS

1993 • 137 citations

Single amino acid residue as a functional determinant of rod and cone visual pigments

1997 • 136 citations

The Amino Terminus of the Fourth Cytoplasmic Loop of Rhodopsin Modulates Rhodopsin-Transducin Interaction

2000 • 133 citations

Effects of lipid environment on the light-induced conformational changes of rhodopsin. 2. Roles of lipid chain length, unsaturation, and phase state

1985 • 132 citations

Structural and Enzymatic Aspects of Rhodopsin Phosphorylation

1996 • 127 citations

Structure and function in rhodopsin: replacement by alanine of cysteine residues 110 and 187, components of a conserved disulfide bond in rhodopsin, affects the light-activated metarhodopsin II state.

1994 • 126 citations

Identification of Glutamic Acid 113 as the Schiff Base Proton Acceptor in the Metarhodopsin II Photointermediate of Rhodopsin

1994 • 125 citations

Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors

2002 • 123 citations

Crystal structure of rhodopsin: implications for vision and beyond

2001 • 121 citations

G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin.

2001 • 119 citations

The amino‐ and carboxyl‐terminal sequence of bovine rhodopsin

1977 • 118 citations

Chapter 1 Rhodopsin chemistry, structure and topography

1982 • 115 citations

Transducin Activation by Rhodopsin Without a Covalent Bond to the 11- Cis -Retinal Chromophore

1991 • 114 citations

Activating Mutations of Rhodopsin and Other G Protein-Coupled Receptors

1996 • 113 citations

Orientation of retinal in bovine rhodopsin determined by cross-linking using a photoactivatable analog of 11-cis-retinal.

1990 • 112 citations

Histidine residues regulate the transition of photoexcited rhodopsin to its active conformation, metarhodopsin II

1992 • 111 citations

Mechanisms of Opsin Activation

1996 • 109 citations

Deprotonation of the Schiff base of rhodopsin is obligate in the activation of the G protein.

1986 • 108 citations

In vivo assembly of rhodopsin from expressed polypeptide fragments.

1995 • 103 citations

Signal transfer from rhodopsin to the G-protein: Evidence for a two-site sequential fit mechanism

1999 • 101 citations

Structure and Function in Rhodopsin: Mapping Light-Dependent Changes in Distance between Residue 316 in Helix 8 and Residues in the Sequence 60−75, Covering the Cytoplasmic End of Helices TM1 and TM2 and Their Connection Loop CL1

2001 • 100 citations

Opsin expression in the rat retina is developmentally regulated by transcriptional activation.

1988 • 98 citations

Structure and Function in Rhodopsin: Mapping Light-Dependent Changes in Distance between Residue 65 in Helix TM1 and Residues in the Sequence 306−319 at the Cytoplasmic End of Helix TM7 and in Helix H8

2001 • 96 citations

Transverse location of the retinal chromophore of rhodopsin in rod outer segment disc membranes

1982 • 96 citations

Light-stable rhodopsin. I. A rhodopsin analog reconstituted with a nonisomerizable 11-cis retinal derivative.

1992 • 91 citations

Structure and function in rhodopsin: Rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state

1997 • 89 citations

The electroretinogram of the rhodopsin knockout mouse

1999 • 88 citations

Structure and functions of arrestins

1994 • 86 citations

Structural Features of the C-Terminal Domain of Bovine Rhodopsin: A Site-Directed Spin-Labeling Study^,

1999 • 84 citations

Function of Extracellular Loop 2 in Rhodopsin: Glutamic Acid 181 Modulates Stability and Absorption Wavelength of Metarhodopsin II

2002 • 84 citations

A Functional Rhodopsin-Green Fluorescent Protein Fusion Protein Localizes Correctly in Transgenic Xenopus laevis Retinal Rods and Is Expressed in a Time-dependent Pattern

2001 • 82 citations

Characterization of Rhodopsin Mutants That Bind Transducin but Fail to Induce GTP Nucleotide Uptake

1995 • 81 citations

Light-stable rhodopsin. II. An opsin mutant (TRP-265—-Phe) and a retinal analog with a nonisomerizable 11-cis configuration form a photostable chromophore.

1992 • 77 citations

Three-dimensional structure of an invertebrate rhodopsin and basis for ordered alignment in the photoreceptor membrane 1 1Edited by D. Rees

2001 • 74 citations

Structure and function in rhodopsin: Further elucidation of the role of the intradiscal cysteines, Cys-110, -185, and -187, in rhodopsin folding and function

1999 • 72 citations

Diffusible Ligand All-trans-retinal Activates Opsin via a Palmitoylation-dependent Mechanism

2000 • 71 citations

Light-induced exposure of the cytoplasmic end of transmembrane helix seven in rhodopsin

1998 • 67 citations

Highly Selective Separation of Rhodopsin from Bovine Rod Outer Segment Membranes Using Combination of Divalent Cation and Alkyl(thio)glucoside

1998 • 67 citations

Structure and function in rhodopsin. Separation and characterization of the correctly folded and misfolded opsins produced on expression of an opsin mutant gene containing only the native intradiscal cysteine codons

1995 • 62 citations

Rhodopsin Kinase Autophosphorylation

1995 • 61 citations

Engineering a Functional Blue-Wavelength-Shifted Rhodopsin Mutant

2001 • 61 citations

Rhodopsin analogues from highly hindered 7-cis isomers of retinal

1976 • 60 citations

The Molecular Origin of the Inhibition of Transducin Activation in Rhodopsin Lacking the 9-Methyl Group of the Retinal Chromophore: A UV−Vis and FTIR Spectroscopic Study

2000 • 57 citations

Effects of Carboxy-Terminal Truncation on the Stability and G Protein-Coupling Activity of Bovine Rhodopsin

1994 • 56 citations

In the eye of the beholder: Visual pigments and inherited variation in human vision

1994 • 53 citations

[42] Spectral sensitivities of human cone visual pigments determined in vivo and in vitro

2000 • 52 citations

Stereoisomeric Specificity of the Retinoid Cycle in the Vertebrate Retina

2000 • 51 citations

Signaling States of Rhodopsin

2001 • 51 citations

Palmitoylation of rhodopsin with S-protein acyltransferase: enzyme catalyzed reaction versus autocatalytic acylation

1998 • 51 citations

Photoregeneration of Bovine Rhodopsin from Its Signaling State

1995 • 47 citations

Matrix-assisted laser desorption mass spectrometry of rhodopsin and bacteriorhodopsin

1992 • 46 citations

The Visual Pigments of Geckos and other Vertebrates: An Essay in Comparative Biology

1977 • 45 citations

Mechanism of Rhodopsin Activation as Examined with Ring-constrained Retinal Analogs and the Crystal Structure of the Ground State Protein

2001 • 43 citations

Photochemical studies of 7-cis-rhodopsin at low temperatures. Nature and properties of the bathointermediate

1980 • 42 citations

Light-Induced Conformational Changes of Rhodopsin Probed by Fluorescent Alexa594 Immobilized on the Cytoplasmic Surface

2000 • 42 citations

Occupancy of the Chromophore Binding Site of Opsin Activates Visual Transduction in Rod Photoreceptors

1999 • 42 citations

Photoactivation of Rhodopsin Causes an Increased Hydrogen-Deuterium Exchange of Buried Peptide Groups

1998 • 41 citations

Proton Transfer Reactions Linked to Rhodopsin Activation

1998 • 39 citations

Functionally Discrete Mimics of Light-activated Rhodopsin Identified through Expression of Soluble Cytoplasmic Domains

2000 • 37 citations

Structure and function in rhodopsin: expression of functional mammalian opsin in Saccharomyces cerevisiae.

1996 • 36 citations

Ultraviolet Resonance Raman Examination of the Light-Induced Protein Structural Changes in Rhodopsin Activation

1997 • 34 citations

Opsin Expression in the Rat Retina Is Developmentally Regulated by Transcriptional Activation

1988 • 33 citations

Dominant-negative activity of an alpha1B-adrenergic receptor signal-inactivating point mutation

2000 • 32 citations

Spectroscopic study of the batho-to-lumi transition during the photobleaching of rhodopsin using ring-modified retinal analogs

1991 • 31 citations

A novel form of rhodopsin kinase from chicken retina and pineal gland¹

1999 • 30 citations

[22] Purification of rhodopsin on hydroxyapatite columns, detergent exchange, and recombination with phospholipids

1982 • 29 citations

[7] Preparation and analysis of two-dimensional crystals of rhodopsin

2000 • 23 citations

Molecular Biology of Light Transduction by the Mammalian Photoreceptor, Rhodopsin

2000 • 21 citations

Differences in the photobleaching process between 7-cis- and 11-cis-rhodopsins: a unique interaction change between the chromophore and the protein during the lumi-meta I transition

1991 • 19 citations

X-ray diffraction of heavy-atom labelled two-dimensional crystals of rhodopsin identifies the position of cysteine 140 in helix 3 and cysteine 316 in helix 8

2002 • 18 citations

[16] Synthetic retinals: Convenient probes of rhodopsin and visual transduction process

2000 • 17 citations

Rhodopsin and its kinase

2002 • 14 citations

[2] Baculovirus expression system for expression and characterization of functional recombinant visual pigments

2000 • 14 citations

Oxidation states of four sulfurs of rhodopsin before and after bleaching

1976 • 13 citations

Folding and Assembly in Rhodopsin

1999 • 12 citations

Molecular Isomers in Vision

1967 • 11 citations

[32] Structural analysis of carbohydrate moiety of bovine rhodopsin

1982 • 8 citations

[1] Heterologous expression of bovine opsin in Pichia pastoris

2000 • 7 citations

Highly Selective Separation of Rhodopsin from Bovine Rod Outer Segment Membranes Using Combination of Divalent Cation and Alkyl(thio)glucoside

1998 • 6 citations