Age-related epigenetic changes and the immune system

Translating the Histone Code

2001 • 9,488 citations

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

2003 • 6,017 citations

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

1999 • 5,748 citations

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

1999 • 4,776 citations

RNA interference

2002 • 3,369 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

The Role of DNA Methylation in Mammalian Epigenetics

2001 • 1,956 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

Chromatin modification and epigenetic reprogramming in mammalian development

2002 • 1,870 citations

Epigenetics: Regulation Through Repression

1999 • 1,215 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

2001 • 997 citations

The formation of skeletal muscle: from somite to limb

2003 • 859 citations

Cancer/testis antigens: an expanding family of targets for cancer immunotherapy

2002 • 851 citations

The many faces of histone lysine methylation

2002 • 819 citations

The aging of the immune system

2009 • 810 citations

DNA Methylation Decreases in Aging But Not in Immortal Cells

1983 • 635 citations

Aging and DNA methylation in colorectal mucosa and cancer.

1998 • 620 citations

DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter

1999 • 589 citations

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

1996 • 552 citations

Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements

2002 • 550 citations

Genomic 5-methyldeoxycytidine decreases with age.

1987 • 504 citations

Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system

1999 • 483 citations

Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.

1999 • 475 citations

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

2003 • 458 citations

CpG islands and genes

1995 • 449 citations

Gametic Imprinting in Mammals

1995 • 444 citations

Antigen-processing machinery breakdown and tumor growth

2000 • 444 citations

Role for DNA methylation in the control of cell type–specific maspin expression

2002 • 440 citations

Genetics and the Specificity of the Aging Process

2003 • 439 citations

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene

2003 • 420 citations

Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies.

1997 • 420 citations

Changes in DNA Methylation in Neoplasia: Pathophysiology and Therapeutic Implications

2001 • 414 citations

T cells and aging january 2002 update

2002 • 368 citations

Investigating stem cells in human colon by using methylation patterns

2001 • 356 citations

Creation of genomic methylation patterns

1996 • 313 citations

CpG-Island Methylation in Aging and Cancer

2000 • 302 citations

Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus

2002 • 286 citations

Expression of various genes is controlled by DNA methylation during mammalian development

2003 • 282 citations

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis.

1996 • 254 citations

The aging of the immune system

2002 • 238 citations

Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development.

2001 • 236 citations

Role of DNA Methylation in the Regulation of Cell Function: Autoimmunity, Aging and Cancer

2002 • 203 citations

Aging, DNA methylation and cancer

1999 • 188 citations

DNA methylation in aging of mice

1987 • 157 citations

Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer.

1994 • 147 citations

Epigenetic Variation and Human Disease

2002 • 126 citations

Model Organisms as a Guide to Mammalian Aging

2002 • 126 citations

The Epigenetics of Colorectal Cancer

2000 • 118 citations

Age-dependent DNA methylation changes in the ITGAL (CD11a) promoter

2002 • 116 citations

Epigenetic regulation of an IAP retrotransposon in the aging mouse: progressive demethylation and de-silencing of the element by its repetitive induction

2002 • 110 citations

Regulation of lifespan by histone deacetylase

2002 • 103 citations

p14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53

2003 • 97 citations

Cell division is required for de novo methylation of CpG islands in bladder cancer cells.

2002 • 97 citations

Quantitative changes in T cell DNA methylation occur during differentiation and ageing

1990 • 91 citations

The establishment and maintenance of DNA methylation patterns in mouse somatic cells

1999 • 78 citations

Impacts of transcriptional regulation on aging and senescence

2002 • 73 citations

Role of DNA methylation in the regulation of cell function

1999 • 73 citations

Decreased methylation of the major mouse long interspersed repeated DNA during aging and in myeloma cells

1986 • 71 citations

Epigenetic Gene Inactivation Induced by a Cis-acting Methylation Center

1995 • 71 citations

Messenger RNA levels and methlation patterns of GAPDH and β-actin genes in rat liver, spleen and brain in relation to aging

1990 • 67 citations

Infrequent occurrence of age-dependent changes in CpG island methylation as detected by restriction landmark genome scanning

2002 • 50 citations

Epigenetic regulation of gene expression

2003 • 41 citations

Methylation of the c-myc gene changes during aging process of mice

1986 • 36 citations

Endogenous virus genomes become hypomethylated tissue—Specifically during aging process of C57BL mice

1989 • 33 citations

Demethylation of satellite I DNA during senescence of bovine adrenocortical cells in culture

1992 • 33 citations

DNA Methylation in Aging and Cancer

1989 • 29 citations

Hypermethylation of CpG islands in the mouse asparagine synthetase gene: relationship to asparaginase sensitivity in lymphoma cells. Partial methylation in normal cells

2001 • 25 citations

Biology of the X chromosome

2001 • 23 citations

Hemoglobin switching and modulation: genes, cells, and signals

2002 • 11 citations

[Tissue-specific decrease and change in the character of DNA methylation in cattle with aging].

1978 • 11 citations

Deleted Work

1955 • 0 citations