The establishment and maintenance of DNA methylation patterns in mouse somatic cells

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1992 • 1,027 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

1996 • 784 citations

Spl elements protect a CpG island from de novo methylation

1994 • 713 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

A mammalian protein with specific demethylase activity for mCpG DNA

1999 • 624 citations

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.

1994 • 597 citations

Trinucleotide repeats that expand in human disease form hairpin structures in vitro

1995 • 559 citations

Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

1992 • 533 citations

Transcription Factor Sp1 Is Essential for Early Embryonic Development but Dispensable for Cell Growth and Differentiation

1997 • 524 citations

X-CHROMOSOME INACTIVATION IN MAMMALS

1997 • 524 citations

CpG islands and genes

1995 • 449 citations

Chromosome methylation patterns during mammalian preimplantation development

1998 • 427 citations

Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells

1998 • 408 citations

Cytosine methylation and mammalian development

1999 • 384 citations

DNA (cytosine-5)-methyltransferases in mouse cells and tissues. studies with a mechanism-based probe

1997 • 353 citations

Sex-specific exons control DNA methyltransferase in mammalian germ cells

1998 • 332 citations

Mapping Patterns of CpG Island Methylation in Normal and Neoplastic Cells Implicates Both Upstream and Downstream Regions inde Novo Methylation

1997 • 323 citations

DNA Methylation: Molecular Biology and Biological Significance

1993 • 306 citations

DNA methylation in early development

1995 • 283 citations

Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse.

1987 • 278 citations

A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast

1998 • 274 citations

Hairpins are formed by the single DNA strands of the fragile X triplet repeats: structure and biological implications.

1995 • 220 citations

Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity

1985 • 199 citations

DNA methylation: Molecular biology and biological significance

1993 • 193 citations

DNA Demethylation In Vitro: Involvement of RNA

1996 • 188 citations

Distinct Methylation of the Interferon γ (IFN-γ) and Interleukin 3 (IL-3) Genes in Newly Activated Primary CD8+ T Lymphocytes: Regional IFN-γ Promoter Demethylation and mRNA Expression Are Heritable in CD44highCD8+ T Cells

1998 • 171 citations

Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine.

1993 • 160 citations

Mechanisms of DNA Demethylation in Chicken Embryos

1995 • 129 citations

Formation of methylation patterns in the mammalian genome

1997 • 114 citations

Alu RNA secondary structure consists of two independent 7 SL RNA-like folding units

1991 • 114 citations

Genomic sequencing reveals a 5-methylcytosine-free domain in active promoters and the spreading of preimposed methylation patterns.

1989 • 109 citations

An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA

1998 • 102 citations

Recognition of unusual DNA structures by human DNA(cytosine-5)methyltransferase

1991 • 100 citations

CpG islands: features and distribution in the genomes of vertebrates

1991 • 98 citations

The primary function of a redundant Sp1 binding site in the mouse aprt gene promoter is to block epigenetic gene inactivation

1998 • 82 citations

A cis-acting element accounts for a conserved methylation pattern upstream of the mouse adenine phosphoribosyltransferase gene.

1993 • 78 citations

DNA methylation and embryogenesis

1993 • 77 citations

A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells.

1990 • 76 citations

Epigenetic Gene Inactivation Induced by a Cis-acting Methylation Center

1995 • 71 citations

Enhancement of reporter gene de novo methylation by DNA fragments from the alpha-fetoprotein control region.

1994 • 69 citations

Demethylation of DNA by purified chick embryo 5-methylcytosine-DNA glycosylase requires both protein and RNA

1997 • 60 citations

Control of methylation spreading in synthetic DNA sequences by the murine DNA methyltransferase

1997 • 59 citations

Regulation and Function of DNA Methylation in Vertebrates

1998 • 54 citations

DNA methylation in genomic imprinting

1997 • 54 citations

A partial methylation profile for a CpG site is stably maintained in mammalian tissues and cultured cell lines

1989 • 44 citations

Activation of the lac Repressor in the Transgenic Mouse

1997 • 40 citations

Sequence-specific methylation of the mouseH19 gene in embryonic cells deficient in theDnmt-1 gene

1998 • 38 citations

Identification of DNA sequences required for mouse APRT gene expression

1988 • 31 citations

Spreading of methylation along DNA

1996 • 31 citations

Region- and cell type-specific de novo DNA methylation in cultured mammalian cells

1991 • 26 citations

cis-Acting Signal for Inheritance of Imprinted DNA Methylation Patterns in the Preimplantation Mouse Embryo

1998 • 23 citations

Influence of Pre-existing Methylation on the de Novo Activity of Eukaryotic DNA Methyltransferase

1998 • 21 citations

At least two distinct epigenetic mechanisms are correlated with high-frequency ?switching? for aprt phenotypic expression in mouse embryonal carcinoma stem cells

1992 • 20 citations

Mechanism of active DNA demethylation during embryonic development and cellular differentiation in vertebrates

1995 • 18 citations

Spontaneous and ionizing radiation induced mutations involve large events when selecting for loss of an autosomal locus

1995 • 17 citations

Hemidemethylation is sufficient for chromatin relaxation and transcriptional activation of methylatedaprt gene in mouse P19 embryonal carcinoma cell line

1993 • 12 citations

Variability in allelic DNA methylation in spermatozoa

1994 • 3 citations