DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

1992 • 3,099 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

1997 • 1,235 citations

Number of CpG islands and genes in human and mouse.

1993 • 986 citations

The essentials of DNA methylation

1992 • 960 citations

CpG islands as gene markers in the human genome

1992 • 908 citations

The 5-methylcytosine content of DNA from human tumors

1983 • 835 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

T cell defined tumor antigens

1997 • 641 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Structure, chromosomal localization, and expression of 12 genes of the MAGE family

1994 • 595 citations

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

1995 • 591 citations

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

1996 • 552 citations

Gene number, noise reduction and biological complexity

1995 • 462 citations

CpG islands and genes

1995 • 449 citations

5-Methylcytosine, Gene Regulation, and Cancer

1983 • 425 citations

Cytosine methylation and mammalian development

1999 • 384 citations

DNA methylation directs a time-dependent repression of transcription initiation

1997 • 372 citations

X-chromosome inactivation and cell memory

1992 • 329 citations

Role of DNA methylation in the regulation of transcription

1994 • 318 citations

Immunogenic (tum-) variants of mouse tumor P815: cloning of the gene of tum- antigen P91A and identification of the tum- mutation.

1988 • 293 citations

Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.

1994 • 292 citations

In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells.

1982 • 271 citations

LAGE-1, a new gene with tumor specificity

1998 • 268 citations

Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability.

1990 • 264 citations

Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis.

1995 • 227 citations

A role for nuclear NF–κB in B–cell–specific demethylation of the Igκ locus

1996 • 216 citations

Transfection and expression of a gene coding for a human melanoma antigen recognized by autologous cytolytic T lymphocytes

1992 • 198 citations

Identification of a new MAGE gene with tumor-specific expression by representational difference analysis.

1998 • 184 citations

Asymmetric Methylation in the Hypermethylated CpG Promoter Region of the Human L1 Retrotransposon

1997 • 169 citations

Characterization of the GAGE genes that are expressed in various human cancers and in normal testis.

1999 • 167 citations

Sex difference in methylation of single-copy genes in human meiotic germ cells: Implications for X chromosome inactivation, parental imprinting, and origin of CpG mutations

1990 • 161 citations

Differential transcription of Pgk genes during spermatogenesis in the mouse

1992 • 154 citations

Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine.

1982 • 149 citations

Sequence and expression pattern of the human MAGE2 gene

1994 • 144 citations

Two Members of the HumanMAGEBGene Family Located in Xp21.3 Are Expressed in Tumors of Various Histological Origins

1997 • 139 citations

Developmental differences in methylation of human Alu repeats.

1993 • 129 citations

Isolation and characterization of a MAGE gene family in the Xp21.3 region.

1995 • 106 citations

Extent of DNA methylation in human tumor cells.

1983 • 97 citations

Analysis of CpG methylation and genomic footprinting at the tyrosine aminotransferase gene: DNA methylation alone is not sufficient to prevent protein binding in vivo.

1991 • 95 citations

Involvement of two Ets binding sites in the transcriptional activation of the MAGE1 gene

1995 • 93 citations

DNA hypomethylation and germ cell-specific expression of testis-specific H2B histone gene.

1991 • 62 citations

Melanosomal proteins as melanoma-specific immune targets

1997 • 58 citations

DNA methylation changes during mouse spermatogenesis

1994 • 49 citations

MAGE-1 expression threshold for the lysis of melanoma cell lines by a specific cytotoxic T lymphocyte.

1997 • 48 citations

CpG Island Promoter Region Methylation Patterns of the Inactive-X-Chromosome Hypoxanthine Phosphoribosyltransferase (Hprt) Gene

1994 • 40 citations

Methylation and expression of the Myo D1 determination gene

1990 • 31 citations

The CpG‐rich promoter of human LDH‐C is differentially methylated in expressing and nonexpressing tissues

1995 • 21 citations

Identification of Human Testis-Specific Transcripts and Analysis of Their Expression in Tumor Cells

1997 • 20 citations

Chicken spermatogenesis is accompanied by a genomic‐wide loss of DNA methylation

1989 • 14 citations

Researches on Animals Containing Chlorophyll

1882 • 3 citations