Genomic 5-methyldeoxycytidine decreases with age.

DNA Methylation and Gene Function

1980 • 2,069 citations

Developmental potential and dynamic behavior of hematopoietic stem cells

1986 • 888 citations

Handbook of the Biology of Aging

1978 • 871 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

DNA Methylation Decreases in Aging But Not in Immortal Cells

1983 • 635 citations

Viral oncogenes

1985 • 605 citations

32P-labeling test for DNA damage.

1981 • 531 citations

5-Methylcytosine, Gene Regulation, and Cancer

1983 • 425 citations

A serum-free method for culturing normal human bronchial epithelial cells at clonal density

1985 • 344 citations

A new theory of carcinogenesis

1979 • 201 citations

Molecular Biology of Aging: Gene Stability and Gene Expression

1986 • 163 citations

Age- and tissue-related DNA modifications in untreated rats: detection by ³²P-postlabeling assay and possible significance for spontaneous tumor induction and aging

1986 • 152 citations

Methylation of reiterated sequences in mammalian DNAs Effects of the tissue type, age, malignancy and hormonal induction

1981 • 140 citations

The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation

1987 • 119 citations

Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA

1982 • 117 citations

Effects of 5-azacytidine and its 2′-deoxyderivative on cell differentiation and DNA methylation

1985 • 116 citations

Methylation, expression and chromosomal position of genes in mammals

1984 • 100 citations

Loss of reiterated DNA sequences during serial passage of human diploid fibroblasts

1980 • 96 citations

Age-dependent relaxation of gene repression: Increase of endogenous murine leukemia virus-related and globin-related RNA in brain and liver of mice

1978 • 96 citations

Presence of a DNA demethylating activity in the nucleus of murine erythroleukemic cells.

1982 • 88 citations

On a possible epigenetic mechanism(s) of tumor cell heterogeneity

1983 • 87 citations

Molecular biology of aging

1985 • 73 citations

Methylation and rearrangement of mouse intracisternal a particle genes in development, aging, and myeloma.

1983 • 65 citations

Carcinogenesis and Aging

1983 • 51 citations

DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11.

1984 • 45 citations

Genomic 5-methylcytosine determination by 32P-postlabeling analysis

1986 • 44 citations

Chemical carcinogen-mediated decreases in DNA 5-methylcytosine content of BALB/3T3 cells

1984 • 42 citations

Chemical carcinogen-induced decreases in genomic 5-methyldeoxycytidine content of normal human bronchial epithelial cells.

1987 • 40 citations

Percent satellite DNA as a function of tissue and age of mice

1976 • 30 citations

Regulation of endogenous murine leukemia virus-related nuclear and cytoplasmic RNA complexity in C57BL/6J mice of increasing age.

1980 • 29 citations

Induction of Hepatitis B Virus Core Gene in Human Cells by Cytosine Demethylation in the Promoter

1985 • 28 citations

Changes in de novo DNA (cytosine-5-)-methyltransferase activity in oncogenically susceptible rat target tissues induced by N-methyl-N-nitrosourea.

1986 • 13 citations