Evidence of canonical somatic hypermutation in hairy cell leukemia

Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936

2003 • 2,949 citations

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

1999 • 2,674 citations

Molecular Mechanisms of Antibody Somatic Hypermutation

2007 • 1,018 citations

Leukemic Reticuloendotheliosis

1958 • 542 citations

Evolution of Autoantibody Responses via Somatic Hypermutation Outside of Germinal Centers

2002 • 522 citations

Efficacy of the Anti-CD22 Recombinant Immunotoxin BL22 in Chemotherapy-Resistant Hairy-Cell Leukemia

2001 • 514 citations

The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

1994 • 415 citations

CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans

2001 • 405 citations

Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis

2007 • 328 citations

Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia

2004 • 280 citations

Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

2004 • 258 citations

Somatic hypermutation

1995 • 248 citations

Phase II Trial of Recombinant Immunotoxin RFB4(dsFv)-PE38 (BL22) in Patients With Hairy Cell Leukemia

2009 • 209 citations

The Inference of Antigen Selection on Ig Genes

2000 • 186 citations

Evolutionary nucleotide replacements in DNA

1979 • 169 citations

VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapy

2009 • 148 citations

Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands

1998 • 128 citations

Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single-agent cladribine and with more aggressive behavior

2009 • 122 citations

Monitoring and interpreting the intrinsic features of somatic hypermutation

1998 • 122 citations

Commentary on and reprint of Bouroncle BA, Wiseman BK, Doan CA, Leukemic reticuloendotheliosis, in Blood (1958) 13:609–630

2000 • 109 citations

Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human V rearrangements

1998 • 107 citations

Evidence for Involvement of a Hydrophobic Patch in Framework Region 1 of Human V4-34-Encoded Igs in Recognition of the Red Blood Cell I Antigen

2002 • 101 citations

Relevance of the immunoglobulin VH somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens

2008 • 93 citations

Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing

2001 • 88 citations

The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process

2003 • 86 citations

The normal IGHV1-69–derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL

2009 • 85 citations

Somatic mutation analysis of IgH variable regions reveals that tumor cells of most parafollicular (monocytoid) B-cell lymphoma, splenic marginal zone B-cell lymphoma, and some hairy cell leukemia are composed of memory B lymphocytes

1999 • 69 citations

Variables affecting the quantitation of CD22 in neoplastic B cells

2010 • 60 citations

Immunoglobulin gene segment usage, location and immunogenicity in mutated and unmutated chronic lymphocytic leukaemia

2005 • 58 citations

Definition of progression risk based on combinations of cellular and molecular markers in patients with Binet stage A chronic lymphocytic leukaemia

2009 • 56 citations

VH gene expression in hairy cell leukaemia

1998 • 55 citations

Heterogeneous somatic hypermutation status confounds the cell of origin in hairy cell leukemia

2004 • 48 citations

Somatic hypermutation and VH gene usage in hairy cell leukaemia

2006 • 43 citations

High frequency of somatic mutations in the VH genes expressed in prolymphocytic leukemia

1996 • 40 citations

VH gene analysis of hairy cell leukemia reveals a homogeneous mutation status and suggests its marginal zone B-cell origin

2004 • 40 citations

Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia

2008 • 36 citations

Bouroncle BA, Wiseman BK, Doan CA. Leukemic reticuloendotheliosis. Blood. 1958;13(7):609-630.

2016 • 34 citations

Transcription-Dependent Somatic Hypermutation Occurs at Similar Levels on Functional and Nonfunctional Rearranged IgH Alleles

2004 • 25 citations

The immunoglobulin genes: Structure and specificity in chronic lymphocytic leukemia

2007 • 14 citations

Somatic Mutation of Human Immunoglobulin V Genes: Bias, Rate, and Regulation

1995 • 12 citations

Molecular Characterization of Complete and Incomplete Immunoglobulin Heavy Chain Gene Rearrangements in Hairy Cell Leukemia

2007 • 10 citations

Lack of allelic exclusion by secondary rearrangements of tumour B‐cell receptor light chains in hairy cell leukaemia

2010 • 8 citations

V_H Gene Repertoire of Mantle Cell Lymphomas

1995 • 7 citations

Hairy Cell Leukemia

2009 • 6 citations

IGHV Unmutated Status Influences Outcome More Than IGHV1-69 Gene Usage Per Se in Patients With Chronic Lymphocytic Leukemia

2009 • 5 citations

Cited By (0)

No citing papers found in database