The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process

Sequences of proteins of immunological interest

1984 • 3,427 citations

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

1999 • 2,674 citations

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia

1999 • 2,557 citations

Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia

2001 • 1,110 citations

Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells

2001 • 934 citations

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

1998 • 899 citations

Evolution of Autoantibody Responses via Somatic Hypermutation Outside of Germinal Centers

2002 • 522 citations

Genetic and Structural Evidence for Antigen Selection of Anti-DNA Antibodies

1994 • 464 citations

The mutation rate and cancer

1996 • 459 citations

Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction.

1995 • 434 citations

CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans

2001 • 405 citations

The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

1994 • 390 citations

B Cell Chronic Lymphocytic Leukemia: Lessons Learned from Studies of the B Cell Antigen Receptor

2003 • 377 citations

Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.

1997 • 373 citations

B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes

2002 • 358 citations

Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vλ2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope

2003 • 318 citations

Structure and Function of Natural Antibodies

1996 • 286 citations

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

1993 • 271 citations

Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia

2004 • 240 citations

Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features.

1997 • 230 citations

SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES

1996 • 192 citations

Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.

1997 • 180 citations

Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells.

1996 • 175 citations

The Generation of Diversity in Phosphorylcholine-Binding Antibodies

1984 • 153 citations

Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone

2003 • 150 citations

High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia

2003 • 150 citations

Monitoring and interpreting the intrinsic features of somatic hypermutation

1998 • 122 citations

Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation

2003 • 119 citations

Chronic Lymphoid Leukemias

2001 • 112 citations

The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially

2001 • 106 citations

Heterogeneity of Tonsillar Subepithelial B Lymphocytes, the Splenic Marginal Zone Equivalents

2000 • 102 citations

Chronic Lymphocytic Leukemia B Cells Can Undergo Somatic Hypermutation and Intraclonal Immunoglobulin VHDJH Gene Diversification

2002 • 98 citations

Single germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate.

1987 • 74 citations

Staphylococcal enterotoxin D functions as a human B cell superantigen by rescuing VH4-expressing B cells from apoptosis.

1996 • 64 citations

Evolution of Ig DNA Sequence to Target Specific Base Positions Within Codons for Somatic Hypermutation

2002 • 60 citations

Characteristics of Sequences Around Individual Nucleotide Substitutions in IgVH Genes Suggest Different GC and AT Mutators

1999 • 57 citations

A Hypermutable Insert in an Immunoglobulin Transgene Contains Hotspots of Somatic Mutation and Sequences Predicting Highly Stable Structures in the RNA Transcript

1998 • 56 citations

Somatic mutation of bcl-6 genes can occur in the absence of VH mutations in chronic lymphocytic leukemia

2000 • 50 citations

Base-Specific Sequences That Bias Somatic Hypermutation Deduced by Analysis of Out-of-Frame Human IgVH Genes

1998 • 46 citations

Staphylococcal Enterotoxin A Induces Survival of VH3-Expressing Human B Cells by Binding to the VH Region with Low Affinity

1998 • 45 citations

VH families in the antibody response to p-azophenylarsonate: correlation between serology and amino acid sequence.

1982 • 44 citations

Analysis of VH gene expression in CD5+ and CD5- B-cell chronic lymphocytic leukemia

1995 • 37 citations

Two Human Neonatal IgM Antibodies Encoded by Different Variable-Region Genes Bind the Same Linear Peptide: Evidence for a Stereotyped Repertoire of Epitope Recognition

1999 • 34 citations

Antibodies to β(1,6)‐D‐Galactan: Proteins, Idiotypes and Genes

1988 • 11 citations