Immunoglobulin gene segment usage, location and immunogenicity in mutated and unmutated chronic lymphocytic leukaemia

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Individual Comparisons by Ranking Methods

1945 • 12,649 citations

Evaluation of survival data and two new rank order statistics arising in its consideration.

1966 • 7,595 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Analysis of Binary Data

2008 • 2,760 citations

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

1999 • 2,674 citations

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia

1999 • 2,557 citations

National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment

1996 • 1,906 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia

2001 • 1,110 citations

Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells

2001 • 934 citations

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

1998 • 899 citations

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

1994 • 838 citations

ProPred: prediction of HLA-DR binding sites

2001 • 823 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

1995 • 703 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

Hematology: Basic Principles and Practice

1995 • 526 citations

Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia.

1982 • 478 citations

The human immunoglobulin VH repertoire

1995 • 469 citations

Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction.

1995 • 434 citations

Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia

2004 • 433 citations

The Complete Nucleotide Sequence of the Human Immunoglobulin Heavy Chain Variable Region Locus

1998 • 401 citations

Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.

1997 • 373 citations

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia

2003 • 330 citations

Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vλ2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope

2003 • 318 citations

Antigen-driven B cell differentiation in vivo.

1993 • 308 citations

Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia

2004 • 280 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

2004 • 258 citations

Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia

2004 • 240 citations

Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features.

1997 • 230 citations

Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation

1996 • 225 citations

Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene

2004 • 209 citations

The Inference of Antigen Selection on Ig Genes

2000 • 186 citations

Immunoglobulin framework-derived peptides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies

2000 • 183 citations

Evolutionary nucleotide replacements in DNA

1979 • 169 citations

An improved method for detection of B-lymphoid clonality by polymerase chain reaction.

1991 • 144 citations

Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations

2003 • 142 citations

Evidence for somatic selection of natural autoantibodies.

1992 • 126 citations

High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy

2004 • 126 citations

Lack of Allelic Exclusion in B Cell Chronic Lymphocytic Leukemia

1997 • 108 citations

High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy

2004 • 107 citations

The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process

2003 • 86 citations

Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire

2003 • 83 citations

Third complementarity‐determining region of mutated V_H immunoglobulin genes contains shorter V, D, J, P, and N components than non‐mutated genes

2001 • 79 citations

VH gene usage is multiple myeloma: complete absence of the VH4.21 (VH4- 34) gene

1996 • 79 citations

Normal B Cells Express51p1-Encoded Ig Heavy Chains That Are Distinct From Those Expressed by Chronic Lymphocytic Leukemia B Cells

2001 • 69 citations

Analysis of IgV_H gene mutations in B cell chronic lymphocytic leukaemia according to antigen‐driven selection identifies subgroups with different prognosis and usage of the canonical somatic hypermutation machinery

2004 • 63 citations

Induction of cytotoxic T-cell responses against immunoglobulin V region–derived peptides modified at human leukocyte antigen–A2 binding residues

2001 • 63 citations

Chronic Lymphocytic Leukemia

1984 • 54 citations

Utilization of Ig heavy chain variable, diversity, and joining gene segments in children with B-lineage acute lymphoblastic leukemia: implications for the mechanisms of VDJ recombination and for pathogenesis

2004 • 47 citations

Preferential rearrangement of developmentally regulated immunoglobulin VH1 genes in human B-lineage leukaemias.

1991 • 46 citations

V(H) gene usage differs in germline and mutated B-cell chronic lymphocytic leukemia.

2003 • 39 citations

Immunoglobulin heavy-chain gene rearrangement in adult acute lymphoblastic leukemia reveals preferential usage of JH-proximal variable gene segments

2001 • 31 citations

Antigenicity and immunogenicity of peptide analogues of a low affinity peptide of the human telomerase reverse transcriptase tumor antigen

2004 • 24 citations

Germ line tumor-associated immunoglobulin VH region peptides provoke a tumor-specific immune response without altering the response potential of normal B cells

2004 • 11 citations

Cytotoxic T Cell Reponses Against Immunoglobulin in Malignant and Normal B Cells: Implications for Tumor Immunity and Autoimmunity

2003 • 11 citations