VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapy

Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936

2003 • 2,949 citations

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

1999 • 2,674 citations

IMGT(R), the international ImMunoGeneTics information system(R)

2008 • 1,067 citations

Efficacy of the Anti-CD22 Recombinant Immunotoxin BL22 in Chemotherapy-Resistant Hairy-Cell Leukemia

2001 • 514 citations

Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.

1997 • 373 citations

Long-Term Follow-Up of Patients With Hairy Cell Leukemia After Cladribine Treatment

1998 • 318 citations

B Cell Repertoire Diversity and Clonal Expansion in Multiple Sclerosis Brain Lesions

1999 • 292 citations

Extended Follow-Up of Patients With Hairy Cell Leukemia After Treatment With Cladribine

2003 • 273 citations

Randomized comparison of pentostatin versus interferon alfa-2a in previously untreated patients with hairy cell leukemia: an intergroup study.

1995 • 268 citations

Phase I Trial of Recombinant Immunotoxin RFB4(dsFv)-PE38 (BL22) in Patients With B-Cell Malignancies

2005 • 263 citations

Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria

2007 • 257 citations

Accumulation of Clonally Related B Lymphocytes in the Cerebrospinal Fluid of Multiple Sclerosis Patients

2000 • 247 citations

Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens

1991 • 216 citations

VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities.

1992 • 214 citations

Primary Central Nervous System Lymphomas Are Derived from Germinal-Center B Cells and Show a Preferential Usage of the V4–34 Gene Segment

1999 • 180 citations

VH4-34 encoded antibodies in systemic lupus erythematosus: a specific diagnostic marker that correlates with clinical disease characteristics.

1999 • 174 citations

A chronic lymphoproliferative disorder with distinctive features: a distinct variant of hairy-cell leukaemia

1980 • 165 citations

VH4-34 encoded antibody in systemic lupus erythematosus: effect of isotype.

2002 • 149 citations

A variant form of hairy cell leukemia resistant to alpha-interferon: clinical and phenotypic characteristics of 17 patients

1990 • 148 citations

The variant form of hairy-cell leukaemia

2003 • 147 citations

Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA): long-term follow-up of the Northwestern University experience

2005 • 139 citations

Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma

1995 • 129 citations

Eradication of minimal residual disease in hairy cell leukemia

2006 • 126 citations

Immunophenotypic Profile of Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia

2005 • 124 citations

Immunophenotypic Profile of Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia

2005 • 115 citations

Immunoglobulin V_H gene expression in human B cell lines and tumors: biased V_H gene expression in chronic lymphocytic leukemia

1989 • 112 citations

Long remissions in hairy cell leukemia with purine analogs

2005 • 110 citations

Long-term outcome with pentostatin treatment in hairy cell leukemia patients. A French retrospective study of 238 patients

2003 • 107 citations

Identification of normal B‐cell counterparts of neoplastic cells which secrete cold agglutinins of anti‐I and anti‐i specificity

1989 • 101 citations

Human antilipid A monoclonal antibodies bind to human B cells and the i antigen on cord red blood cells.

1993 • 91 citations

Evidence for the occurrence of O-glycosidically linked oligosaccharides of poly-N-acetyllactosamine type on the human leucocyte common antigen

1983 • 91 citations

Comparison of immunoglobulin G heavy-chain sequences in MS and SSPE brains reveals an antigen-driven response

2000 • 89 citations

Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing

2001 • 88 citations

Immunophenotyping and Differential Diagnosis of Hairy Cell Leukemia

2006 • 86 citations

High-frequency representation of a single VH gene in the expressed human B cell repertoire.

1993 • 83 citations

Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments

1994 • 81 citations

VH gene usage is multiple myeloma: complete absence of the VH4.21 (VH4- 34) gene

1996 • 79 citations

Hairy Cell Leukemia Variant

2005 • 76 citations

Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire.

1995 • 75 citations

Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas

2007 • 74 citations

Complete Remissions in Hairy Cell Leukemia with 2-Chlorodeoxyadenosine after Failure with 2-Deoxycoformycin

1993 • 70 citations

Somatic mutation analysis of IgH variable regions reveals that tumor cells of most parafollicular (monocytoid) B-cell lymphoma, splenic marginal zone B-cell lymphoma, and some hairy cell leukemia are composed of memory B lymphocytes

1999 • 69 citations

V gene usage by seven hybrids derived from CD5+ B-cell chronic lymphocytic leukemia and displaying autoantibody activity

1993 • 60 citations

VH gene expression in hairy cell leukaemia

1998 • 55 citations

The role of rituximab in combination with pentostatin or cladribine for the treatment of recurrent/refractory hairy cell leukemia

2007 • 53 citations

Rapid cytotoxicity of human B lymphocytes induced by VH4-34 (VH4.21) gene-encoded monoclonal antibodies

1996 • 50 citations

The Immunoglobulin G Heavy Chain Repertoire in Multiple Sclerosis Plaques Is Distinct from the Heavy Chain Repertoire in Peripheral Blood Lymphocytes

2001 • 49 citations

Massive abdominal lymphadenopathy in hairy cell leukaemia: a report of 12 cases

1992 • 48 citations

Heterogeneous somatic hypermutation status confounds the cell of origin in hairy cell leukemia

2004 • 48 citations

The Scripps Clinic experience with 2-chlorodeoxyadenosine in the treatment of hairy cell leukemia.

1994 • 46 citations

Treatment of Hairy Cell Leukemia-Variant with Cladribine

1999 • 45 citations

Somatic hypermutation and VH gene usage in hairy cell leukaemia

2006 • 43 citations

Results of a Salvage Regimen in Refractory or Relapsed Non-Hodgkin's Lymphoma

1994 • 41 citations

VH gene analysis of hairy cell leukemia reveals a homogeneous mutation status and suggests its marginal zone B-cell origin

2004 • 40 citations

Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia

2008 • 36 citations

2‐Chlorodeoxyadenosine in the treatment of hairy cell leukaemia: differences in response in patients with and without abdominal lymphadenopathy

1996 • 34 citations

Incidence and significance of abdominal lymphadenopathy in hairy cell leukaemia.

1994 • 32 citations

Successful treatment of hairy cell leukemia variant with rituximab

2005 • 32 citations

Hairy cell leukemia–variant treated with 2-Chlorodeoxyadenosine—a report of three cases

1997 • 30 citations

Rapid cytotoxicity of human B lymphocytes induced by VH4-34 (VH4.21) gene-encoded monoclonal antibodies, II

1997 • 30 citations

Molecular characteristics and gene segment usage in IGH gene rearrangements in multiple myeloma.

2005 • 29 citations

Immunoglobulin V_H4 gene usage in B lymphoid leukaemias

1993 • 27 citations

Prognosis of High Dose Chemotherapy/Autologous Bone Marrow Transplantation Candidates not Receiving This Treatment after Failure of Primary Therapy of Hodgkin's Disease

1994 • 27 citations

Anti‐B cell autoantibodies encoded by V_H 4–21 genes in human fetal spleen do not require in vivo somatic selection

1994 • 26 citations

Complete remission of hairy cell leukemia variant (HCL-v) complicated by red cell aplasia post treatment with rituximab.

2005 • 22 citations

Molecular characteristics and gene segment usage in IGH gene rearrangements in multiple myeloma.

2005 • 17 citations

Skewed Rearrangement of the VH4-21 Gene During Pre-B Acute Lymphoblastic Leukemia

1995 • 16 citations

Successful Induction of Long-Term Remission Using Rituximab in a Patient with Refractory Hairy Cell Leukemia-Japanese Variant

2004 • 15 citations

Reaction Patterns of TRAP and DBA.44 in Hairy Cell Leukemia, Hairy Cell Variant, and Nodal and Extranodal Marginal Zone B-cell Lymphomas

2008 • 11 citations

Molecular Characterization of Complete and Incomplete Immunoglobulin Heavy Chain Gene Rearrangements in Hairy Cell Leukemia

2007 • 10 citations

A VH4-34+ myeloma protein with weak autoreactivity

2007 • 10 citations

Hairy Cell Leukemia Variant

2004 • 9 citations

Clinical and molecular complete remission in a case of variant hairy cell leukemia treated with DHAP followed by high-dose chemotherapy plus rituximab.

2004 • 8 citations

Cytotoxicity of Murine B Lymphocytes Induced by Human VH4-34 (VH4.21) Gene-Encoded Monoclonal Antibodies

1997 • 7 citations

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