Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands

Somatic generation of antibody diversity

1983 • 3,275 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

Statistical Methods for the Analysis of Biomedical Data

1989 • 602 citations

Variability in the Lambda Light Chain Sequences of Mouse Antibody

1970 • 554 citations

Structural Insights into the Evolution of an Antibody Combining Site

1997 • 550 citations

Somatic hypermutagenesis in immunoglobulin genes

1992 • 458 citations

Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction.

1995 • 434 citations

Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription Initiation

1996 • 424 citations

Evolutionary and Somatic Selection of the Antibody Repertoire in the Mouse

1987 • 388 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.

1997 • 373 citations

Affinity maturation without germinal centres in lymphotoxin-α-deficient mice

1996 • 322 citations

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

1990 • 318 citations

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process

1995 • 318 citations

Life and Death in Germinal Centers (Redux)

1996 • 315 citations

Statistical Methods for the Analysis of Biomedical Data.

1988 • 302 citations

ACCESSIBILITY CONTROL OF ANTIGEN-RECEPTOR VARIABLE-REGION GENE ASSEMBLY: Role ofcis-Acting Elements

1996 • 295 citations

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

1993 • 283 citations

Somatic hypermutation

1995 • 248 citations

Targeting of non-lg sequences in place of the V segment by somatic hyper mutation

1995 • 223 citations

Discriminating intrinsic and actigen-selected mutational hotspots in immunoglobulin V genes

1993 • 222 citations

SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES

1996 • 192 citations

Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.

1997 • 180 citations

Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells.

1996 • 175 citations

Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts

1997 • 151 citations

The Transcriptional Promoter Regulates Hypermutation of the Antibody Heavy Chain Locus

1997 • 142 citations

Induction of Somatic Mutation in a Human B Cell Line In Vitro

1997 • 141 citations

Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts.

1997 • 137 citations

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3′ of C kappa and occurs on passenger transgenes.

1991 • 132 citations

Distribution of Mutations around Rearranged Heavy-Chain Antibody Variable-Region Genes

1990 • 129 citations

Somatic hypermutation: How many mechanisms diversify V region sequences?

1995 • 116 citations

Distribution of mutations around rearranged heavy-chain antibody variable-region genes.

1990 • 93 citations

An immunoglobulin mutator that targets G.C base pairs.

1996 • 76 citations

Somatic hypermutation in 5′ flanking regions of heavy chain antibody variable regions

1993 • 69 citations

Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.

1991 • 69 citations

Delineation of Selective Influences Shaping the Mutated Expressed Human Ig Heavy Chain Repertoire

1998 • 58 citations

The 5′ hypermutation boundary of x chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription

1997 • 48 citations

B Lymphocytes of Xeroderma Pigmentosum or Cockayne Syndrome Patients with Inherited Defects in Nucleotide Excision Repair Are Fully Capable of Somatic Hypermutation of Immunoglobulin Genes

1997 • 45 citations

Somatic Mutation: From the dark zone to the light

1994 • 45 citations

Comparable impact of mutational and selective influences in shaping the expressed repertoire of peripheral IgM+/CD5− and IgM+/CD5+ B cells

1998 • 37 citations

The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes

1997 • 27 citations

Characterization of thecis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches

1996 • 26 citations

Introduction: What mechanism(s) drive hypermutation?

1996 • 20 citations

The Promotion of V Region Hypermutation

1997 • 17 citations

A DNA repair abnormality specific for rearranged immunoglobulin variable genes in germinal center B cells

1996 • 7 citations