Somatic Mutation of Human Immunoglobulin V Genes: Bias, Rate, and Regulation

Germinal Centers

1994 • 1,680 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Intraclonal generation of antibody mutants in germinal centres

1991 • 1,083 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.

1993 • 367 citations

Immunodeficiency with hyper-IgM (HIM).

1992 • 318 citations

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

1990 • 318 citations

Origin of Antibody Variation

1966 • 314 citations

The Role of Somatic Hypermutation in the Generation of Antibody Diversity

1989 • 305 citations

Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae.

1982 • 303 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

1993 • 271 citations

CD40 ligand and its role in X-linked hyper-IgM syndrome

1993 • 257 citations

Clusters of point mutations are found exclusively around rearranged antibody variable genes.

1983 • 233 citations

B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells.

1993 • 158 citations

Patterns of Somatic Mutations in Immunoglobulin Variable Genes

1987 • 158 citations

The Development of B Cells and the B‐Cell Repertoire in the Microenvironment of the Germinal Center

1992 • 148 citations

Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell‐dependent antigen

1992 • 119 citations

Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.

1989 • 103 citations

Isoelectric focusing of human antibody to the Haemophilus influenzae b capsular polysaccharide: restricted and identical spectrotypes in adults.

1985 • 74 citations

Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. II. IgG antibodies contain VH genes from a single VH family and VL genes from at least four VL families.

1989 • 69 citations

Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.

1991 • 69 citations

Mutation and selection during the secondary response to 2-phenyloxazolone.

1991 • 68 citations

An idiotypic marker associated with a germ-line encoded kappa light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharide.

1991 • 65 citations

V gene rearrangement is required to fully activate the hypermutation mechanism in B cells.

1989 • 64 citations

V_H gene usage in humans: biased usage of the V_H6 gene in immature B lymphoid cells

1991 • 60 citations

Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen.

1992 • 58 citations

Somatic mutation of human immunoglobulin V genes in the X-linked HyperIgM syndrome.

1995 • 56 citations

Somatic mutation in constant regions of mouse lambda 1 light chains.

1991 • 55 citations

The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?

1990 • 54 citations

The molecular basis for T cell help in humoral immunity: CD40 and its ligand, gp39

1993 • 41 citations

Comparison of somatic mutation frequency among immunoglobulin genes.

1994 • 40 citations

Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes.

1991 • 39 citations

Pecularities of immunoglobulin gene structures as a basis for somatic mutation emergence

1987 • 35 citations

Bias in somatic hypermutation of human V_H genes

1994 • 35 citations

Conservation of the most JH proximal Ig VH gene segment (VHVI) throughout primate evolution.

1991 • 34 citations

The Repertoire of Human Antibody to the Haemophilus influenzae Type b Capsular Polysaccharide

1992 • 34 citations

In vitro human antibody production to the Haemophilus influenzae type b capsular polysaccharide.

1987 • 32 citations

Use of the most JH-proximal human Ig H chain V region gene, VH6, in the expressed immune repertoire.

1993 • 28 citations

Isolation of germinal centerlike events from human spleen RNA. Somatic hypermutation of a clonally related VH6DJH rearrangement expressed with IgM, IgG, and IgA.

1993 • 23 citations

Human splenic IgM immunoglobulin transcripts are mutated at high frequency

1994 • 23 citations