The normal IGHV1-69–derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

1999 • 2,674 citations

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia

1999 • 2,557 citations

Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia

2001 • 1,110 citations

IMGT(R), the international ImMunoGeneTics information system(R)

2008 • 1,067 citations

Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

2002 • 530 citations

IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes

2004 • 524 citations

Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations

2006 • 507 citations

Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction.

1995 • 434 citations

Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia

2004 • 433 citations

Chronic lymphocytic leukemia: revelations from the B-cell receptor

2004 • 401 citations

Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.

1997 • 373 citations

Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity

2005 • 331 citations

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia

2003 • 330 citations

Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis

2007 • 328 citations

Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia

2004 • 280 citations

A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies

2008 • 264 citations

Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

2004 • 258 citations

IMGT, the international ImMunoGeneTics information system(R)

2004 • 249 citations

CpG Drives Human Transitional B Cells to Terminal Differentiation and Production of Natural Antibodies

2008 • 236 citations

Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features.

1997 • 230 citations

Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus–associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor–producing cells that occur mainly in type II cryoglobulinemia

2000 • 227 citations

Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status

2007 • 226 citations

Cd5 Maintains Tolerance in Anergic B Cells

2000 • 213 citations

Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity

2005 • 208 citations

Chronic Lymphocytic Leukemia Cells Recognize Conserved Epitopes Associated with Apoptosis and Oxidation

2008 • 204 citations

The immunodeficiency of chronic lymphocytic leukaemia

2008 • 179 citations

IL-6 Modulates CD5 Expression in B Cells from Patients with Lupus by Regulating DNA Methylation

2009 • 160 citations

Immunoglobulin Gene Mutations and Frequent Use of VH1-69 and VH4-34 Segments in Hepatitis C Virus-Positive and Hepatitis C Virus-Negative Nodal Marginal Zone B-Cell Lymphoma

2001 • 153 citations

The occurrence and significance of V gene mutations in B cell—Derived human malignancy

2001 • 124 citations

Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study

2008 • 119 citations

Hepatitis C Virus Drives the Unconstrained Monoclonal Expansion of VH1–69-Expressing Memory B Cells in Type II Cryoglobulinemia: A Model of Infection-Driven Lymphomagenesis

2005 • 105 citations

B-cell superantigens

1997 • 91 citations

Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire

2003 • 83 citations

Relationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody-associated cross-reactive idiotypes.

1991 • 79 citations

Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number.

1996 • 78 citations

Natural human antibodies to pneumococcus have distinctive molecular characteristics and protect against pneumococcal disease

2007 • 72 citations

Normal B Cells Express51p1-Encoded Ig Heavy Chains That Are Distinct From Those Expressed by Chronic Lymphocytic Leukemia B Cells

2001 • 69 citations

Acquired immune‐related and inflammatory conditions and subsequent chronic lymphocytic leukaemia

2007 • 58 citations

Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3

2007 • 55 citations

Expression of CD27 and CD23 on peripheral blood B lymphocytes in humans of different ages.

2009 • 47 citations

The Human Marginal Zone B Cell

2003 • 47 citations

Molecular Characterization of the V_H1‐Specific Variable Region Determinants Recognized by Anti‐Idiotypic Monoclonal Antibodies G6 and G8

1999 • 29 citations

Similar characteristics of the CDR3 of V_H1‐69/DP‐10 rearrangements in normal human peripheral blood and chronic lymphocytic leukaemia B cells

1998 • 27 citations

Computational identification of CDR3 sequence archetypes among immunoglobulin sequences in chronic lymphocytic leukemia

2008 • 24 citations

Transgenic Expression of a Human Polyreactive Ig Expressed in Chronic Lymphocytic Leukemia Generates Memory-Type B Cells That Respond to Nonspecific Immune Activation

2004 • 18 citations

patterns characteristic of unmutated CLL derived B-cell repertoire contains stereotypic IGHV1-69 The normal

2010 • 1 citations