Evidence for Involvement of a Hydrophobic Patch in Framework Region 1 of Human V4-34-Encoded Igs in Recognition of the Red Blood Cell I Antigen

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-.ANG. resolution

1981 • 1,286 citations

Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen

1994 • 585 citations

Interactions of protein antigens with antibodies.

1996 • 543 citations

Antibody framework residues affecting the conformation of the hypervariable loops

1992 • 507 citations

Crystal structure of aStaphylococcus aureusprotein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity

2000 • 474 citations

Structural repertoire of the human VH segments

1992 • 396 citations

Blood group ABH and Ii antigens of human erythrocytes: chemistry, polymorphism, and their developmental change.

1981 • 344 citations

Crystal structure of a T-cell receptor β-chain complexed with a superantigen

1996 • 285 citations

Recognition of a Cell-Surface Oligosaccharide of Pathogenic Salmonella by an Antibody Fab Fragment

1991 • 261 citations

Antigenic Specificities Related to the Cold Agglutinin Activity of Gamma M Globulins

1968 • 243 citations

The Immunological Evolution of Catalysis

1996 • 224 citations

Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens

1991 • 216 citations

VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities.

1992 • 214 citations

Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody—antigen interaction

1997 • 212 citations

Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype.

1991 • 204 citations

Structure of a single-chain antibody variable domain (Fv) fragment complexed with a carbohydrate antigen at 1.7-A resolution.

1994 • 155 citations

The Blood Group Ii System: A Carbohydrate Antigen System Defined by Naturally Monoclonal or Oligoclonal Autoantibodies of Man

1981 • 134 citations

Utilization of the VH4-21 Gene Segment by Anti-DNA Antibodies from Patients with Systemic Lupus Erythematosus

1993 • 111 citations

Identification of normal B‐cell counterparts of neoplastic cells which secrete cold agglutinins of anti‐I and anti‐i specificity

1989 • 101 citations

Human Monoclonal Antibodies against Blood Group Antigens Preferentially Express a VH4‐21 Variable Region Gene‐Associated Epitope

1991 • 98 citations

Antibodies to shared idiotypes as agents for analysis and therapy for human B cell tumors

1986 • 97 citations

The I Binding Specificity of Human VH4-34 (VH4-21) Encoded Antibodies is Determined by Both VHFramework Region 1 and Complementarity Determining Region 3

1996 • 96 citations

B-cell superantigens

1997 • 91 citations

The X-ray structure of an anti-tumour antibody in complex with antigen

1995 • 90 citations

Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment.

1993 • 88 citations

Staphylococcal protein A simultaneously interacts with framework region 1, complementarity-determining region 2, and framework region 3 on human VH3-encoded Igs.

1996 • 81 citations

Antigen-induced conformational changes in antibodies: A problem for structural prediction and design

1994 • 72 citations

An anti‐B cell autoantibody from Wiskott‐Aldrich syndrome which recognizes i blood group specificity on normal human B cells

1992 • 56 citations

Modulation of antibody affinity by a non‐contact residue

1993 • 44 citations

Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene: A possible link between infection and lupus

1995 • 43 citations

Recognition of Auto‐ and Exoantigens by V4‐34 Gene Encoded Antibodies

2000 • 39 citations

The primary structure of the Fab fragment of protein KAU, a monoclonal immunoglobulin M cold agglutinin.

1991 • 38 citations

B-cell superantigens?

1991 • 33 citations

Use of phage surface expression to analyze regions of human V4-34(VH4-21)-encoded IgG autoantibody required for recognition of DNA: no involvement of the 9G4 idiotope.

1996 • 31 citations

Human monoclonal antibodies encoded by the V4‐34 gene segment show cold agglutinin activity and variable multireactivity which correlates with the predicted charge of the heavy‐chain variable region

1998 • 31 citations

Three-Dimensional Structure of the Fab from a Human IgM Cold Agglutinin

2000 • 28 citations

Revenge of the microbes. Superantigens of the T and B cell lineage.

1994 • 27 citations

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