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Combination clinical trials with thymidine and fluorouracil: A phase I and clinical pharmacologic evaluation

Data up to Jan 2025

Published1980
Citations85
References19

Total Citations Per Year

Abstract

References (19)

Studies on Fluorinated Pyrimidines

1959 • 184 citations

An evaluation of the double thymidine block for synchronizing mammalian cells at the G1-S border*1

1971 • 181 citations

Biochemical Basis for Fluorouracil Neurotoxicity

1970 • 180 citations

The Incorporation of 5-Fluorouracil Into RNA and its Molecular Consequences

1969 • 117 citations

Identification of nucleosides and bases in serum and plasma samples by reverse-phase high performance liquid chromatography

1977 • 109 citations

Sequential and combination chemotherapy of advanced gastric cancer

1976 • 101 citations

Identification and Comparative Analysis of Thymidine Phosphorylase in the Plasma of Healthy Subjects and Cancer Patients: Brief Communication 2

1977 • 81 citations

Mutagenesis of Chinese hamster cells is facilitated by thymidine and deoxycytidine

1978 • 79 citations

Chemotherapy of disseminated breast cancer:Current status and prospects

1977 • 76 citations

Fluorouracil, methyl-ccnu and vincristine in cancer of the colon

1976 • 73 citations

Thymidine rescue of high-dose methotrexate in humans.

1978 • 66 citations

Transport and enzymic splitting of pyrimidine nucleosides in Ehrlich cells

1962 • 63 citations

Effects of 5-fluorouracil on 5-fluorodeoxyuridine 5'-monophosphate and 2-deoxyuridine 5'-monophosphate pools, and DNA synthesis in solid mouse L1210 and rat Walker 256 tumors.

1978 • 59 citations

Selective lethal effect of thymidine on human and mouse tumor cells

1977 • 55 citations

Role of catabolism in pyrimidine utilization for nucleic acid synthesis in vivo.

1972 • 46 citations

In Vivo Enhancement of 5-Fluorouracil Cytotoxicity to AKR Leukemia Cells by Thymidine in Mice<xref ref-type="fn" rid="FN2">2</xref>

1978 • 39 citations

Effect of excess thymidine on the growth of human melanoma cells transplanted in thymus deficient nude mice

1977 • 29 citations

Understanding the actions of carcinostatic drugs to improve chemotherapy: 5-fluorouracil

1978 • 17 citations

Differential response of two derivatives of the BHK21 hamster cell to thymidine

1967 • 11 citations

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Combination clinical trials with thymidine and fluorouracil: A phase I and clinical… (1980) – Cancer | Metascience Observatory Explorer