Interaction of drugs inhibiting different steps in the synthesis of DNA.

Enzyme and metabolic inhibitors

1963 • 1,529 citations

ANTAGONISTS OF NUCLEIC ACID DERIVATIVES

1954 • 427 citations

Specific Binding of 4-Amino Folic Acid Analogues by Folic Acid Reductase

1961 • 389 citations

The incorporation of 3H-cytosine arabinoside and its effect on murine leukemic cells (L5178Y)

1968 • 296 citations

A proposed mechanism of action of 1-β-d-arabinofuranosyl-cytosine as an inhibitor of the growth of leukemic cells

1962 • 282 citations

Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides.

1965 • 192 citations

Inhibition of ribonucleoside diphosphate reductase by 1-formylisoquinoline thiosemicarbazone and related compounds

1970 • 141 citations

Effect of cytosine arabinoside 5′-triphosphate on mammalian DNA polymerase

1969 • 135 citations

The Use of Combinations of Antimicrobial Drugs

1968 • 118 citations

Effects of Arabinonucleotides on Ribonucleotide Reduction by an Enzyme System from Rat Tumor

1967 • 116 citations

Evidence That Drugs in Multiple Combinations Have Materially Advanced the Treatment of Human Malignancies

1969 • 114 citations

Sequential Blocking of Metabolic Pathways in vivo

1951 • 107 citations

Metabolism of 1-beta-D-arabinofuranosylcytosine in L cells.

1965 • 106 citations

Combined antibacterial action in vitro of trimethoprim and sulphonamides. The in vitro nature of synergy.

1969 • 106 citations

Studies relating to the mode of action of methotrexate. II. Studies on sites of action in L-cells in vitro.

1969 • 72 citations

Drug Synergism in Antineoplastic Chemotherapy

1964 • 67 citations

The action of arabinosylcytosine on synchronously growing populations of mammalian cells

1968 • 64 citations

Some approaches to the therapeutic exploitation of metabolic sites of vulnerability of neoplastic cells.

1969 • 50 citations

Inhibition of DNA Polymerase by -D-Arabinosylcytosine and Reversal of Inhibition by Deoxycytidine-5'-triphosphate

1968 • 43 citations

MATHEMATICAL SIMULATION IN CHEMOTHERAPY*

1971 • 39 citations

AN ANALYSIS OF THE LACK OF DRUG SYNERGISM DURING SEQUENTIAL BLOCKADE OF DE NOVO PYRIMIDINE BIOSYNTHESIS.

1964 • 33 citations

Sequential Blockage as a Theoretical Basis for Drug Synergism

1963 • 28 citations

Evaluation of combination chemotherapy in vivo and in culture with l- -D-arabinofuranosylcytosine and 1-formylisoquinoline thiosemicarbazone.

1972 • 15 citations

Conference on obstacles to the control of acute leukemia. Formal discussion: some enzymatic considerations in combination chemotherapy.

1965 • 12 citations