5-fluorouracil and methotrexate combination chemotherapy: The effect of drug scheduling

Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism

1979 • 251 citations

Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.

1978 • 196 citations

Schedule-dependent antitumor effects of methotrexate and 5-fluorouracil.

1977 • 191 citations

Toward improved selectivity in cancer chemotherapy: the Richard and Hinda Rosenthal Foundation Award Lecture.

1979 • 90 citations

Combination chemotherapy: The interaction of methotrexate and 5-fluorouracil

1973 • 74 citations

The antileukemic effectiveness of 5-fluorouracil and methotrexate in the combination chemotherapy of advanced leukemia L1210 in mice.

1966 • 31 citations

Effect of sequence of administration of methotrexate, leucovorin, and 5-fluorouracil on mammary tumor growth and survival in syngeneic C3H mice.

1977 • 29 citations

Synergism of methotrexate with imuran and with 5-fluorouracil and their effects on hemolysin plaque-forming cell production in the mouse.

1974 • 22 citations

Schedule dependent effectiveness of CCNU and 5-fluorouracil in experimental chemotherapy

1977 • 18 citations

The fluoropyrimidines: Biochemical mechanisms and design of clinical trials

1978 • 16 citations

Combined effects of methotrexate and 5-fluoropyrimidine on human breast cancer cells in serum-free culture

1980 • 16 citations

Adjuvant postoperative chemotherapy with 5‐fluorouracil and methotrexate: Effect of schedule of administration on metastasis of 13762 mammary adenocarcinoma

1977 • 14 citations

Therapeutic consequences of antitumour drug interactions: Methotrexate and 5-fluorouracil in the chemotherapy of C3H mice with transplanted mammary adenocarcinoma

1978 • 9 citations

Synergism and schedule dependent cytotoxicity of cyclophosphamide and CCNU in experimental cancer chemotherapy

1978 • 8 citations

Vincristine-methotrexate combination chemotherapy and the influence of weight loss on experimental tumour growth

1979 • 7 citations

Lack of vincristine-cyclophosphamide potentiation in different experimental tumour lines

1979 • 7 citations

Schedule-dependent cytotoxicity of 5-fluorouracil and cyclophosphamide in experimental cancer chemotherapy

1980 • 6 citations

Fluoropyrimidine-induced antagonism to free and tightly bound methotrexate: Suppression of [14C] formate incorporation into RNA and protein

1980 • 5 citations

Cancer Chemotherapy: An Unexpected Drug Interaction

1976 • 5 citations

Antitumor Drug Interactions: Additional Data

1976 • 5 citations

Adriamycin/cyclophosphamide combination chemotherapy: The importance of drug scheduling

1979 • 4 citations