Advances in Rational Combination Chemotherapy

Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin)

1948 • 1,702 citations

Randomized Comparisons of Radiotherapy and Nitrosoureas for the Treatment of Malignant Glioma after Surgery

1980 • 1,625 citations

Primary Bioassay of Human Tumor Stem Cells

1977 • 1,625 citations

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

Quantitation of Differential Sensitivity of Human-Tumor Stem Cells to Anticancer Drugs

1978 • 982 citations

Hydroxyldaunomycin (adriamycin) combination chemotherapy in malignant lymphoma

1976 • 837 citations

EXPERIMENTAL EVALUATION OF POTENTIAL ANTICANCER AGENTS. XIII. ON THE CRITERIA AND KINETICS ASSOCIATED WITH "CURABILITY" OF EXPERIMENTAL LEUKEMIA.

1964 • 763 citations

NITROGEN MUSTARD THERAPY

1946 • 654 citations

Streptozocin Alone Compared with Streptozocin plus Fluorouracil in the Treatment of Advanced Islet-Cell Carcinoma

1980 • 638 citations

Primary osteogenic sarcoma. The rationale for preoperative chemotherapy and delayed surgery

1979 • 588 citations

Rationale for the use of alternating non-cross-resistant chemotherapy.

1982 • 545 citations

Effect of Methotrexate Therapy upon Choriocarcinoma and Chorioadenoma

1956 • 493 citations

ADVANCED DIFFUSE HISTIOCYTIC LYMPHOMA, A POTENTIALLY CURABLE DISEASE

1975 • 483 citations

Effects of Combined Drug Therapy on Metastatic Cancer of the Testis

1960 • 405 citations

Mouse myeloma tumor stem cells: a primary cell culture assay.

1971 • 395 citations

Circumvention of vincristine and Adriamycin resistance in vitro and in vivo by calcium influx blockers.

1983 • 384 citations

The intergroup rhabdomyosarcoma study.A preliminary report

1977 • 369 citations

5-Fluorouracil, Doxorubicin, and Mitomycin (FAM) Combination Chemotherapy for Advanced Gastric Cancer

1980 • 357 citations

Bleomycin, Adriamycin, Cyclophosphamide, Vincristine, and Prednisone (BACOP) Combination Chemotherapy in the Treatment of Advanced Diffuse Histiocytic Lymphoma

1976 • 349 citations

Hodgkin's Disease and Allied Disorders

1948 • 303 citations

The incorporation of 3H-cytosine arabinoside and its effect on murine leukemic cells (L5178Y)

1968 • 296 citations

A Randomized Trial of Adjuvant Chemotherapy and Immunotherapy in Cutaneous Melanoma

1982 • 282 citations

Comparison of in vitro methods to determine drug-induced cell lethality.

1976 • 278 citations

Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism

1979 • 251 citations

Probabilities of Eventually Developing or Dying of Cancer--United States, 1985

1985 • 241 citations

Chemotherapy of Thyroid Cancer with Adriamycin

1974 • 235 citations

The james ewing lecture. The relationship between tumor mass and resistance to chemotherapy. Implications for surgical adjuvant treatment of cancer

1983 • 230 citations

Preoperative chemotherapy and radiation therapy for patients with cancer of the esophagus: a potentially curative approach.

1984 • 226 citations

Cell kinetics and chemotherapy: a critical review.

1978 • 224 citations

Improved survival times in multiple myeloma treated with melphalan, prednisone, cyclophosphamide, vincristine and BCNU: M-2 protocol

1977 • 222 citations

NITROGEN MUSTARD THERAPY

1949 • 218 citations

Clinical management of advanced gastrointestinal cancer

1975 • 212 citations

Common Epithelial Cancer of the Ovary

1985 • 208 citations

Clonogenic and nonclonogenic in vitro chemosensitivity assays.

1985 • 208 citations

Combination chemotherapy with adriamycin and cyclophosphamide for advanced breast cancer

1975 • 207 citations

Transport and metabolism of deoxycytidine and 1-beta-D-arabinofuranosylcytosine into cultured Novikoff rat hepatoma cells, relationship to phosphorylation, and regulation of triphosphate synthesis.

1978 • 197 citations

The Use of Drugs in Combination for the Treatment of Cancer

1973 • 193 citations

Combination Chemotherapy of Advanced Diffuse Histiocytic Lymphoma with the Six-Drug COP-BLAM Regimen

1982 • 189 citations

Curability of ewing's sarcoma and considerations for future therapeutic trials

1978 • 182 citations

Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia

1977 • 180 citations

Cyclophosphamide, Vincristine, Methotrexate with Leucovorin Rescue, and Cytarabine (COMLA) Combination Sequential Chemotherapy for Advanced Diffuse Histiocytic Lymphoma

1980 • 161 citations

Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy.

1980 • 155 citations

The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.

1981 • 138 citations

Intensive Chemotherapy for Acute Myelogenous Leukemia

1981 • 135 citations

INDUCTION OF REMISSION IN HEPATOCELLULAR CARCINOMA WITH DOXORUBICIN

1978 • 135 citations

The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine.

1978 • 133 citations

Chemotherapy of metastatic testis cancer:Results in 154 patients

1966 • 132 citations

Combination chemotherapy for small cell carcinoma of the lung: continuous versus alternating non-cross-resistant combinations.

1982 • 131 citations

Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-beta-D- arabinofuranosylcytosine.

1984 • 127 citations

Cyclophosphamide, vincristine, adriamycin, and DTIC (CYVADIC) combination chemotherapy for the treatment of advanced sarcomas.

1980 • 123 citations

The employment of combinations of drugs in the chemotherapy of neoplasia: a review.

1957 • 122 citations

Testicular Germ-Cell Neoplasms: Recent Advances in Diagnosis and Therapy

1979 • 116 citations

Therapy of acute lymphoblastic leukemia in childhood

1980 • 115 citations

Synergistic lethal effect of cis-dichlorodiammineplatinum and 1-beta-D-arabinofuranosylcytosine.

1981 • 115 citations

Chemotherapy of Metastatic Bladder Cancer

1980 • 110 citations

Sequential Blocking of Metabolic Pathways in vivo

1951 • 107 citations

An Eastern Cooperative Oncology Group evaluation of combinations of methyl-CCNU, mitomycin C, Adriamycin, and 5-fluorouracil in advanced measurable gastric cancer (EST 2277).

1984 • 105 citations

Clinical, biological, and biochemical effect of pyrazofurin.

1978 • 103 citations

Primary liver cancer.A review of the clinical features, blood groups, serum enzymes, therapy, and survival of 65 cases

1974 • 99 citations

Integration of chemotherapy into combined modality treatment of solid tumors

1976 • 98 citations

Regulation of Enzymic Activity by Metabolites

1969 • 94 citations

Therapy of acute lymphoblastic leukemia in childhood

1980 • 92 citations

Augmentation of 5-fluorouracil cytotoxicity in human colon cancer cells by dipyridamole.

1985 • 91 citations

High-dose methotrexate in osteogenic sarcoma: a 5-year experience.

1978 • 90 citations

Chemotherapy for multiple myeloma

1984 • 90 citations

Stage-related combined modality treatment of retinoblastoma. Results of a prospective study

1980 • 90 citations

Chemotherapy of Mouse Myeloma: Quantitative Cell Cultures Predictive of Response In Vivo

1973 • 88 citations

Potentiation of methotrexate toxicity by dipyridamole.

1984 • 88 citations

Chemotherapy strategies to improve the control of Hodgkin's disease: the Richard and Hinda Rosenthal Foundation Award Lecture.

1982 • 86 citations

Controversies in the therapy of acute myelogenous leukemia

1982 • 86 citations

Response of L1210 to combinations of cytosine arabinoside and VM-26 or VP16-213

1975 • 85 citations

Pharmacologic Principles of Cancer Treatment

1983 • 75 citations

Intensive chemotherapy as primary treatment for rhabdomyosarcoma of the pelvis

1975 • 72 citations

EXPERIMENTAL EVALUATION OF POTENTIAL ANTICANCER AGENTS. XIV. FURTHER STUDY OF CERTAIN BASIC CONCEPTS UNDERLYING CHEMOTHERAPY OF LEUKEMIA.

1965 • 72 citations

Enhancement by tetrahydrouridine of 1-beta-D-arabinofuranosylcytosine (cytarabine) oral activity in L1210 leukemic mice.

1970 • 70 citations

Combination chemotherapy in vitro with cis-dichlorodiammineplatinum(II).

1976 • 69 citations

Genetic, biochemical, and cross-resistance studies with mutants of Chinese hamster ovary cells resistant to the anticancer drugs, VM-26 and VP16-213.

1983 • 68 citations

Trophoblastic Disease: Natural History, Diagnosis, and Treatment

1971 • 68 citations

The relevance of certain concepts of cell cycle kinetics

1978 • 65 citations

The National Cancer Chemotherapy Program

1982 • 65 citations

Drug and Hormone Resistance in Neoplasia

2019 • 63 citations

o,p'DDD Therapy in Invasive Adrenocortical Carcinoma

1975 • 63 citations

Schedule-dependent cytotoxicity of methotrexate and 5-fluorouracil in human colon and breast tumor cell lines.

1980 • 59 citations

Mechanism of synergistic cell killing when methotrexate precedes cytosine arabinoside: study of L1210 and human leukemic cells.

1979 • 57 citations

Kinetic studies on phosphorylation of 5-azacytidine with the purified uridine-cytidine kinase from calf thymus.

1974 • 56 citations

Interaction of drugs inhibiting different steps in the synthesis of DNA.

1972 • 55 citations

DOXORUBICIN/B.C.N.U. CHEMOTHERAPY FOR MULTIPLE MYELOMA IN RELAPSE

1976 • 53 citations

Approaches to the Combination Chemotherapy of Transplantable Neoplasms

2015 • 52 citations

Further investigation of the relation between the clinical and tissue culture response to chemotherapeutic agents on human cancer

1962 • 51 citations

The chemotherapy of gestational trophoblastic disease: principles of clinical management.

1972 • 50 citations

Effects of combinations of azaserine and of 6-diazo-5-oxo-L-norleucine with purine analogs and other antimetabolites on the growth of two mouse mammary carcinomas.

1957 • 50 citations

In Vitro Methods to Predict for Patient Response to Chemotherapy

1980 • 49 citations

Attempts at dual blocking of biochemical events in cancer chemotherapy.

1954 • 48 citations

Biochemical mechanisms for the synergism between 6-thioguanine and 6-(methylmercapto)purine ribonucleoside in sarcoma 180 cells.

1972 • 47 citations

Potentiation of etoposide-induced DNA damage by calcium antagonists in L1210 cells in vitro.

1984 • 46 citations

Tamoxifen and 5-fluorouracil in breast cancer: cytotoxic synergism in vitro.

1983 • 45 citations

Cyclophosphamide, adriamycin, methotrexate, and procarbazine (CAMP)--effective four-drug combination chemotherapy for metastatic non-oat cell bronchogenic carcinoma.

1976 • 45 citations

The impact of chemotherapy on advanced neuroblastoma. Survival of patients diagnosed in 1956, 1962, and 1966–68 in Children's Cancer Study Group A

1974 • 44 citations

Synergistic action of 5-aza-2'-deoxycytidine and 3-deazauridine on L1210 leukemic cells and EMT6 tumor cells.

1979 • 41 citations

Combination chemotherapy with cyclophosphamide, vincristine, and prednisone in the treatment of refractory chronic lymphocytic leukemia.

1979 • 40 citations

Dipyridamole inhibits reversion by thymidine of methotrexate effect and increases drug uptake in Sarcoma 180 cells.

1984 • 40 citations

The Chemotherapy of Gestational Trophoblastic Disease

1972 • 39 citations

Mechanism of the growth inhibition potentiation arising from combination of 6-mercaptopurine with 6-(methylmercapto)purine ribonucleoside.

1970 • 37 citations

Modern approaches to the management of chronic granulocytic leukemia.

1978 • 36 citations

Rational basis for chemotherapy

1984 • 35 citations

Clinical development of anticancer agents--a National Cancer Institute perspective.

1984 • 33 citations

Approaches to the Rational Combination of Antimetabolites for Cancer Chemotherapy

1975 • 32 citations

Burkitt's lymphoma--a model for intensive chemotherapy.

1977 • 31 citations

Pyrazofurin enhancement of 5-azacytidine antitumor activity in L5178Y and human leukemia cells.

1978 • 31 citations

Synergistic and antagonistic interactions of methotrexate and 1-β-D-arabinofuranosylcytosine in hepatoma cells

1981 • 31 citations

Combination chemotherapy: The antagonism of methotrexate and cytosine arabinoside

1973 • 31 citations

Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity

1981 • 30 citations

Combination chemotherapy in advanced lung cancer with increased survival

1976 • 29 citations

Enhancement of the antiproliferative action of 1- -D-arabinofuranosylcytosine by methotrexate in murine leukemic cells (L5178Y).

1973 • 28 citations

Multiple myeloma—intermittent, combination chemotherapy compared to continuous therapy

1972 • 28 citations

Combination chemotherapy in vitro. IV. Response of human colon carcinoma cells to combinations using cis-diamminedichloroplatinum.

1979 • 28 citations

Factors governing the modulation of vinca-alkaloid resistance in doxorubicin-resistant cells by the calmodulin inhibitor trifluoperazine

1986 • 24 citations

Biology of Tumor Growth

1983 • 21 citations

Sequential infusions of methotrexate and 5-fluorouracil in advanced cancer: pharmacology, toxicity, and response.

1985 • 21 citations

RATIONALE OF COMBINATION CHEMOTHERAPY

1980 • 20 citations

Response and survival of patients with metastatic neuroblastoma after combination chemotherapy with adriamycin (NSC-123127), cyclophosphamide (NSC-26271), and vincristine (NSC-67574).

1974 • 18 citations

Schedule-dependent synergism of combinations of hydroxyurea with adriamycin and 1-beta-D-arabinofuranosylcytosine with adriamycin.

1981 • 17 citations

Adjuvant chemotherapy for stage D1 adenocarcinoma of prostate

1983 • 16 citations

Calmodulin inhibitor trifluoperazine selectively enhances cytotoxic effects of strong VS weak DNA binding antitumor drugs in doxorubicin-resistant P388 mouse leukemia cells

1985 • 14 citations

Overview of four clinical studies of chemotherapy for stage III and IV non-Hodgkin's lymphomas by the Cancer and Leukemia Group B.

1977 • 14 citations

Effect of N-(phosphonacetyl)-L-aspartate on 5-azacytidine metabolism in P388 and L1210 cells.

1981 • 12 citations

Chemo-immunotherapy for unresectable bronchogenic carcinoma.

1978 • 11 citations

Tamoxifen and 5-fluorouracil in breast cancer: modulation of cellular RNA.

1983 • 11 citations

Neuroblastoma and Wilms' Tumor

1977 • 10 citations

Regulation of rRNA synthesis and processing in animal cells. Effect of nucleoside analogues

1982 • 9 citations

Sequence-dependent synergism between dichloromethotrexate and cisplatin in a human colon carcinoma cell line.

1985 • 9 citations

Manual of Bedside Oncology.

1983 • 8 citations

Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.

1982 • 8 citations

In Vitro Assay for Sensitivity to Anticancer Drugs

1985 • 6 citations

The Evolution of Cancer Chemotherapy

1985 • 6 citations

Diagnosis and Treatment of Malignant Carcinoid Syndrome

1974 • 5 citations

Use of cisplatin, cyclophosphamide, vincristine, and doxorubicin for the treatment of non-small cell lung cancer.

1984 • 5 citations

Experiments on the combined chemotherapeutic influence on inoperable, x-ray unsuitable patients suffering from bronchial carcinoma; clinical studies with combinations of TEM and antimetabolites.

1957 • 3 citations

Biochemical Modulation as a Guide to Rational Combination Chemotherapy for the Treatment of Cancer

1983 • 3 citations

The design of rational combination chemotherapy for cancer.

1984 • 1 citations