THE BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ACTION AND EFFECTS OF THE FOLIC ACID ANTAGONISTS.

ENZYMATIC REDUCTION OF FOLIC ACID AND DIHYDROFOLIC ACID TO TETRAHYDROFOLIC ACID

1957 • 416 citations

Specific Binding of 4-Amino Folic Acid Analogues by Folic Acid Reductase

1961 • 389 citations

Inhibition of Dihydrofolic Reductase by Aminopterin and Amethopterin.

1958 • 217 citations

Morphologic and Physiologic Effects of Chemotherapeutic Agents in Psoriasis11From the Dermatology Service, General Medicine Branch, National Cancer Institute, (National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare) Bethesda, Maryland.

1959 • 154 citations

Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells

1961 • 152 citations

On the Mechanism of Action of Aminopterin.

1950 • 141 citations

Folic Acid Coenzymes

1958 • 82 citations

Increased Level of Dihydrofolic Reductase in Leucocytes of Patients Treated with Amethopterin

1962 • 79 citations

Folic acid antagonists in cancer chemotherapy.

1962 • 79 citations

Purification and Properties of Folic Acid Reductase from Chicken Liver

1960 • 73 citations

The physiological disposition of some anticancer agents.

1959 • 73 citations

Studies on the folic acid vitamins.IV. The persistence of amethopterin in mammalian tissues

1960 • 62 citations

Agents Which Influence Nucleic Acid Metabolism

1960 • 55 citations

REVERSAL OF AMINOPTERIN AND AMETHOPTERIN TOXICITY BY CITROVORUM FACTOR

1950 • 53 citations

STUDIES OF THE ACTION OF 4‐AMINOPTEROYLGLUTAMIC ACID AND ITS CONCERNS IN MAMMALS

1950 • 53 citations

Persistence of Amethopterin in Normal Mouse Tissues.

1953 • 45 citations

Dihydrofolic Acid Reductase¹

1958 • 43 citations

Studies on the mechanism of action of chemotherapeutic agents in cancer. II.Requirements for the prevention of aminopterin toxicity by folic acid in mice

1950 • 28 citations

Studies on drug resistance in mammalian cells. I. Amethopterin resistance in mouse fibroblasts.

1959 • 15 citations

Chromatographic studies of purine metabolism. III. Effects of A-methopterin on formate-C14 utilization in mice bearing susceptible and dependent L1210 leukemia

1958 • 11 citations

Studies on the toxicity of amethopterin and tetrahydroamethopterin in chicks

1961 • 8 citations

Anticancer Agents and Nucleic Acid Metabolism of Isolated Human Leukocytes

1957 • 7 citations