Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

1949 • 16,078 citations

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter

1960 • 7,610 citations

The precision of ultraviolet absorption measurements in the Schmidt-Thannhauser procedure for nucleic acid estimation

1962 • 1,066 citations

Comparison of the Sensitivity of Normal Hematopoietic and Transplanted Lymphoma Colony-Forming Cells to Chemotherapeutic Agents Administered <italic>In Vivo</italic><xref ref-type="fn" rid="FN2">2</xref>

1966 • 537 citations

Crystalline Dihydropteroylglutamic Acid

1960 • 461 citations

Studies on unbalanced growth in tissue culture. I. Induction and consequences of thymidine deficiency.

1960 • 340 citations

Antimetabolite-metabolite combination cancer chemotherapy.Effects of intra-arterial methotrexate—intramuscular citrovorum factor therapy in human cancer

1959 • 319 citations

Inhibition of leukemias in man by L-asparaginase.

1967 • 276 citations

Enzymatic Reduction of Dihydrofolic Acid

1958 • 251 citations

Statistical Methods in Research

1950 • 227 citations

THE MECHANISM OF ACTION OF THE FOLATE ANTAGONISTS IN MAN.

1963 • 226 citations

Studies of Sequential and Combination Antimetabolite Therapy in Acute Leukemia: 6-Mercaptopurine and Methotrexate

1961 • 218 citations

Inhibition of Dihydrofolic Reductase by Aminopterin and Amethopterin.

1958 • 217 citations

Studies on the Inhibition of Dihydrofolate Reductase by the Folate Antagonists

1964 • 176 citations

Defective transport of amethopterin (methotrexate) as a mechanism of resistance to the antimetabolite in L5178Y leukemic cells

1962 • 172 citations

Comparison of the sensitivity of normal hematopoietic and transplanted lymphoma colony-forming cells to chemotherapeutic agents administered in vivo

1967 • 141 citations

CHEMOTHERAPY OF CHORIO CARCINOMA AND RELATED TROPHOBLASTIC TUMORS IN WOMEN

1958 • 136 citations

Eradication Of Leukaemic Cells (L1210) by Methotrexate and Methotrexate Plus Citrovorum Factor

1966 • 112 citations

Dihydrofolate Reductase from a Resistant Subline of the L1210 Lymphoma

1967 • 109 citations

Uptake as a Determinant of Methotrexate Response in Mouse Leukemias

1965 • 107 citations

Modes of uptake of methotrexate by normal and leukemic human leukocytes in vitro and their relation to drug response.

1968 • 101 citations

STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES. IV. TETRAHYDROFOLATE-DEPENDENT ENZYME SYSTEMS AND DIHYDROFOLIC REDUCTASE*

1963 • 94 citations

THE “INDUCTION” OF DIHYDROFOLIC REDUCTASE ACTIVITY IN LEUKOCYTES AND ERYTHROCYTES OF PATIENTS TREATED WITH AMETHOPTERIN*

1963 • 92 citations

Proliferative Activity of Blast Cells in Leukemia and Myelofibrosis

1965 • 83 citations

Methotrexate Displacement in Man*

1964 • 80 citations

Increase of dihydrofolate reductase activity in cultured mammalian cells after exposure to methotrexate.

1967 • 74 citations

Methotrexate infusions and intensive supportive care in the management of children with acute lymphocytic leukemia: follow-up report.

1967 • 71 citations

The Enzymatic Mechanisms for Deoxythymidine Synthesis in Human Leukocytes

1967 • 68 citations

Comparison of the Proliferative Capacity of Acute Leukæmia Cells in Bone Marrow and Blood

1962 • 65 citations

Biochemical studies of human tumors. II.In vitro estimation of individual tumor sensitivity to anticancer agents

1966 • 62 citations

Studies on the folic acid vitamins. VII. The effects of large doses of amethopterin in patients with cancer.

1962 • 62 citations

Malignant lymphoma involving the jaw in African children: Treatment with methotrexate

1963 • 59 citations

The role of the folate coenzymes in cellular division. A review.

1962 • 57 citations

The enzymatic mechanisms for deoxythymidine synthesis in human leukocytes

1969 • 54 citations

An improved tissue culture assay. II. Cytotoxicity studies with antibiotics, chemicals, and solvents.

1959 • 54 citations

Further investigation of the relation between the clinical and tissue culture response to chemotherapeutic agents on human cancer

1962 • 51 citations

CHEMOTHERAPY OF CHORIOCARCINOMA AND RELATED TROPHOBLASTIC TUMORS IN WOMEN

1959 • 49 citations

The effect of reduced derivatives of folic acid on toxicity and antileukemic effect of methotrexate in mice

1963 • 46 citations

Combination Therapy of Adult Acute Myelogenous Leukemia

1965 • 44 citations

Effects of cytosine arabinoside on the cell viability and uptake of deoxypyrimidine nucleosides in 15178Y cells

1968 • 44 citations

Sensitivity of L Cells in Exponential and Stationary Phase to 5-Fluorouracil

1967 • 43 citations

Clinical pharmacologic studies of L‐asparaginase

1970 • 34 citations

Studies on the management of mouse leukemia (L1210) with antagonists of folic acid.

1955 • 32 citations

Statistical Methods in Research.

1950 • 32 citations

Metabolism of human leukocytes in vitro. I. Effects of A-methopterin on formate-C14 incorporation.

1957 • 32 citations

The precision of ultraviolet absorption measurements in the Schmidt-Thannhauser procedure for nucleic acid estimation

1962 • 28 citations

Prediction of in Vivo Cytotoxicity of Chemotherapeutic Agents by Their Effect on Malignant Leukocytes in Vitro

1967 • 27 citations

Correlations of the biochemical and clinical effects of 6-azauridine in patients with leukemia

1962 • 25 citations

INTRAVENOUS METHOTREXATE (AMETHOPTERIN) THERAPY IN THE TREATMENT OF ACUTE LEUKEMIA

1963 • 25 citations

Acute Leukemia Treated With Divided Doses of Methotrexate

1965 • 24 citations

Head and neck cancer. 3. Toxicity of 24-hour infusions of methotrexate (NSC-740) and protection by leucovorin (NSC-3590) in patients with epidermoid carcinomas.

1967 • 20 citations

STUDIES ON THE MECHANISM OF HUMAN TUMOR RESISTANCE TO THE FLUORINATED PYRIMIDINES.

1964 • 17 citations

Effects of Chemotherapeutic Agents on Metabolism of Human Acute Leukemia Cells in vitro.

1958 • 15 citations

An Evaluation of the Variance of Leukocyte Counts as Performed with the Hemocytometer, Coulter, and Fisher Instruments

1966 • 14 citations

The Enzymatic Mechanisms for Deoxythymidine Synthesis in Human Leukocytes

1968 • 11 citations

Human Leukocyte Metabolism in Vitro

1966 • 10 citations

The reduction of folate and of dihydrofolate by homogenates of leukocytes from patients with leukemia or with myeloid metaplasia.

1967 • 9 citations

Effects of folinic acid on amethopterin-induced inhibition of the Ehrlich ascites carcinoma.

1962 • 7 citations

Decreased de novo DNA-Thymine Synthesis and Increased Thymidine-3H Incorporation into DNA by Human Bone Marrow Cultured with Aminopterin.

1967 • 6 citations

Malignant Lymphoma Involving the Jaw in African Children: Treatment with Methotrexate

1963 • 2 citations

A correlation of clinical observations to in vitro sensitivity test for cancer chemotherapy.

1962 • 2 citations

PREPARATION OF NORMAL AND MALIGNANT HUMAN CELLS FOR STUDY OF RESISTANCE.

1964 • 1 citations