AMPA Receptor Trafficking at Excitatory Synapses

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

Activity-dependent scaling of quantal amplitude in neocortical neurons

1998 • 2,213 citations

The molecular basis of CaMKII function in synaptic and behavioural memory

2002 • 1,855 citations

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

1992 • 1,675 citations

Metaplasticity: the plasticity of synaptic plasticity

1996 • 1,638 citations

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

1996 • 1,589 citations

Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons

2001 • 1,523 citations

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

2000 • 1,507 citations

Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice

1995 • 1,342 citations

PSD-95 Involvement in Maturation of Excitatory Synapses

2000 • 1,238 citations

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

1990 • 1,234 citations

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

1997 • 1,228 citations

Evidence for silent synapses: Implications for the expression of LTP

1995 • 1,212 citations

PDZ Domains and the Organization of Supramolecular Complexes

2001 • 1,203 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

1989 • 1,114 citations

Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall

2002 • 1,090 citations

Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

2000 • 1,086 citations

Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

2000 • 1,085 citations

Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting

2000 • 1,076 citations

Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons

2001 • 1,073 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation

1989 • 1,015 citations

Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus

2000 • 967 citations

Activation of Synaptic NMDA Receptors Induces Membrane Insertion of New AMPA Receptors and LTP in Cultured Hippocampal Neurons

2001 • 898 citations

GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors

1997 • 866 citations

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

1997 • 866 citations

Ca ²⁺ /calmodulin-kinase II enhances channel conductance of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors

1999 • 836 citations

Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels

1991 • 827 citations

Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices

1990 • 803 citations

Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus

1998 • 798 citations

Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning

1999 • 794 citations

The Tetrameric Structure of a Glutamate Receptor Channel

1998 • 790 citations

Long-term potentiation and functional synapse induction in developing hippocampus

1996 • 787 citations

Phosphorylation of the AMPA Receptor GluR1 Subunit Is Required for Synaptic Plasticity and Retention of Spatial Memory

2003 • 782 citations

Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability

1991 • 774 citations

Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity

2002 • 756 citations

Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number

2002 • 729 citations

Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD

2000 • 728 citations

A critical period for long-term potentiation at thalamocortical synapses

1995 • 702 citations

Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation

1998 • 693 citations

Presynaptic mechanism for long-term potentiation in the hippocampus

1990 • 691 citations

Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity

1999 • 690 citations

Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization

2000 • 687 citations

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68

2000 • 683 citations

An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression

1993 • 678 citations

Different modes of expression of AMPA and NMDA receptors in hippocampal synapses

1999 • 673 citations

Structure of a glutamate-receptor ligand-binding core in complex with kainate

1998 • 672 citations

Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons

2001 • 657 citations

Mechanism of glutamate receptor desensitization

2002 • 650 citations

Control of GluR1 AMPA Receptor Function by cAMP-Dependent Protein Kinase

2000 • 646 citations

Induction of CRE-Mediated Gene Expression by Stimuli That Generate Long-Lasting LTP in Area CA1 of the Hippocampus

1996 • 594 citations

The mouse stargazer gene encodes a neuronal Ca2+-channel γ subunit

1998 • 580 citations

Maturation of a Central Glutamatergic Synapse

1996 • 551 citations

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

2000 • 550 citations

Synaptic Strength Regulated by Palmitate Cycling on PSD-95

2002 • 547 citations

Two Distinct Forms of Long-Term Depression Coexist in CA1 Hippocampal Pyramidal Cells

1997 • 547 citations

NSF Binding to GluR2 Regulates Synaptic Transmission

1998 • 542 citations

Phosphorylation of the AMPA Receptor Subunit GluR2 Differentially Regulates Its Interaction with PDZ Domain-Containing Proteins

2000 • 542 citations

Internalization of ionotropic glutamate receptors in response to mGluR activation

2001 • 540 citations

Clustering of AMPA Receptors by the Synaptic PDZ Domain–Containing Protein PICK1

1999 • 540 citations

Modulation of AMPA receptor unitary conductance by synaptic activity

1998 • 531 citations

Regulation of AMPA receptor lateral movements

2002 • 518 citations

Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins

2003 • 518 citations

Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP

1988 • 512 citations

Selective Induction of LTP and LTD by Postsynaptic [Ca²⁺]_i Elevation

1999 • 512 citations

Silent Synapses during Development of Thalamocortical Inputs

1997 • 502 citations

Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses

1999 • 496 citations

A persistent postsynaptic modification mediates long-term potentiation in the hippocampus

1988 • 496 citations

Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2

1996 • 494 citations

Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons

1997 • 493 citations

Impairment of Suckling Response, Trigeminal Neuronal Pattern Formation, and Hippocampal LTD in NMDA Receptor ε2 Subunit Mutant Mice

1996 • 486 citations

Expression of Cerebellar Long-Term Depression Requires Postsynaptic Clathrin-Mediated Endocytosis

2000 • 483 citations

PDZ Proteins Organize Synaptic Signaling Pathways

1998 • 474 citations

Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures

1999 • 462 citations

Synaptic Clustering of AMPA Receptors by the Extracellular Immediate-Early Gene Product Narp

1999 • 457 citations

PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands

1998 • 455 citations

Gating of CaMKII by cAMP-Regulated Protein Phosphatase Activity During LTP

1998 • 452 citations

Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism.

1995 • 451 citations

Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype

2000 • 450 citations

Clathrin Adaptor AP2 and NSF Interact with Overlapping Sites of GluR2 and Play Distinct Roles in AMPA Receptor Trafficking and Hippocampal LTD

2002 • 437 citations

Phosphorylation of the α-Amino-3-hydroxy-5-methylisoxazole4-propionic Acid Receptor GluR1 Subunit by Calcium/ Calmodulin-dependent Kinase II

1997 • 434 citations

Protein kinase Mζ is necessary and sufficient for LTP maintenance

2002 • 427 citations

Postnatal synaptic potentiation: Delivery of GluR4-containing AMPA receptors by spontaneous activity

2000 • 427 citations

Dynamin-dependent endocytosis of ionotropic glutamate receptors

1999 • 425 citations

N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1

1994 • 419 citations

SAP97 Is Associated with the α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR1 Subunit

1998 • 415 citations

SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A.

1993 • 415 citations

Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons

1999 • 399 citations

The role of receptor diffusion in the organization of the postsynaptic membrane

2003 • 398 citations

Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors

1998 • 396 citations

Heterogeneity in the Molecular Composition of Excitatory Postsynaptic Sites during Development of Hippocampal Neurons in Culture

1998 • 396 citations

Identification of the Ca2+/Calmodulin-dependent Protein Kinase II Regulatory Phosphorylation Site in the α-Amino-3-hydroxyl-5-methyl4-isoxazole-propionate-type Glutamate Receptor

1997 • 391 citations

Cerebellar Long-Term Depression Requires PKC-Regulated Interactions between GluR2/3 and PDZ Domain–Containing Proteins

2000 • 381 citations

Interaction of ion channels and receptors with PDZ domain proteins

1997 • 362 citations

Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression

2001 • 361 citations

The AMPA Receptor GluR2 C Terminus Can Mediate a Reversible, ATP-Dependent Interaction with NSF and α- and β-SNAPs

1998 • 355 citations

Novel Anchorage of GluR2/3 to the Postsynaptic Density by the AMPA Receptor–Binding Protein ABP

1998 • 354 citations

Dynamics and Regulation of Clathrin Coats at Specialized Endocytic Zones of Dendrites and Spines

2002 • 346 citations

Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons

2003 • 346 citations

Activity Coregulates Quantal AMPA and NMDA Currents at Neocortical Synapses

2000 • 344 citations

Participation of Postsynaptic PKC in Cerebellar Long-Term Depression in Culture

1991 • 340 citations

RNA Editing at Arg607 Controls AMPA Receptor Exit from the Endoplasmic Reticulum

2002 • 338 citations

Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors

1998 • 336 citations

Protein palmitoylation: a regulator of neuronal development and function

2002 • 334 citations

Postsynaptic Density-95 Mimics and Occludes Hippocampal Long-Term Potentiation and Enhances Long-Term Depression

2003 • 333 citations

Requirement of AMPA Receptor GluR2 Phosphorylation for Cerebellar Long-Term Depression

2003 • 333 citations

PDZ Proteins Interacting with C-Terminal GluR2/3 Are Involved in a PKC-Dependent Regulation of AMPA Receptors at Hippocampal Synapses

2000 • 328 citations

Synaptic Targeting of the Postsynaptic Density Protein PSD-95 Mediated by Lipid and Protein Motifs

1999 • 327 citations

Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region

1995 • 326 citations

A developmental switch in the signaling cascades for LTP induction

2002 • 322 citations

PICK1 Targets Activated Protein Kinase Cα to AMPA Receptor Clusters in Spines of Hippocampal Neurons and Reduces Surface Levels of the AMPA-Type Glutamate Receptor Subunit 2

2001 • 322 citations

Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor

1994 • 318 citations

Mammalian ionotropic glutamate receptors

1993 • 312 citations

Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2

2003 • 302 citations

Surface Expression of AMPA Receptors in Hippocampal Neurons Is Regulated by an NSF-Dependent Mechanism

1999 • 301 citations

Experience Strengthening Transmission by Driving AMPA Receptors into Synapses

2003 • 300 citations

Mutagenesis Reveals a Role for ABP/GRIP Binding to GluR2 in Synaptic Surface Accumulation of the AMPA Receptor

2000 • 295 citations

Regulation of AMPA Receptor GluR1 Subunit Surface Expression by a 4.1N-Linked Actin Cytoskeletal Association

2000 • 295 citations

NMDA Receptor Content of Synapses in Stratum Radiatum of the Hippocampal CA1 Area

2000 • 294 citations

Topology profile for a glutamate receptor: Three transmembrane domains and a channel-lining reentrant membrane loop

1995 • 293 citations

Ubiquitin and AP180 Regulate the Abundance of GLR-1 Glutamate Receptors at Postsynaptic Elements in C. elegans

2002 • 293 citations

Hippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction

1999 • 290 citations

Activation of Silent Synapses by Rapid Activity-Dependent Synaptic Recruitment of AMPA Receptors

2001 • 284 citations

Development of Excitatory Circuitry in the Hippocampus

1998 • 279 citations

Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons

2000 • 272 citations

LIN-10 Is a Shared Component of the Polarized Protein Localization Pathways in Neurons and Epithelia

1998 • 271 citations

Phosphorylation of Serine‐880 in GluR2 by Protein Kinase C Prevents Its C Terminus from Binding with Glutamate Receptor‐Interacting Protein

1999 • 260 citations

Synapse-Associated Protein 97 Selectively Associates with a Subset of AMPA Receptors Early in their Biosynthetic Pathway

2001 • 259 citations

Interaction between GRIP and Liprin-α/SYD2 Is Required for AMPA Receptor Targeting

2002 • 249 citations

Synaptic Transmission and Plasticity in the Absence of AMPA Glutamate Receptor GluR2 and GluR3

2003 • 249 citations

Narp and NP1 Form Heterocomplexes that Function in Developmental and Activity-Dependent Synaptic Plasticity

2003 • 245 citations

AMPA receptor trafficking and long-term potentiation

2003 • 237 citations

Activation of protein kinase C induces a long-term depression of glutamate sensitivity of cerebellar Purkinje cells. An in vitro study

1988 • 234 citations

Characterization of the Glutamate Receptor-Interacting Proteins GRIP1 and GRIP2

1999 • 231 citations

Contribution of cytoskeleton to the internalization of AMPA receptors

2001 • 226 citations

Rapid and Reversible Effects of Activity on Acetylcholine Receptor Density at the Neuromuscular Junction in Vivo

1999 • 223 citations

Rapid, Activation-Induced Redistribution of Ionotropic Glutamate Receptors in Cultured Hippocampal Neurons

1999 • 214 citations

Rapid and Differential Regulation of AMPA and Kainate Receptors at Hippocampal Mossy Fibre Synapses by PICK1 and GRIP

2003 • 213 citations

The protein kinase Cα binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits

1999 • 209 citations

Expression mechanisms underlying long-term potentiation: a postsynaptic view

2003 • 198 citations

Molecular cloning and development analysis of a new glutamate receptor subunit isoform in cerebellum

1992 • 194 citations

NSF ATPase and α-/β-SNAPs Disassemble the AMPA Receptor-PICK1 Complex

2002 • 189 citations

Synapse-Associated Protein-97 Isoform-Specific Regulation of Surface AMPA Receptors and Synaptic Function in Cultured Neurons

2003 • 188 citations

Silent Synapses in the Developing Rat Visual Cortex: Evidence for Postsynaptic Expression of Synaptic Plasticity

1998 • 182 citations

Multiple Mechanisms for the Potentiation of AMPA Receptor-Mediated Transmission by α-Ca²⁺/Calmodulin-Dependent Protein Kinase II

2002 • 177 citations

Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors

2001 • 172 citations

Association of AMPA Receptors with a Subset of Glutamate Receptor-Interacting ProteinIn Vivo

1999 • 171 citations

Rapid Increase in Clusters of Presynaptic Proteins at Onset of Long-Lasting Potentiation

2001 • 168 citations

Structural determinants of allosteric regulation in alternatively spliced AMPA receptors

1995 • 164 citations

Interaction between Liprin-α and GIT1 Is Required for AMPA Receptor Targeting

2003 • 160 citations

Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core

2002 • 158 citations

Immunogold localization of AMPA and NMDA receptors in somatic sensory cortex of albino rat

1999 • 154 citations

GRASP-1

2000 • 153 citations

A-to-I Editing

2002 • 149 citations

Glutamate regulates actin-based motility in axonal filopodia

2001 • 143 citations

Postsynaptically Silent Synapses in Single Neuron Cultures

1998 • 138 citations

NMDA receptor activation limits the number of synaptic connections during hippocampal development

2001 • 136 citations

Differential roles for NSF and GRIP/ABP in AMPA receptor cycling

2002 • 134 citations

Transcriptional Regulation of the GluR2 Gene: Neural-Specific Expression, Multiple Promoters, and Regulatory Elements

1998 • 128 citations

Conditional Restoration of Hippocampal Synaptic Potentiation in GluR-A-Deficient Mice

2001 • 128 citations

Synaptic activation of AMPA receptors inhibits GABA release from cerebellar interneurons

2000 • 124 citations

Inhibition of the cAMP Pathway Decreases Early Long-Term Potentiation at CA1 Hippocampal Synapses

2000 • 122 citations

Surface Expression of GluR-D AMPA Receptor Is Dependent on an Interaction between Its C-Terminal Domain and a 4.1 Protein

2003 • 104 citations

SAP97 concentrates at the postsynaptic density in cerebral cortex

2000 • 100 citations

Neurotransmitter Receptor Dynamics Studied In Vivo by Reversible Photo-Unbinding of Fluorescent Ligands

2002 • 100 citations

Transcriptional regulation of the GluR2 gene: Neural-specific expression, multiple promoters, and regulatory elements

1998 • 97 citations

Modulation of AMPA/kainate receptors in cultured murine hippocampal neurones by protein kinase C.

1994 • 97 citations

Acute versus chronic NMDA receptor blockade and synaptic AMPA receptor delivery

2002 • 97 citations

A Labile Component of AMPA Receptor-Mediated Synaptic Transmission Is Dependent on Microtubule Motors, Actin, andN-Ethylmaleimide-Sensitive Factor

2001 • 95 citations

Oligomerization and Ligand-binding Properties of the Ectodomain of the α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunit GluRD

1999 • 95 citations

Changes in the subcellular distribution of calmodulin-kinase II during brain development

1985 • 94 citations

Effects of PKA and PKC on Miniature Excitatory Postsynaptic Currents in CA1 Pyramidal Cells

1998 • 92 citations

Distinct Roles for Ionotropic and Metabotropic Glutamate Receptors in the Maturation of Excitatory Synapses

2000 • 91 citations

Selective Binding of Synapse-associated Protein 97 to GluR-A α-Amino-5-hydroxy-3-methyl-4-isoxazole Propionate Receptor Subunit Is Determined by a Novel Sequence Motif

2002 • 91 citations

Differential palmitoylation of two mouse glutamate receptor interacting protein 1 forms with different N-terminal sequences

2001 • 69 citations

Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1

2002 • 69 citations

Biochemical and morphological characterization of an intracellular membrane compartment containing AMPA receptors

2001 • 69 citations

Stargazin Differentially Controls the Trafficking of α-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and Kainate Receptors

2003 • 68 citations

Differing Mechanisms for Glutamate Receptor Aggregation on Dendritic Spines and Shafts in Cultured Hippocampal Neurons

2002 • 54 citations

Critical Postsynaptic Density 95/Disc Large/Zonula Occludens-1 Interactions by Glutamate Receptor 1 (GluR1) and GluR2 Required at Different Subcellular Sites

2002 • 54 citations

Functional Organization of the GluR1 Glutamate Receptor Promoter

2001 • 50 citations

Modeling of the Pore Domain of the GLUR1 Channel: Homology with K+ Channel and Binding of Channel Blockers

2002 • 50 citations

Regulated delivery of AMPA receptor subunits to the presynaptic membrane

2003 • 48 citations

Mechanisms of Potentiation by Calcium-Calmodulin Kinase II of Postsynaptic Sensitivity in Rat Hippocampal CA1 Neurons

1997 • 47 citations

Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97

2002 • 29 citations

ABP: A Novel AMPA Receptor Binding Protein

1999 • 21 citations

Deleted Work

1955 • 0 citations