Mutational analysis of the cAMP-dependent protein kinase-mediated phosphorylation site of Rap1b.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

ras GENES

1987 • 3,818 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1991 • 1,327 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase.

1977 • 844 citations

The structure of an antigenic determinant in a protein

1984 • 841 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

1988 • 334 citations

Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product

1990 • 254 citations

Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1

1991 • 245 citations

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

1991 • 202 citations

Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins.

1990 • 154 citations

Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine.

1990 • 151 citations

A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets.

1989 • 141 citations

Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex.

1991 • 128 citations

Phorbol ester- and protein kinase C-mediated phosphorylation of the cellular Kirsten ras gene product.

1987 • 128 citations

Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations.

1990 • 125 citations

Purification and Characterization from Bovine Brain Cytosol of Two Gtpase-Activating Proteins Specific for smg p21, a GTP-binding Protein Having the Same Effector Domain as c-ras p21s

1989 • 120 citations

Identification of Small Clusters of Divergent Amino Acids that Mediate the Opposing Effects of ras and K rev -1

1990 • 114 citations

Phosphorylation of smg p21, a ras p21-like GTP-binding Protein, by Cyclic AMP-dependent Protein Kinase in a Cell-free System and in Response to Prostaglandin E1 in Intact Human Platelets

1989 • 110 citations

Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.

1991 • 110 citations

Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s.

1990 • 105 citations

Enhancement of the actions of smg p21 GDP/GTP exchange protein by the protein kinase A-catalyzed phosphorylation of smg p21.

1991 • 102 citations

Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells.

1991 • 96 citations

Rap1-b is phosphorylated by protein kinase a in intact human platelets

1990 • 90 citations

Phosphorylation by cyclic AMP-dependent protein kinase of a human platelet Mr 22,000 GTP-binding protein (smg p21) having the same putative effector domain as the ras gene products

1988 • 88 citations

RAP2B: a RAS-related GTP-binding protein from platelets.

1990 • 71 citations

Role of rap1B and p21ras GTPase-activating protein in the regulation of phospholipase C-gamma 1 in human platelets.

1992 • 68 citations

Phosphorylation of a Ras-related GTP-binding protein, Rap-1b, by a neuronal Ca2+/calmodulin-dependent protein kinase, CaM kinase Gr.

1991 • 62 citations

The cAMP-dependent protein kinase phosphorylates the rap1 protein in vitro as well as in intact fibroblasts, but not the closely related rap2 protein

1991 • 60 citations

Guanine nucleotide binding properties of rap1 purified from human neutrophils

1990 • 53 citations

Effect of protein kinase A on inositide metabolism and rap 1 G-protein in human erythroleukemia cells.

1990 • 47 citations

Phosphorylation of ras oncogene product by protein kinase C

1987 • 45 citations

Phosphorylation of the RAS2 gene product by protein kinase A inhibits the activation of yeast adenylyl cyclase.

1988 • 42 citations

Inhibition of the action of the stimulatory GDP/GTP exchange protein for smg p21 by the geranylgeranylated synthetic peptides designed from its C-terminal region.

1991 • 40 citations

The smg GDS-induced activation of smg p21 is initiated by cyclic AMP-dependent protein kinase-catalyzed phosphorylation of smg p21

1991 • 27 citations

Novel phosphorylation of c-ras p21 by protein kinases.

1988 • 25 citations

Phosphorylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae.

1989 • 25 citations

Antisera specific for rap 1 proteins distinguish between processed and nonprocessed rap 1b

1991 • 18 citations