Identification of Small Clusters of Divergent Amino Acids that Mediate the Opposing Effects of ras and K rev -1

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

ras GENES

1987 • 3,818 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

ras GTPase activating protein: Signal transmitter and signal terminator

1989 • 621 citations

Inhibition of restriction endonuclease Nel I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis

1986 • 560 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

Tumor Suppressor Genes: The Puzzle and the Promise

1989 • 488 citations

A novel ras-related gene family

1985 • 487 citations

The Approaching Era of the Tumor Suppressor Genes

1987 • 468 citations

Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library.

1987 • 403 citations

Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

1988 • 334 citations

Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21.

1986 • 291 citations

Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus

1982 • 272 citations

The ral gene: a new ras related gene isolated by the use of a synthetic probe.

1986 • 264 citations

Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes

1987 • 216 citations

When the products of oncogenes and anti-oncogenes meet

1989 • 213 citations

Mutational analysis of a ras catalytic domain.

1986 • 205 citations

The ras oncogene--an important regulatory element in lower eucaryotic organisms

1989 • 189 citations

A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. Purification, determination of primary structure, and characterization.

1988 • 185 citations

Carboxyl Rerminal Domain of G _sα Specifies Coupling of Receptors to Stimulation of Adenylyl Cyclase

1988 • 174 citations

Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations.

1990 • 125 citations

A structure and some function

1988 • 39 citations

Chimeric proteins define variable and essential regions of Ha-ras-encoded protein.

1988 • 31 citations

An altered DNA sequence encompassing therasgene of Harvey marine sarcoma virus

1984 • 16 citations