Ricin A chain utilises the endoplasmic reticulum‐associated protein degradation pathway to enter the cytosol of yeast

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

1987 • 1,153 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway

1996 • 704 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1997 • 556 citations

ER Quality Control: The Cytoplasmic Connection

1997 • 528 citations

Ricin: structure, mode of action, and some current applications

1994 • 469 citations

Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

1996 • 451 citations

S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase

1993 • 422 citations

Overview of N- and O-linked oligosaccharide structures found in various yeast species

1999 • 420 citations

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

1997 • 412 citations

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

1996 • 400 citations

Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast.

1996 • 385 citations

A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum

1993 • 326 citations

Accumulating Evidence Suggests That Several AB-Toxins Subvert the Endoplasmic Reticulum-Associated Protein Degradation Pathway To Enter Target Cells

1997 • 316 citations

Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.

1996 • 273 citations

Resistance to cadmium mediated by ubiquitin-dependent proteolysis

1993 • 261 citations

Endoplasmic reticulum degradation: reverse protein flow of no return

1997 • 256 citations

Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells.

1976 • 238 citations

Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol

1997 • 227 citations

Immunotoxins: magic bullets or misguided missiles?

1993 • 209 citations

Retrograde Transport of KDEL-bearing B-fragment of Shiga Toxin

1997 • 200 citations

ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together

1997 • 190 citations

Toxin Entry: Retrograde Transport through the Secretory Pathway

1998 • 186 citations

Protein-disulfide Isomerase-mediated Reduction of the A Subunit of Cholera Toxin in a Human Intestinal Cell Line

1997 • 117 citations

Toxin entry: how reversible is the secretory pathway?

1992 • 107 citations

Degradation of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Endoplasmic Reticulum Membranes Is Accelerated as a Result of Increased Susceptibility to Proteolysis

1996 • 104 citations

Peptides Glycosylated in the Endoplasmic Reticulum of Yeast Are Subsequently Deglycosylated by a Soluble Peptide: N-Glycanase Activity

1998 • 91 citations

Reduction of protein disulfide bonds in an oxidizing environment

1997 • 80 citations

Distinct processes mediate glycoprotein and glycopeptide export from the endoplasmic reticulum in Saccharomyces cerevisiae.

1992 • 52 citations

Mutagenesis and kinetic analysis of the active site Glu177 of ricin A-chain

1993 • 44 citations

Similar processes mediate glycopeptide export from the endoplasmic reticulum in mammalian cells and Saccharomyces cerevisiae

1997 • 42 citations

Ricin A Chain Fused to a Chloroplast-targeting Signal Is Unfolded on the Chloroplast Surface Prior to Import across the Envelope Membranes

1996 • 42 citations

Protein degradation: Go outside and see the proteasome

1996 • 34 citations

Free Ricin A Chain Reaches an Early Compartment of the Secretory Pathway before It Enters the Cytosol

1996 • 16 citations