Dopamine and reward: The anhedonia hypothesis 30 years on

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Dopamine, learning and motivation

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Opioids excite dopamine neurons by hyperpolarization of local interneurons

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Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System

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Responses of monkey dopamine neurons during learning of behavioral reactions

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Amphetamines and related compounds

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Brain Reward Circuitry

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A cellular mechanism of reward-related learning

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Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia

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Catecholamine theories of reward: A critical review

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Adenosine receptors and behavioral actions of methylxanthines.

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Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters†

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Neuroleptic-Induced "Anhedonia" in Rats: Pimozide Blocks Reward Quality of Food

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On the Presence of 3-Hydroxytyramine in Brain

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Lectures on Conditioned Reflexes.

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The taste reactivity test. II. Mimetic responses to gustatory stimuli in chronic thalamic and chronic decerebrate rats

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Increased Lever Pressing for Amphetamine After Pimozide in Rats: Implications for a Dopamine Theory of Reward

1975 • 536 citations

Behavioral functions of nucleus accumbens dopamine: Empirical and conceptual problems with the anhedonia hypothesis

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Approach‐avoidance analysis of rat diencephalon

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Intracranial self-administration of morphine into the ventral tegmental area in rats

1981 • 497 citations

The Neurobiology of Dopamine

1980 • 496 citations

Cortical Dopaminergic Involvement in Cocaine Reinforcement

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Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.

1977 • 490 citations

Morphine-induced activation of A10 dopamine neurons in the rat

1983 • 485 citations

Variables That Affect the Clinical Use and Abuse of Methylphenidate in the Treatment of ADHD

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Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine

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Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure

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Electrophysiological evidence for excitation of rat ventral tegmental area dopamine neurons by morphine

1984 • 424 citations

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Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats

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Adenosine A2A receptors and basal ganglia physiology

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Dopaminergic control of synaptic plasticity in the dorsal striatum

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A portrait of the substrate for self-stimulation.

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Reinforcing effects of morphine microinjection into the ventral tegmental area

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Two Types of Conditioned Reflex: A Reply to Konorski and Miller

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Self-administration of d-amphetamine by rats

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Pleasure Centers in the Brain

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Dopaminergic Mechanisms in Actions and Habits: Figure 1.

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Drug reinstatement of heroin-reinforced responding in the rat

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New Directions in Psychology

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Intracranial self-stimulation in relation to the ascending dopaminergic systems of the midbrain: A moveable electrode mapping study

1980 • 258 citations

A map of the rat mesencephalon for electrical self-stimulation

1972 • 252 citations

PLEASURE AND BRAIN ACTIVITY IN MAN

1972 • 249 citations

The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving

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Distinguishing Whether Dopamine Regulates Liking, Wanting, and/or Learning About Rewards.

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Neuroleptic-induced attenuation of brain stimulation reward in rats.

1978 • 229 citations

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Intracranial self-stimulation with electrodes in the region of the locus coeruleus

1972 • 215 citations

Dopaminergic and Noradrenergic Substrates of Positive Reinforcement: Differential Effects of d - and l -Amphetamine

1973 • 197 citations

High Dose Pimozide Does Not Block Amphetamine-Induced Euphoria in Normal Volunteers

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Animal Models of Parkinsonism Using Selective Neurotoxins: Clinical and Basic Implications

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The Neuropharmacological Basis of Reward

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Parametric analysis of brain stimulation reward in the rat: III. Effect of performance variables on the reward summation function.

1974 • 192 citations

Involvement of the Olfactory Tubercle in Cocaine Reward: Intracranial Self-Administration Studies

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Effects on homeostasis of intraventricular injections of 6-hydroxydopamine in rats.

1974 • 187 citations

Pimozide-induced extinction in rats: Stimulus control of responding rules out motor deficit

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Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats

1990 • 179 citations

Evidence implicating descending fibers in self-stimulation of the medial forebrain bundle

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Catecholamines and self-stimulation: Reward and performance effects dissociated

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Habit-forming actions of nomifensine in nucleus accumbens

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The anhedonia hypothesis: Mark III

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DISCUSSION PAPER: INNATE, DISCRIMINATIVE HUMAN FACIAL EXPRESSIONS TO TASTE AND SMELL STIMULATION

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Reward or reinforcement: What's the difference?

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Glucose- and fructose-conditioned flavor preferences in rats: Taste versus postingestive conditioning

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Facilitation of Brain Self-Stimulation by Central Administration of Norepinephrine

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Pimozide and amphetamine have opposing effects on the reward summation function

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Pimozide Does Not Shift Palatability: Separation of Anhedonia from Sensorimotor Suppression by Taste Reactivity

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Effects and Interactions of Imipramine, Chlorpromazine, Reserpine and Amphetamine on Self-Stimulation: Possible Neurophysiological Basis of Depression

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Clinical trials with amphetamine-blocking drugs.

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Intracranial Self-Stimulation in Man

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Role of noradrenergic and dopaminergic processes in amphetamine self-administration

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Reinforcement as consolidation.

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Blockade of intravenous amphetamine euphoria in man

1971 • 140 citations

Neuropharmacological assessment of cocaine self-administration into the medial prefrontal cortex

1986 • 136 citations

Resistance to satiation

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Effects of dopamine receptor blockade on alimentary behaviors: Home cage food consumption, magazine training, operant acquisition, and performance

1979 • 128 citations

Mechanism of action of cocaine and amphetamine in the brain

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Intracranial self-stimulation in relation to the ascending noradrenergic fiber systems of the pontine tegmentum and caudal midbrain: A moveable electrode mapping study

1979 • 118 citations

The Psychobiology of Reinforcers

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Does pimozide block the reinforcing effect of brain stimulation?

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Pimozide-induced suppression of responding: Evidence against a block of food reward

1980 • 117 citations

Effects of chlorpromazine, meprobamate, pentobarbital and morphine on self-stimulation.

1960 • 116 citations

Subjective responses to d-amphetamine alone and after pimozide pretreatment in normal, healthy volunteers

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A comparison of benzodiazepine, serotonin, and dopamine agents in the taste-reactivity paradigm

1990 • 108 citations

Haloperidol induces a partial reinforcement extinction effect in rats: Implications for a dopamine involvement in food reward

1986 • 106 citations

Separation of inhibiting and stimulating effects of morphine on self-stimulation behaviour by intracerebral microinjections

1976 • 106 citations

Intracranial Self-Stimulation and Wakefulness: Effect of Manipulating Ambient Brain Catecholamines

1970 • 104 citations

Partial reinforcement: A selective review of the alleyway literature since 1960.

1971 • 102 citations

A rapid, simple and sensitive method for the demonstration of central catecholamine-containing neurons and axons by glyoxylic acid-induced fluorescence. II. A detailed description of methodology.

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Intravenous self-administration of cocaine and norcocaine by dogs

1980 • 100 citations

Pimozide attenuates acquisition of lever-pressing for food in rats

1981 • 99 citations

Blockade of D1 Dopamine Receptors in the Ventral Tegmental Area Decreases Cocaine Reward: Possible Role for Dendritically Released Dopamine

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Drug-induced reinstatement of amphetamine self-administration behaviour in monkeys.

1973 • 97 citations

Crossroads of Limbic and Striatal Circuitry: Hypothalamo-Nigral Connections

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Pimozide attenuates free feeding: Best scores analysis reveals a motivational deficit

1984 • 93 citations

Localized intracaudate dopamine D2 receptor activation during the post-training period improves memory for visual or olfactory conditioned emotional responses in rats

1991 • 92 citations

Haloperidol differentially affects reinforcement and motivational processes in rats running an alley for intravenous heroin

1995 • 83 citations

Excitability properties of medial forebrain bundle axons of A9 and A10 dopamine cells

1988 • 82 citations

Isohedonic Tastes Support a Two-dimensional Hypothesis of Palatability

1984 • 82 citations

Dorsal noradrenergic bundle lesions fail to disrupt self-stimulation from the region of locus coeruleus

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Drive Decay: The Cause of Fast "Extinction" of Habits Learned for Brain Stimulation

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Effects of naloxone and pimozide on initiation and maintenance measures of free feeding

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A RAPID, SIMPLE AND SENSITIVE METHOD FOR THE DEMONSTRATION OF CENTRAL CATECHOLAMINE-CONTAINING NEURONS AND AXONS BY GLYOXYLIC ACID-INDUCED FLUORESCENCE

1976 • 63 citations

A partial reinforcement extinction effect in water-reinforced rats intermittently treated with haloperidol

1986 • 62 citations

Some effects of pimozide on nondeprived rats licking sucrose solutions in an anhedonia paradigm

1984 • 62 citations

Intracranial self-stimulation: mapping against the lateral boundaries of the dopaminergic cells of the substantia nigra

1981 • 60 citations

The human gustofacial response : observation on normal and anencephalic newborn infants

1973 • 48 citations

Haloperidol does not affect motivational processes in an operant runway model of food-seeking behavior.

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Haloperidol does not affect motivational processes in an operant runway model of food-seeking behavior.

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The dopamine anhedonia hypothesis: A pharmacological phrenology

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Chlorpromazine in nonpsychotic patients with pulmonary tuberculosis.

1960 • 29 citations

DEPTH‐ELECTROGRAPHIC OBSERVATIONS IN PSYCHOTIC PATIENTS

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Neuroleptics and Psychic Indifference: A Review

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Blockade of substantia nigra dopamine D1 receptors reduces intravenous cocaine reward in rats

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Addiction to pleasure: a biological and social-psychological theory of addiction.

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Moveable electrode for chronic brain stimulation in the rat

1976 • 19 citations

Caffeine restores feeding response to 2-deoxy-D-glucose in 6-hydroxydopamine-treated rats

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Neurolepsis: Anhedonia or blunting of emotional reactivity?

1982 • 13 citations

Hedonic arousal, memory, and motivation

1982 • 13 citations

Modelling drug kinetics with brain stimulation: Dopamine antagonists increase self-stimulation

1992 • 11 citations

Criteria for ruling out sedation as an interpretation of neuroleptic effects

1982 • 10 citations

Understanding neuroleptics: From “anhedonia” to “neuroleptothesia”

1982 • 8 citations

Induction by Antipsychotics of “Win-Shift” in the Drug Discrimination Paradigm

2007 • 6 citations

A functional consideration of anatomical connections between the basal ganglia and the thalamus suggests that antipsychotic drugs inhibit the initiation of movement

1985 • 2 citations

Neuroleptic drugs may attenuate pleasure in the operant chamber, but in the schizophrenic's head they may simply reduce motivational arousal

1985 • 2 citations

Sedation-induced jumping?

1985 • 1 citations

Deleted Work

1955 • 0 citations