Regulation of cell growth by oxidized LDL

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein.

1995 • 945 citations

Minimally modified low density lipoprotein stimulates monocyte endothelial interactions.

1990 • 930 citations

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.

1984 • 826 citations

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

1990 • 785 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

1992 • 653 citations

Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.

1983 • 623 citations

Modulation of fibroblast proliferation by oxygen free radicals

1990 • 617 citations

Cytolytic and membrane-perturbing properties of lysophosphatidylcholine

1979 • 594 citations

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.

1984 • 547 citations

Lipoprotein oxidation and lipoprotein-induced cytotoxicity.

1983 • 545 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture

1979 • 512 citations

Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.

1991 • 406 citations

Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications

1987 • 400 citations

Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium.

1992 • 357 citations

Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein.

1994 • 334 citations

Macrophage and smooth muscle cell proliferation in atherosclerotic lesions of WHHL and comparably hypercholesterolemic fat-fed rabbits.

1990 • 333 citations

Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells.

1994 • 332 citations

Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells.

1995 • 311 citations

Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-).

1994 • 280 citations

Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity.

1989 • 265 citations

Intact human ceruloplasmin oxidatively modifies low density lipoprotein.

1994 • 265 citations

Sphingolipids in Atherosclerosis and Vascular Biology

1998 • 242 citations

Injury to human endothelial cells in culture induced by low density lipoproteins

1979 • 231 citations

Oxidized LDL activates fas-mediated endothelial cell apoptosis.

1998 • 230 citations

Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells.

1994 • 230 citations

Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.

1991 • 216 citations

7 beta-hydroperoxycholest-5-en-3 beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein.

1994 • 208 citations

Sphingosine‐1‐Phosphate in Cell Growth and Cell Death^a

1998 • 202 citations

Redox-regulated Signaling by Lactosylceramide in the Proliferation of Human Aortic Smooth Muscle Cells

1997 • 202 citations

Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages.

1994 • 196 citations

Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol.

1994 • 190 citations

Inflammatory Platelet-activating Factor-like Phospholipids in Oxidized Low Density Lipoproteins Are Fragmented Alkyl Phosphatidylcholines

1999 • 186 citations

Heparin-binding EGF-like growth factor

1997 • 172 citations

The Oxidation of Lipoproteins by Monocytes-Macrophages

1999 • 172 citations

Native and oxidized LDL enhances production of PDGF AA and the surface expression of PDGF receptors in cultured human smooth muscle cells.

1992 • 169 citations

Oxidized LDL induces monocytic cell expression of interleukin-8, a chemokine with T-lymphocyte chemotactic activity.

1994 • 161 citations

Induction of interleukin 1 beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid.

1992 • 158 citations

Role of Sphingosine 1-Phosphate in the Mitogenesis Induced by Oxidized Low Density Lipoprotein in Smooth Muscle Cells via Activation of Sphingomyelinase, Ceramidase, and Sphingosine Kinase

1999 • 157 citations

Oxidized LDL Stimulates Mitogen-Activated Protein Kinases in Smooth Muscle Cells and Macrophages

1997 • 153 citations

Active proliferation of different cell types, including lymphocytes, in human atherosclerotic plaques.

1995 • 152 citations

Induction of Macrophage VEGF in Response to Oxidized LDL and VEGF Accumulation in Human Atherosclerotic Lesions

1998 • 151 citations

Oxidized low density lipoprotein suppresses the expression of tumor necrosis factor-alpha mRNA in stimulated murine peritoneal macrophages.

1990 • 150 citations

Induction of Rat Aortic Smooth Muscle Cell Growth by the Lipid Peroxidation Product 4-Hydroxy-2-Nonenal

1998 • 149 citations

Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells.

1995 • 143 citations

Oxidized Low Density Lipoprotein and Lysophosphatidylcholine Stimulate Cell Cycle Entry in Vascular Smooth Muscle Cells

1996 • 142 citations

Lysophosphatidylcholine increases vascular superoxide anion production via protein kinase C activation.

1994 • 139 citations

Lysophosphatidylcholine upregulates the level of heparin-binding epidermal growth factor-like growth factor mRNA in human monocytes.

1994 • 138 citations

Multiple lipid oxidation products in low density lipoproteins induce interleukin-1 beta release from human blood mononuclear cells.

1994 • 129 citations

Elevated Tissue Factor and Tissue Factor Pathway Inhibitor Circulating Levels in Ischaemic Heart Disease Patients

1998 • 126 citations

Cell Proliferation and Oxidative Stress

1989 • 124 citations

Lipoxygenase-mediated transformation of human low density lipoprotein to an oxidized and cytotoxic complex.

1991 • 123 citations

Induction of murine macrophage growth by modified LDLs.

1993 • 121 citations

Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: Implications with respect to macrophage recognition of apoptotic cells

1999 • 121 citations

Stimulation of proliferation in stationary primary cultures of monkey and rabbit aortic smooth muscle cells

1976 • 120 citations

Necrosis and apoptosis induced by oxidized low density lipoproteins occur through two calcium‐dependent pathways in lymphoblastoid cells

1994 • 120 citations

The Sphingomyelin-Ceramide Signaling Pathway Is Involved in Oxidized Low Density Lipoprotein-induced Cell Proliferation

1996 • 119 citations

Characterization of endothelial cell injury by cholesterol oxidation products found in oxidized LDL.

1995 • 113 citations

In vitro cell injury by oxidized low density lipoprotein involves lipid hydroperoxide-induced formation of alkoxyl, lipid, and peroxyl radicals.

1995 • 112 citations

Toxicity of oxidized low‐density lipoprotein to cultured fibroblasts is selective for S phase of the cell cycle

1987 • 112 citations

Deletion of the membrane anchoring region of tissue factor abolishes autoactivation of factor VII but not cofactor function. Analysis of a mutant with a selective deficiency in activity.

1992 • 111 citations

Role of oxidized human plasma low density lipoproteins in atherosclerosis: effects on smooth muscle cell proliferation

1992 • 106 citations

Two Intracellular Signaling Pathways for Activation of Protein Kinase C Are Involved in Oxidized Low-Density Lipoprotein–Induced Macrophage Growth

1997 • 103 citations

The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages

1991 • 102 citations

The Scavenger Receptor Serves as a Route for Internalization of Lysophosphatidylcholine in Oxidized Low Density Lipoprotein-induced Macrophage Proliferation

1996 • 100 citations

Roles of multiple oxidized LDL lipids in cellular injury: dominance of 7 beta-hydroperoxycholesterol

1996 • 100 citations

Oxidation of low density lipoprotein by mesangial cells may promote glomerular injury

1994 • 98 citations

Tissue-factor pathway inhibitor and lipoproteins. Evidence for association with and regulation by LDL in human plasma.

1994 • 95 citations

Human atherosclerosis. IV. Immunocytochemical analysis of cell activation and proliferation in lesions of young adults.

1993 • 91 citations

Effect of alpha-tocopherol on restenosis after angioplasty in a model of experimental atherosclerosis.

1995 • 90 citations

Lipoprotein-mediated inhibition of endothelial cell production of platelet-derived growth factor-like protein depends on free radical lipid peroxidation.

1987 • 87 citations

Exogenous Oxidized Low-Density Lipoprotein Injures and Alters the Barrier Function of Endothelium in Rats In Vivo

1997 • 85 citations

Phosphatidylinositol 3-Kinase Is Involved in the Induction of Macrophage Growth by Oxidized Low Density Lipoprotein

1998 • 84 citations

Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. II. Uptake and cytotoxicity of ultraviolet-treated LDL on lymphoid cell lines

1990 • 84 citations

HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein

1997 • 84 citations

Proliferative and cytotoxic effects of mildly oxidized low-density lipoproteins on vascular smooth-muscle cells

1995 • 84 citations

Induction of apoptosis and of interleukin‐1β secretion by 7β‐hydroxycholesterol and 7‐ketocholesterol: partial inhibition by Bcl‐2 overexpression

1997 • 83 citations

Modified low density lipoproteins activate human macrophages to secrete immunoreactive endothelin

1991 • 83 citations

Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. III. The protective effect of antioxidants (probucol, catechin, vitamin E) against the cytotoxicity of oxidized LDL occurs in two different ways

1991 • 82 citations

Potential Role for Ceramide in Mitogen-activated Protein Kinase Activation and Proliferation of Vascular Smooth Muscle Cells Induced by Oxidized Low Density Lipoprotein

1998 • 80 citations

Thromboxane A2 stimulates vascular smooth muscle hypertrophy by up-regulating the synthesis and release of endogenous basic fibroblast growth factor

1993 • 79 citations

Activation of ICAM-1 promoter by lysophosphatidylcholine: Possible involvement of protein tyrosine kinases

1997 • 79 citations

Active Oxygen Species and Lysophosphatidylcholine Are Involved in Oxidized Low Density Lipoprotein Activation of Smooth Muscle Cell DNA Synthesis

1996 • 78 citations

Lysophosphatidylcholine Potentiates the Mitogenic Activity of Modified LDL for Human Monocyte–Derived Macrophages

1996 • 75 citations

Lactosylceramide Stimulates Ras-GTP Loading, Kinases (MEK, Raf), p44 Mitogen-activated Protein Kinase, and c-fos Expression in Human Aortic Smooth Muscle Cells

1996 • 75 citations

Cytotoxicity of oxidized low‐density lipoprotein to mouse peritoneal macrophages: An ultrastructural study

1993 • 73 citations

Induction of Murine Macrophage Growth by Oxidized Low Density Lipoprotein Is Mediated by Granulocyte Macrophage Colony-stimulating Factor

1998 • 72 citations

Effect of lipoproteins on mesangial cell proliferation

1999 • 69 citations

Lysophosphatidylcholine causes Ca2+ influx, enhanced DNA synthesis and cytotoxicity in cultured vascular smooth muscle cells

1995 • 68 citations

The mitogenic effect of H₂O₂ for vascular smooth muscle cells is mediated by an increase of the affinity of basic fibroblast growth factor for its receptor

1996 • 67 citations

Oxidized low density lipoprotein stimulates aortic smooth muscle cell proliferation

1996 • 65 citations

Suppression of endothelin-1 secretion by lysophosphatidylcholine in oxidized low density lipoprotein in cultured vascular endothelial cells.

1992 • 61 citations

Injury to cultured endothelial cells induced by low density lipoproteins: protection by high density lipoproteins

1979 • 60 citations

Induction of macrophage growth by advanced glycation end products of the Maillard reaction.

1994 • 59 citations

Oxidized low density lipoproteins stimulate galactosyltransferase activity, ras activation, p⁴⁴ mitogen activated protein kinase and c-fos expression in aortic smooth muscle cells

1997 • 57 citations

Oxidized low density lipoprotein caused CNS neuron cell death

1997 • 57 citations

Oxidized LDL Mediates the Release of Fibroblast Growth Factor-1

1997 • 57 citations

Lactosylceramide stimulates aortic smooth muscle cell proliferation

1991 • 56 citations

Stimulation of mitogen activated protein kinase by LDL and oxLDL in human U‐937 macrophage‐like cells

1996 • 55 citations

Effect of lipoproteins on cultured human mesangial cells

1997 • 50 citations

A Modification of Apolipoprotein B Accounts for Most of the Induction of Macrophage Growth by Oxidized Low Density Lipoprotein

1999 • 50 citations

Swine aortic smooth muscle in tissue culture. Some effects of purified swine lipoproteins on cell growth and morphology.

1976 • 50 citations

Induction of basic fibroblast growth factor mRNA and protein synthesis in smooth muscle cells by cholesteryl ester enrichment and 25-hydroxycholesterol.

1993 • 49 citations

Lysophosphatidylcholine Regulates Cationic Amino Acid Transport and Metabolism in Vascular Smooth Muscle Cells

1997 • 47 citations

Cytotoxicity of oxidized lipoproteins

1991 • 47 citations

Inhibition of lymphocyte mitogenesis by autoxidized low-density lipoprotein

1978 • 46 citations

Inhibitors of protein and RNA synthesis block the cytotoxic effects of oxygenated sterols

1992 • 44 citations

Induction of platelet-derived growth factor chain a gene expression in human smooth muscle cells by oxidized low density lipoproteins

1992 • 41 citations

Novel cardiovascular actions of the activins

1999 • 34 citations

Oxidized LDL modulates activation of NFκB in mononuclear phagocytes by altering the degradation of IκBs

1998 • 31 citations

Glucocorticoid Inhibits Oxidized LDL-Induced Macrophage Growth by Suppressing the Expression of Granulocyte/Macrophage Colony-Stimulating Factor

1999 • 31 citations

Effects of oxidized low density lipoprotein on endothelin secretion by cultured endothelial cells and macrophages

1996 • 28 citations

Effect of lipoprotein on in vitro synthesis of DNA in aortic tissue

1977 • 25 citations

Atherogenic lipoproteins stimulate mesangial cell p42 mitogen-activated protein kinase.

1998 • 23 citations

Relationship of molecular structure to the mechanism of lysophospholipid-induced smooth muscle cell proliferation

2000 • 22 citations

Minimally modified low density lipoproteins induce aortic smooth muscle cell proliferation via the activation of mitogen activated protein kinase.

1997 • 19 citations

Oxidized Low Density Lipoprotein Stimulates Protein Kinase C (PKC) Activity and Expression of PKC-Isotypes via Prostaglandin-H-Synthase in P388D1 Cells

1997 • 18 citations

Atherogenic lipoproteins enhance mesangial cell expression of platelet-derived growth factor: Role of protein tyrosine kinase and cyclic amp-dependent protein kinase A

1998 • 15 citations

Injury to human cells in culture induced by low density lipoprotein: An effect independent of receptor binding and endocytotic uptake of low density lipoprotein

1982 • 14 citations

Effects of Copper-Zinc Type Superoxide Dismutase on the Proliferation and Migration of Cultured Vascular Smooth Muscle Cells Induced by Oxidized Low Density Lipoprotein

1997 • 14 citations

Injury to human cells in culture induced by low density lipoprotein: An effect independent of receptor binding and endocytotic uptake of low density lipoprotein

1982 • 14 citations

Oxidized LDL potentiates LPS-induced transcription of the chemokine KC gene

1996 • 9 citations

The Effect of LDL and Modified LDL on Macrophage Secretion Products

1984 • 3 citations

Effect of Lipoprotein on In Vitro Synthesis of DNA in Aortic Tissue

1977 • 2 citations

Tissue factor induced in rat smooth muscle cells by oxidized low density lipoprotein and lysophosphatidylcholine

1995 • 1 citations

Specificity and cellular mechanism of lysophosphatidylcholine stimulation of vascular smooth muscle cell growth.

1997 • 1 citations

Oxidized low density lipoprotein and lysophosphatidylcholine stimulation of DNA synthesis in vascular smooth muscle cells appears mediated by basic fibroblast growth factor.

1995 • 1 citations