7 beta-hydroperoxycholest-5-en-3 beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein.

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Beyond Cholesterol

1989 • 6,533 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.

1984 • 826 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Malondialdehyde-Altered Protein Occurs in Atheroma of Watanabe Heritable Hyperlipidemic Rabbits

1988 • 757 citations

Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.

1983 • 623 citations

Role of oxidatively modified LDL in atherosclerosis

1990 • 614 citations

Lipoprotein oxidation and lipoprotein-induced cytotoxicity.

1983 • 545 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture

1979 • 512 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications

1987 • 400 citations

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

1991 • 386 citations

Biological activities of oxysterols

1989 • 355 citations

Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-).

1994 • 280 citations

Oxygen-mediated heterogeneity of apo-low-density lipoprotein.

1978 • 276 citations

Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity.

1989 • 265 citations

Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit.

1989 • 250 citations

Injury to human endothelial cells in culture induced by low density lipoproteins

1979 • 231 citations

Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages.

1990 • 162 citations

Oxidized low density lipoprotein suppresses the expression of tumor necrosis factor-alpha mRNA in stimulated murine peritoneal macrophages.

1990 • 150 citations

Activated human monocytes oxidize low-density lipoprotein by a lipoxygenase-dependent pathway.

1990 • 132 citations

Lipoxygenase-mediated transformation of human low density lipoprotein to an oxidized and cytotoxic complex.

1991 • 123 citations

Oxidized low density lipoprotein inhibits the migration of aortic endothelial cells in vitro.

1993 • 115 citations

Toxicity of oxidized low‐density lipoprotein to cultured fibroblasts is selective for S phase of the cell cycle

1987 • 112 citations

Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. II. Uptake and cytotoxicity of ultraviolet-treated LDL on lymphoid cell lines

1990 • 84 citations

Uptake, metabolism, and cytotoxicity of isomeric cholesterol-5,6-epoxides in rabbit aortic endothelial cells.

1991 • 81 citations

Oxidation of cholesterol moiety of low density lipoprotein in the presence of human endothelial cells or Cu+2 ions: Identification of major products and their effects

1991 • 78 citations

A simple and sensitive method for monitoring drug-induced cell injury in cultured cells

1985 • 72 citations

Toxicity of oxygenated cholesterol derivatives toward cultured human umbilical vein endothelial cells.

1991 • 41 citations

Occurrence of cholesterol 7α- and 7β-hydroperoxides in rat skin as aging markers

1991 • 37 citations

Oxidation of 3‐oxygenated Δ⁴‐ and Δ⁵‐C₂₇ steroids by soybean lipoxygenase and rat liver microsomessteroids by soybean lipoxygenase and rat liver microsomes

1980 • 22 citations

Ultrastructural and functional abnormalities of intestinal and renal epithelium in the SHR

1990 • 18 citations

On the role of sterol hydroperoxides in steroid metabolism.

1972 • 5 citations