Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells.

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Beyond Cholesterol

1989 • 6,533 citations

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

The Role of Polyamines in the Neutralization of Bacteriophage Deoxyribonucleic Acid

1960 • 2,598 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT)

1986 • 1,758 citations

Is Relationship Between Serum Cholesterol and Risk of Premature Death From Coronary Heart Disease Continuous and Graded?

1986 • 1,248 citations

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

Epidemiology of coronary heart disease: The Framingham study

1984 • 1,072 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Rapid separation of lipid classes in high yield and purity using bonded phase columns.

1985 • 939 citations

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

1990 • 871 citations

High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein

1990 • 836 citations

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

1990 • 785 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis.

1988 • 655 citations

Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung

1991 • 594 citations

Preparative and quantitative isolation of plasma lipoproteins: rapid, single discontinuous density gradient ultracentrifugation in a vertical rotor.

1980 • 549 citations

Anti-inflammatory properties of a platelet-activating factor acetylhydrolase

1995 • 529 citations

Enhanced macrophage degradation of biologically modified low density lipoprotein.

1983 • 469 citations

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

1986 • 417 citations

Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein.

1995 • 412 citations

Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor.

1987 • 404 citations

Endothelial cell-associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion.

1990 • 391 citations

Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro.

1985 • 380 citations

The antioxidant butylated hydroxytoluene protects against atherosclerosis.

1991 • 362 citations

Human plasma platelet-activating factor acetylhydrolase. Purification and properties.

1987 • 335 citations

Human plasma platelet-activating factor acetylhydrolase. Oxidatively fragmented phospholipids as substrates

1991 • 308 citations

Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.

1991 • 300 citations

Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivatization of apolipoprotein B by products of fatty acid peroxidation

1989 • 294 citations

Role of oxidized low density lipoprotein in atherogenesis

1992 • 279 citations

Platelet-activating factor: a phospholipid autacoid with diverse actions

1993 • 253 citations

An Oxidized Derivative of Phosphatidylcholine is a Substrate for the Platelet-Activating Factor Acetylhydrolase from Human Plasma

1989 • 234 citations

Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor

1991 • 221 citations

Bovine aortic endothelial cells display macrophage-like properties towards acetylated 125I-labelled low density lipoprotein

1980 • 212 citations

Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine.

1992 • 207 citations

Lysophosphatidylcholine: Essential role in the inhibition of endothelium-dependent vasorelaxation by oxidized low density lipoprotein

1990 • 187 citations

Plasma cholesterol concentration and death from coronary heart disease: 10 year results of the Whitehall study.

1986 • 176 citations

Oxidized low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle.

1990 • 152 citations

Oxygen radicals inhibit human plasma acetylhydrolase, the enzyme that catabolizes platelet-activating factor.

1994 • 132 citations

Induction of Growth-related Metabolism in Human Vascular Smooth Muscle Cells by Low Density Lipoprotein

1989 • 131 citations

Novel leukocyte agonists are released by endothelial cells exposed to peroxide.

1992 • 129 citations

Low density lipoprotein causes general cellular activation with increased phosphatidylinositol turnover and lipoprotein catabolism.

1988 • 116 citations

Attenuation of atherosclerosis in a modified strain of hypercholesterolemic Watanabe rabbits with use of a probucol analogue (MDL 29,311) that does not lower serum cholesterol.

1991 • 106 citations

Cellular oxidative modification of low density lipoprotein does not require lipoxygenases.

1992 • 101 citations

The platelet-activating factor acetylhydrolase from human plasma prevents oxidative modification of low-density lipoprotein.

1992 • 93 citations

Novel cellular activities for low density lipoprotein in vascular smooth muscle cells.

1990 • 66 citations

Preformed PAF‐acether and lyso PAF‐acether are bound to blood lipoproteins

1988 • 60 citations

Formation of platelet-activating factor-like phospholipids by Fe2+/ascorbate/EDTA-induced lipid peroxidation

1993 • 59 citations

Serum low density lipoproteins with mitogenic effect on cultured aortic smooth muscle cells

1982 • 55 citations

PAF-acether-degrading acetylhydrolase in plasma LDL is inactivated by copper- and cell-mediated oxidation.

1994 • 52 citations

Oxidation of low density lipoprotein enhances its potential to increase intracellular free calcium concentration in vascular smooth muscle cells.

1992 • 50 citations

Induction of platelet-derived growth factor chain a gene expression in human smooth muscle cells by oxidized low density lipoproteins

1992 • 41 citations

Interaction of platelet‐activating factor with endothelial and vascular smooth muscle cells in coculture

1989 • 39 citations

Oxidized low density lipoproteins stimulate phosphoinositide turnover in cultured vascular smooth muscle cells.

1992 • 36 citations

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

1986 • 36 citations

Lysolecithin actions on vascular smooth muscle cells

1992 • 31 citations

Increased growth stimulation of human vascular cells by serum from patients with primary hyper-LDL-cholesterolemia

1987 • 20 citations

[16] Quantitation of platelet-activating factor by gas chromatography-mass spectrometry

1990 • 19 citations

[Protective effect of high density lipoproteins, their subfractions and lecithin-cholesterol-acyltransferases on the peroxidation modification of low density lipoproteins].

1989 • 16 citations

Effect of low-density lipoprotein on intracellular calcium, intracellular pH and DNA synthesis in cultured vascular smooth muscle cells

1989 • 11 citations