Multiple lipid oxidation products in low density lipoproteins induce interleukin-1 beta release from human blood mononuclear cells.

Beyond Cholesterol

1989 • 6,533 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

[42] Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal

1990 • 3,220 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

Handbook of methods for oxygen radical research

1987 • 2,395 citations

The role of lipid peroxidation and antioxidants in oxidative modification of LDL

1992 • 2,335 citations

Quantitation of mRNA by the polymerase chain reaction.

1989 • 1,648 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein

1990 • 836 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein.

1991 • 739 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Localization of PDGF-B Protein in Macrophages in All Phases of Atherogenesis

1990 • 584 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation.

1991 • 477 citations

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

1986 • 417 citations

Presence of a modified low density lipoprotein in humans.

1988 • 373 citations

STUDIES ON THE ROLE OF LIPOPEROXIDES IN HUMAN PATHOLOGY

1952 • 347 citations

[11] Methods for investigating the essential groups for enzyme activity

1957 • 305 citations

Physiologic levels of ascorbate inhibit the oxidative modification of low density lipoprotein

1990 • 297 citations

Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivatization of apolipoprotein B by products of fatty acid peroxidation

1989 • 294 citations

Effect of Antioxidants on Oxidative Modification of LDL

1991 • 263 citations

Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit.

1989 • 250 citations

Minimally oxidized low-density lipoprotein induces tissue factor expression in cultured human endothelial cells.

1991 • 228 citations

Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification.

1991 • 228 citations

β-Carotene inhibits the oxidative modification of low-density lipoprotein

1991 • 227 citations

Macrophage-derived foam cells freshly isolated from rabbit atherosclerotic lesions degrade modified lipoproteins, promote oxidation of low-density lipoproteins, and contain oxidation-specific lipid-protein adducts.

1991 • 219 citations

Minimally modified low density lipoprotein is biologically active in vivo in mice.

1991 • 212 citations

Lipid hydroperoxide involvement in copper-dependent and independent oxidation of low density lipoproteins.

1991 • 177 citations

Release of IL-1 from mononuclear phagocytes.

1991 • 169 citations

Induction of interleukin 1 beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid.

1992 • 158 citations

Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein.

1990 • 153 citations

Oxidized low density lipoprotein suppresses the expression of tumor necrosis factor-alpha mRNA in stimulated murine peritoneal macrophages.

1990 • 150 citations

Autoxidation of polyunsaturated esters in water: chemical structure and biological activity of the products

1967 • 149 citations

Mixed Disulfides: Biological Functions and Increase in Oxidative Stress

1985 • 149 citations

Vitamin E and other Lipophilic Antioxidants Protect LDL against Oxidation

1989 • 134 citations

Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro: probucol degradation precedes lipoprotein oxidation.

1989 • 107 citations

Inhibition by probucol of interleukin 1 secretion and its implication in atherosclerosis

1988 • 99 citations

Lipids of human atheroma. 8. Oxidised derivatives of cholesteryl linoleate.

1973 • 95 citations

Inhibition of IL-1β expression in THP-1 cells by probucol and tocopherol

1991 • 94 citations

Inhibition of lipopolysaccharide-induced interleukin-1 beta mRNA expression in mouse macrophages by oxidized low density lipoprotein.

1991 • 85 citations

Role of leukotrienes in leukocyte adhesion following systemic administration of oxidatively modified human low density lipoprotein in hamsters.

1991 • 81 citations

The oxygenation of cholesterol esters by the reticulocyte lipoxygenase

1991 • 75 citations

Ex vivo lipopolysaccharide‐induced interleukiri‐1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant properties

1990 • 74 citations

Inhibition of protein synthesis by carbonyl compounds (4-hydroxyalkenals) originating from the peroxidation of liver microsomal lipids

1981 • 65 citations

Modification of copper-catalyzed oxidation of low density lipoprotein by proteoglycans and glycosaminoglycans.

1991 • 65 citations

Formation, reactions and toxicity of aldehydes produced in the course of lipid peroxidation in cellular membranes

1987 • 63 citations

Lipids of human atheroma: Isolation of hydroxyoctadecadienoic acids from advanced aortal lesions

1970 • 51 citations

High-performance liquid chromatography of linoleic acid hydroperoxides and their corresponding alcohol derivatives

1985 • 50 citations

Uptake and degradation of low density lipoproteins in atherosclerotic rabbit aorta: role of local LDL modification.

1991 • 43 citations

Involvement of Cyclic AMP-Dependent Protein Kinases in the Signal Transduction Pathway for Interleukin-1

1990 • 30 citations

Effect of isolated right ventricular outflow obstruction on left ventricular function in infants

1988 • 30 citations

Effect of interleukin-1 receptor antagonist on vascular smooth muscle cell proliferation

1993 • 24 citations

Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1.

1990 • 22 citations

Effects of oxidized low density lipoproteins on arachidonic acid metabolism in smooth muscle cells.

1990 • 22 citations

Isolation and Characterization of Plasma Lipoproteins and Apolipoproteins

1984 • 13 citations

Malondialdehyde, modified lipoproteins, and atherosclerosis

1990 • 12 citations