Sphingolipids in Atherosclerosis and Vascular Biology

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Low Density Lipoprotein Oxidation and Its Pathobiological Significance

1997 • 1,642 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

Free Radicals as Mediators of Tissue Injury and Disease

1993 • 1,480 citations

The Response-to-Retention Hypothesis of Early Atherogenesis

1995 • 1,365 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo

1997 • 751 citations

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.

1986 • 702 citations

ANIMAL GLYCOSPHINGOLIPIDS AS MEMBRANE ATTACHMENT SITES FOR BACTERIA

1989 • 686 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.

1983 • 623 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes

1995 • 538 citations

Oxidative mechanisms in carcinogenesis

1993 • 484 citations

An update of the enzymology and regulation of sphingomyelin metabolism

1990 • 460 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis

1997 • 428 citations

Functional Role of Glycosphingolipids in Cell Recognition and Signaling

1995 • 393 citations

Secretory Sphingomyelinase, a Product of the Acid Sphingomyelinase Gene, Can Hydrolyze Atherogenic Lipoproteins at Neutral pH

1998 • 313 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

Apoptosis induced in Burkitt's lymphoma cells via Gb3/CD77, a glycolipid antigen.

1993 • 235 citations

Stress-induced apoptosis and the sphingomyelin pathway

1997 • 234 citations

Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness.

1992 • 223 citations

Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx.

1994 • 220 citations

Sphingomyelin breakdown and cell fate

1996 • 212 citations

Redox-regulated Signaling by Lactosylceramide in the Proliferation of Human Aortic Smooth Muscle Cells

1997 • 202 citations

Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation.

1995 • 197 citations

Lipid accumulation in rabbit aortic intima 2 hours after bolus infusion of low density lipoprotein. A deep-etch and immunolocalization study of ultrarapidly frozen tissue.

1991 • 177 citations

A possible role of sphingosine in induction of apoptosis by tumor necrosis factor‐α, in human neutrophils

1994 • 168 citations

A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids.

1986 • 166 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Tumor Necrosis Factor-α Stimulates the Maturation of Sterol Regulatory Element Binding Protein-1 in Human Hepatocytes through the Action of Neutral Sphingomyelinase

1998 • 146 citations

Lipid biochemistry: functions of glycerolipids and sphingolipids in cellular signaling

1997 • 136 citations

Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase.

1998 • 132 citations

Glycolipids and transmembrane signaling: antibodies to galactocerebroside cause an influx of calcium in oligodendrocytes.

1990 • 131 citations

The separation of neutral blood-serum glycolipids by thin-layer chromatography

1963 • 130 citations

GM3 directly inhibits tyrosine phosphorylation and de-N-acetyl-GM3 directly enhances serine phosphorylation of epidermal growth factor receptor, independently of receptor-receptor interaction.

1994 • 128 citations

Reactive Oxygen Intermediates Mediate Angiotensin II-induced c-Jun•c-Fos Heterodimer DNA Binding Activity and Proliferative Hypertrophic Responses in Myogenic Cells

1995 • 122 citations

Distribution of glycosphingolipids in the serum lipoproteins of normal human subjects and patients with hypo- and hyperlipidemias

1976 • 113 citations

Lactosylceramide Mediates Tumor Necrosis Factor-α-induced Intercellular Adhesion Molecule-1 (ICAM-1) Expression and the Adhesion of Neutrophil in Human Umbilical Vein Endothelial Cells

1998 • 107 citations

Induction of Neonatal Tolerance to Mls^aAntigens by CD8⁺T Cells

1990 • 103 citations

An activation-collision mechanism for cholesterol transfer between membranes.

1988 • 99 citations

Isolation and Characterization of Ceramide Glycanase from the Leech, Macrobdella decora

1989 • 98 citations

Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances.

1993 • 97 citations

A specific cell surface glycoconjugate controlling cell motility: evidence by functional monoclonal antibodies that inhibit cell motility and tumor cell metastasis

1991 • 96 citations

Oxidants induce phosphorylation of ribosomal protein S6.

1988 • 91 citations

A low density lipoprotein-sized particle isolated from human atherosclerotic lesions is internalized by macrophages via a non-scavenger-receptor mechanism.

1990 • 87 citations

Accumulation of glycosphingolipids in human atherosclerotic plaque and unaffected aorta tissues

1997 • 86 citations

Ganglioside GM1 and asialo-GM1 at low concentration are preferentially incorporated into the gel phase in two-component, two-phase phosphatidylcholine bilayers

1991 • 84 citations

Lactosylceramide Stimulates Ras-GTP Loading, Kinases (MEK, Raf), p44 Mitogen-activated Protein Kinase, and c-fos Expression in Human Aortic Smooth Muscle Cells

1996 • 75 citations

Glycosphingolipid Accumulation in the Aortic Wall Is Another Feature of Human Atherosclerosis

1995 • 73 citations

Glucosylceramides stimulate murine epidermal hyperproliferation.

1995 • 70 citations

Role of lactosylceramide and MAP kinase in the proliferation of proximal tubular cells in human polycystic kidney disease.

1996 • 69 citations

Lactosylceramide Stimulates Human Neutrophils to Upregulate Mac-1, Adhere to Endothelium, and Generate Reactive Oxygen Metabolites In Vitro

1998 • 68 citations

Intracellular localization of lactosylceramide, the major human neutrophil glycosphingolipid.

1987 • 67 citations

Oxidized low density lipoprotein stimulates aortic smooth muscle cell proliferation

1996 • 65 citations

[Gaucher's disease].

1955 • 62 citations

The effect of cholesterol on the turnover of lecithin, cephalin and sphingomyelin in the rabbit

1956 • 62 citations

Oxidized low density lipoproteins stimulate galactosyltransferase activity, ras activation, p⁴⁴ mitogen activated protein kinase and c-fos expression in aortic smooth muscle cells

1997 • 57 citations

Lactosylceramide stimulates aortic smooth muscle cell proliferation

1991 • 56 citations

Glycosphingolipids of human plasma lipoproteins

1976 • 52 citations

Glucosphingolipid dependence of hormone-stimulated inositol trisphosphate formation.

1990 • 49 citations

Nitric oxide modulates signaling between cultured adult peripheral cardiac neurons and cardiomyocytes

1995 • 41 citations

Sphingolipids

1996 • 35 citations

Biosynthesis of the sphingoid bases: a provocation

1984 • 34 citations

Regulation of synthesis of lactosylceramide and long chain bases in normal and familial hypercholesterolemic cultured proximal tubular cells.

1986 • 32 citations

Localization of urinary lactosylceramide in cytoplasmic vesicles of renal tubular cells in homozygous familial hypercholesterolemia.

1983 • 29 citations

Biosynthesis and Regulation of Glycosphingolipids

1999 • 27 citations

Sphingomyelinase Activity in Human Platelets

1998 • 27 citations

Increased urinary excretion of glycosphingolipids in familial hypercholesterolemia.

1982 • 25 citations

Uptake and metabolism of lactosylceramide on low density lipoproteins in cultured proximal tubular cells from normal and familial hypercholesterolemic homozygotes.

1986 • 19 citations

Minimally modified low density lipoproteins induce aortic smooth muscle cell proliferation via the activation of mitogen activated protein kinase.

1997 • 19 citations

Regulation of glycosphingolipid glycosyltransferase by low density lipoprotein receptors in cultured human proximal tubular cells.

1988 • 19 citations

UDPgalactose:glucosylceramide β1 → 4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes

1987 • 18 citations

Down-regulation of a 67-kDa YIGSR-binding Protein upon Differentiation of Human Neuroblastoma Cells

1995 • 16 citations

Oxidized low density lipoproteins and lactosylceramide both stimulate the expression of proliferating cell nuclear antigen and the proliferation of aortic smooth muscle cells.

1997 • 15 citations

Regulation of synthesis of lactosylceramide in normal and tumor proximal tubular cells

1993 • 14 citations

Distribution of antithrombin III and glucosylceramide in human plasma lipoproteins and lipoprotein deficient plasma

1984 • 7 citations

Oxygen as a Remedial Agent

1872 • 5 citations

Phosphatidylcholine stimulates the activity of UDP-Gal beta 1-4 galactosyltransferase in normal human kidney proximal tumour cells.

1990 • 5 citations

Regulation of Lactosylceramide Biosynthesis: An Opportunity and a Challenge for Glycobiologists.

1994 • 2 citations

Role of low density lipoprotein receptors in the regulation of synthesis of lactosylceramide in cultured normal human proximal tubular cells.

1988 • 2 citations