The role of BTB domain-containing zinc finger proteins in T cell development and function

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

The lineage decisions of helper T cells

2002 • 1,678 citations

NFAT proteins: key regulators of T-cell development and function

2005 • 1,434 citations

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

2006 • 1,403 citations

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

2000 • 1,379 citations

Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

2000 • 1,188 citations

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

1997 • 921 citations

BCL-6 Represses Genes that Function in Lymphocyte Differentiation, Inflammation, and Cell Cycle Control

2000 • 862 citations

T-cell development and the CD4–CD8 lineage decision

2002 • 738 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells

2004 • 703 citations

Alterations of a Zinc Finger-Encoding Gene, BCL-6 , in Diffuse Large-Cell Lymphoma

1993 • 680 citations

Sequence and structural analysis of BTB domain proteins

2005 • 658 citations

The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

2004 • 650 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

Signaling and Transcription in T Helper Development

2000 • 635 citations

Subspecialization of Cxcr5+ T Cells

2001 • 590 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

1994 • 527 citations

Migratory Properties of Naive, Effector, and Memory Cd8+ T Cells

2001 • 514 citations

BCoR, a novel corepressor involved in BCL-6 repression

2000 • 464 citations

Understanding the generation and function of memory T cell subsets

2005 • 459 citations

Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice

1996 • 456 citations

BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor.

1996 • 434 citations

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment

2005 • 379 citations

An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1

1996 • 375 citations

An alternative pathway for gene regulation by Myc

1997 • 365 citations

GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

2004 • 339 citations

All in the Family: the BTB/POZ, KRAB, and SCAN Domains

2001 • 338 citations

Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development

1998 • 325 citations

Biological roles and mechanistic actions of co-repressor complexes

2002 • 323 citations

The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT

1998 • 314 citations

Ensembl 2006

2005 • 309 citations

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development

2003 • 299 citations

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

1995 • 285 citations

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells

2004 • 284 citations

Mechanism of SMRT Corepressor Recruitment by the BCL6 BTB Domain

2003 • 283 citations

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

2005 • 256 citations

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

2002 • 244 citations

GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

2003 • 241 citations

Transcription

2002 • 241 citations

CD8+ T cells can be primed in vitro to produce IL-4.

1992 • 214 citations

Critical Residues within the BTB Domain of PLZF and Bcl-6 Modulate Interaction with Corepressors

2002 • 208 citations

Transcriptional repression by the proto-oncogene BCL-6.

1996 • 196 citations

Role for Bcl-6 in the generation and maintenance of memory CD8[+] T cells

2002 • 192 citations

In-Depth Mutational Analysis of the Promyelocytic Leukemia Zinc Finger BTB/POZ Domain Reveals Motifs and Residues Required for Biological and Transcriptional Functions

2000 • 184 citations

Differentiation of memory B and T cells

2006 • 175 citations

Co-operative DNA binding by GAGA transcription factor requires the conserved BTB/POZ domain and reorganizes promoter topology

1999 • 173 citations

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

2001 • 172 citations

The BACK domain in BTB-kelch proteins

2004 • 170 citations

Dual Functions of Runx Proteins for Reactivating CD8 and Silencing CD4 at the Commitment Process into CD8 Thymocytes

2005 • 160 citations

The CD8α Gene Locus Is Regulated by the Ikaros Family of Proteins

2002 • 149 citations

T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6

1998 • 148 citations

Bcl6 Acts as an Amplifier for the Generation and Proliferative Capacity of Central Memory CD8+ T Cells

2004 • 144 citations

ROG, Repressor of GATA, Regulates the Expression of Cytokine Genes

2000 • 139 citations

A Novel BTB/POZ Transcriptional Repressor Protein Interacts With the Fanconi Anemia Group C Protein and PLZF

1999 • 136 citations

Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors

1995 • 129 citations

CD4⁺ memory T cells: functional differentiation and homeostasis

2006 • 121 citations

A Combinatorial Code for Gene Expression Generated by Transcription Factor Bach2 and MAZR (MAZ-Related Factor) through the BTB/POZ Domain

2000 • 116 citations

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals

2004 • 109 citations

The N-terminal POZ Domain of GAGA Mediates the Formation of Oligomers That Bind DNA with High Affinity and Specificity

1999 • 108 citations

Negative regulation of CD8 expression via Cd8 enhancer–mediated recruitment of the zinc finger protein MAZR

2006 • 100 citations

Regulation of Lineage Commitment Distinct from Positive Selection

1999 • 98 citations

BAZF, a Novel Bcl6 Homolog, Functions as a Transcriptional Repressor

1998 • 85 citations

CD8 T Cell-Specific Downregulation of Histone Hyperacetylation and Gene Activation of the IL-4 Gene Locus by ROG, Repressor of GATA

2003 • 80 citations

Regulation of Lymphocyte Cell Fate Decisions and Lymphomagenesis by BCL-6

1999 • 78 citations

Identification and Characterization of DPZF, a Novel Human BTB/POZ Zinc Finger Protein Sharing Homology to BCL-6

2001 • 77 citations

BCL6b mediates the enhanced magnitude of the secondary response of memory CD8 ⁺ T lymphocytes

2005 • 77 citations

HD mice: A novel mouse mutant with a specific defect in the generation of CD4⁺T cells

1998 • 75 citations

c-Krox Binds to Several Sites in the Promoter of Both Mouse Type I Collagen Genes

1996 • 67 citations

The proto‐oncogene BCL‐6 in normal and malignant B cell development

2002 • 62 citations

Combined Deletion of CD8 Locus cis-Regulatory Elements Affects Initiation but Not Maintenance of CD8 Expression

2002 • 61 citations

A single peripheral CD8⁺T cell can give rise to progeny expressing type 1 and/or type 2 cytokine genes and can retain its multipotentiality through many cell divisions

1997 • 61 citations

Variegated Expression of CD8α Resulting from In Situ Deletion of Regulatory Sequences

2002 • 49 citations

Disruption of PLZP in Mice Leads to Increased T-Lymphocyte Proliferation, Cytokine Production, and Altered Hematopoietic Stem Cell Homeostasis

2004 • 48 citations

BCL-6 in the Pathogenesis of Non-Hodgkin's Lymphoma

2000 • 48 citations

Committed to memory: lineage choices for activated T cells

2006 • 45 citations

A new functional domain of Bcl6 family that recruits histone deacetylases

2001 • 44 citations

Binding of BAZF and Bc16 to STAT6-Binding DNA Sequences

2001 • 43 citations

Transcriptional repressor BCL-6 immortalizes germinal center-like B cells in the absence of p53 function

2004 • 42 citations

Role of the transcription factor Th‐POK in CD4:CD8 lineage commitment

2006 • 40 citations

The Zinc Finger Domain of Tzfp Binds to the tbs Motif Located at the Upstream Flanking Region of the Aie1(aurora-C) Kinase Gene

2001 • 38 citations

Functional and Molecular Analysis of the Double-Positive Stage-Specific CD8 Enhancer E8III during Thymocyte Development

2005 • 35 citations

ROG Negatively Regulates T-Cell Activation but Is Dispensable for Th-Cell Differentiation

2005 • 31 citations

Bcl6-dependent transcriptional repression by BAZF

2003 • 26 citations

BAZF is required for activation of naive CD4 T cells by TCR triggering

2004 • 20 citations

A Repressor of GATA-Mediated Negative Feedback Mechanism of T Cell Activation

2004 • 19 citations