Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells

2000 • 2,384 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses

2000 • 1,665 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

Crystal Structure of Mouse CD1: An MHC-Like Fold with a Large Hydrophobic Binding Groove

1997 • 629 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

STRUCTURAL BASIS OF T CELL RECOGNITION

1999 • 518 citations

Crystal structure of the complex between human CD8αα and HLA-A2

1997 • 471 citations

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1988 • 445 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

TCR Binding to Peptide-MHC Stabilizes a Flexible Recognition Interface

1999 • 306 citations

Critical Role for Cd8 in T Cell Receptor Binding and Activation by Peptide/Major Histocompatibility Complex Multimers

2000 • 281 citations

Dimeric association and segmental variability in the structure of human CD4

1997 • 266 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

Polymorphism in the α3 domain of HLA-A molecules affects binding to CD8

1989 • 247 citations

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

1995 • 245 citations

T Cell Receptor and Coreceptor CD8αα Bind Peptide-MHC Independently and with Distinct Kinetics

1999 • 194 citations

Structural Basis of CD8 Coreceptor Function Revealed by Crystallographic Analysis of a Murine CD8αα Ectodomain Fragment in Complex with H-2Kb

1998 • 185 citations

The Efficiency of CD4 Recruitment to Ligand-engaged TCR Controls the Agonist/Partial Agonist Properties of Peptide–MHC Molecule Ligands

1997 • 183 citations

Thermodynamics of T cell receptor binding to peptide–MHC: Evidence for a general mechanism of molecular scanning

1999 • 178 citations

CD2 and the nature of protein interactions mediating cell‐cell recognition

1998 • 153 citations

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.

1996 • 141 citations

Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling

1990 • 136 citations

Classical and Nonclassical Class I Major Histocompatibility Complex Molecules Exhibit Subtle Conformational Differences That Affect Binding to CD8αα

2000 • 136 citations

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.

1995 • 130 citations

Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts.

1991 • 128 citations

Killer Cell Immunoglobulin Receptors and T Cell Receptors Bind Peptide-Major Histocompatibility Complex Class I with Distinct Thermodynamic and Kinetic Properties

1999 • 122 citations

CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses?

1998 • 117 citations

Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 β chain

1994 • 115 citations

CD4 Augments the Response of a T Cell to Agonist but Not to Antagonist Ligands

1997 • 114 citations

Requirement for CD8 β Chain in Positive Selection of CD8-Lineage T Cells

1994 • 110 citations

Role of CD8β Domains in CD8 Coreceptor Function

2000 • 105 citations

The CD8 coreceptor revisited: One chain good, two chains better

1994 • 99 citations

Interaction between CD8 and major histocompatibility complex (MHC) class I mediated by multiple contact surfaces that include the alpha 2 and alpha 3 domains of MHC class I.

1995 • 96 citations

Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120.

1995 • 94 citations

CD8β Increases CD8 Coreceptor Function and Participation in TCR–Ligand Binding

1996 • 93 citations

Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells.

1992 • 93 citations

Expression, Purification, and Functional Analysis of Murine Ectodomain Fragments of CD8αα and CD8αβ Dimers

1999 • 88 citations

Co-engagement of CD8 with the T cell receptor is required for negative selection

1991 • 85 citations

Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.

1994 • 82 citations

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules

1991 • 81 citations

An immunological role for the CD8 β-chain

1992 • 76 citations

The two membrane proximal domains of CD4 interact with the T cell receptor.

1996 • 69 citations

A signaling role for the cytoplasmic segment of the CD8 alpha chain detected under limiting stimulatory conditions.

1990 • 64 citations

Thymic Selection of Cytotoxic T Cells Independent of CD8 α-Lck Association

1993 • 63 citations

The lack of CD8α cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8⁺ T lymphocytes

1993 • 52 citations

The role of charge and multiple faces of the CD8alpha/alpha homodimer in binding to major histocompatibility complex class Imolecules: support for a bivalent model.

1994 • 51 citations

Profound Enhancement of T Cell Activation Mediated by the Interaction Between the TCR and the D3 Domain of CD4

1999 • 51 citations

Beta-chain broadens range of CD8 recognition for MHC class I molecule.

1992 • 48 citations

Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade

1998 • 45 citations

Antagonism of cytotoxic T-lymphocyte activation by soluble CD8

1999 • 45 citations

The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development.

1998 • 44 citations

The Cytoplasmic Domain of CD8β Regulates Lck Kinase Activation and CD8 T Cell Development

1998 • 41 citations

Co-capping studies reveal CD8/TCR interactions after capping CD8β polypeptides and intracellular associations of CD8 with p56lck

1998 • 39 citations

Peptides corresponding to the CD8 and CD4 binding domains of HLA molecules block T lymphocyte immune responses in vitro.

1994 • 38 citations

The CD8β Ectodomain Contributes to the Augmented Coreceptor Function of CD8αβ Heterodimers Relative to CD8αα Homodimers

1999 • 36 citations

Orientation of the Ig domains of CD8 alpha beta relative to MHC class I.

1999 • 35 citations

Orientation of the Ig Domains of CD8αβ Relative to MHC Class I

1999 • 34 citations

Human CD8β, But Not Mouse CD8β, Can Be Expressed in the Absence of CD8α as a ββ Homodimer

2000 • 32 citations

Crystal structure of the complex between human CD8αα and HLA-A2

1998 • 31 citations

Interactions of HLA‐B*4801 with peptide and CD8

1997 • 27 citations

Assembly and crystallization of the complex between the human T cell coreceptor CD8α homodimer and HLA‐A2

1998 • 25 citations

A structure-based approach to designing synthetic CD8α peptides that can inhibit cytotoxic T-lymphocyte responses

1998 • 21 citations

Peptides corresponding to the CD8 binding region of HLA class I block the differentiation of cytotoxic T lymphocyte precursors.

1993 • 8 citations