The CD8β Ectodomain Contributes to the Augmented Coreceptor Function of CD8αβ Heterodimers Relative to CD8αα Homodimers

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

Crystal structure of the complex between human CD8αα and HLA-A2

1997 • 471 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

The isolation and sequence of the gene encoding T8: A molecule defining functional classes of T lymphocytes

1985 • 325 citations

Short Related Sequences in the Cytoplasmic Domains of CD4 and CD8 Mediate Binding to the Amino-Terminal Domain of the p56^lck Tyrosine Protein Kinase

1990 • 245 citations

Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes

1987 • 220 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

Thymus Independent T Cell Development and Selection in the Intestinal Epithelium

1994 • 197 citations

Inability of CD8α′polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo

1989 • 183 citations

Transfection of the CD8 gene enhances T-cell recognition

1987 • 177 citations

Role of CD4 and CD8 in T Cell Activation and Differentiation

1993 • 172 citations

Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule.

1990 • 164 citations

Expression of different CD8 isoforms on distinct human lymphocyte subpopulations

1991 • 159 citations

A second subunit of CD8 is expressed in human T cells.

1988 • 155 citations

Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase.

1990 • 145 citations

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA

1985 • 135 citations

Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 β chain

1994 • 115 citations

Requirement for CD8 β Chain in Positive Selection of CD8-Lineage T Cells

1994 • 110 citations

Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression.

1988 • 101 citations

Interaction between CD8 and major histocompatibility complex (MHC) class I mediated by multiple contact surfaces that include the alpha 2 and alpha 3 domains of MHC class I.

1995 • 96 citations

CD8β Increases CD8 Coreceptor Function and Participation in TCR–Ligand Binding

1996 • 93 citations

Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity.

1991 • 92 citations

The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses.

1988 • 88 citations

Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.

1994 • 82 citations

Association of CD8 with p56lck is required for early T cell signalling events.

1991 • 79 citations

An immunological role for the CD8 β-chain

1992 • 76 citations

A role for the cytoplasmic tail of the β chain of CD8 in thymic selection

1994 • 70 citations

The human Lyt-3 molecule requires CD8 for cell surface expression.

1988 • 65 citations

A signaling role for the cytoplasmic segment of the CD8 alpha chain detected under limiting stimulatory conditions.

1990 • 64 citations

CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity.

1995 • 57 citations

The lack of CD8α cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8⁺ T lymphocytes

1993 • 52 citations

The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development.

1998 • 44 citations

Topology of T cell receptor-peptide/class I MHC interaction defined by charge reversal complementation and functional analysis

1997 • 41 citations

Diversity of T cell receptors specific for the VSV antigenic peptide (N52-59) Bound by the H-2Kb class I molecule

1995 • 41 citations

The Cytoplasmic Domain of CD8β Regulates Lck Kinase Activation and CD8 T Cell Development

1998 • 41 citations

Molecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T-cell receptor variable and joining regions.

1987 • 36 citations

The CD4/CD8:p56^lck complex in T lymphocytes: a potential mechanism to regulate T-cell growth

1989 • 25 citations

The CD8β polypeptide is required for the recognition of an altered peptide ligand as an agonist

1996 • 21 citations

Mechanisms of CD8beta-mediated T cell response enhancement: interaction with MHC class I/beta2-microglobulin and functional coupling to TCR/CD3.

1998 • 20 citations

Mechanisms of CD8β-Mediated T Cell Response Enhancement: Interaction with MHC Class I/β2-Microglobulin and Functional Coupling to TCR/CD3

1998 • 17 citations