Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

LAT

1998 • 1,251 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

1990 • 775 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand

1991 • 565 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

Complex Complexes: Signaling at the TCR

1996 • 512 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

1988 • 447 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1993 • 414 citations

Kinetic discrimination in T-cell activation.

1996 • 286 citations

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.

1993 • 271 citations

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.

1993 • 266 citations

Post-menopausal oestrogen therapy.

1999 • 257 citations

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

1994 • 254 citations

A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells.

1994 • 246 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

GRB2 and Phospholipase C-7γ1 Associate with a 36- to 38-Kilodalton Phosphotyrosine Protein after T-Cell Receptor Stimulation

1994 • 181 citations

Th2 cell clonal anergy as a consequence of partial activation.

1994 • 175 citations

Altered T Cell Receptor Ligands Trigger a Subset of Early T Cell Signals

1996 • 169 citations

Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides.

1993 • 166 citations

Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase.

1995 • 158 citations

SELECTIVE TRANSFORMATION OF B LYMPHOCYTES BY E.B. VIRUS

1973 • 147 citations

Ligands for the T-cell receptor: hard times for avidity models

1995 • 138 citations

Killer Cell Inhibitory Receptor Recognition of Human Leukocyte Antigen (HLA) Class I Blocks Formation of a pp36/PLC-γ Signaling Complex in Human Natural Killer (NK) Cells

1996 • 133 citations

T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

1994 • 123 citations

Partial signaling by CD8+ T cells in response to antagonist ligands.

1996 • 111 citations

Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus

1997 • 108 citations

Cytotoxic T Lymphocyte Lysis Inhibited by Viable HIV Mutants

1995 • 107 citations

Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) zeta subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR zeta.

1993 • 91 citations

Molecular recognition of antigen involves lattice formation between CD4, MHC class II and TCR molecules

1995 • 85 citations

Characterization of Lnk

1997 • 77 citations

Lymphocyte lineage-restricted tyrosine-phosphorylated proteins that bind PLC gamma 1 SH2 domains.

1992 • 75 citations

The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus

1995 • 74 citations

Antagonism of cytotoxic T lymphocyte‐mediated lysis by natural HIV‐1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides

1997 • 69 citations

Ligation of the T-cell Antigen Receptor (TCR) Induces Association of hSos1, ZAP-70, Phospolipase C-γ1, and Other Phosphoproteins with Grb2 and the ζ-Chain of the TCR

1995 • 66 citations

Understanding the Mechanisms of Sustained Signaling and T Cell Activation

1997 • 60 citations

Altered Hapten Ligands Antagonize Trinitrophenyl-specific Cytotoxic T Cells and Block Internalization of Hapten-specific Receptors

1997 • 50 citations

A disease-related epitope of Torpedo acetylcholine receptor. Residues involved in I-Ab binding, self-nonself discrimination, and TCR antagonism.

1994 • 47 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells Bertoletti A, Sette A, Chisari FV, Penna A, Levrero M, DeCarli M, Ficaccadori F, et al Nature 1994; 369: 407?410

1995 • 39 citations

Constitutive Tyrosine Phosphorylation of the T-Cell Receptor (TCR) ζ Subunit: Regulation of TCR-Associated Protein Tyrosine Kinase Activity by TCR ζ

1993 • 36 citations