The Cholera Toxin B Subunit is a Mucosal Adjuvant for Oral Tolerance Induction in Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Immune responses to dietary antigens: oral tolerance

1998 • 462 citations

Activation of CD25+CD4+ Regulatory T Cells by Oral Antigen Administration

2001 • 458 citations

Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen

2001 • 429 citations

Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding.

1994 • 318 citations

Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance.

1994 • 317 citations

Pancreatic Lymph Node-Derived CD4+CD25+ Treg Cells

2002 • 312 citations

Tumor necrosis factor-α regulation of CD4⁺C25⁺T cell levels in NOD mice

2002 • 252 citations

Oral insulin administration and residual (β-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial

2000 • 239 citations

A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes

1997 • 231 citations

IL-4 is a differentiation factor for transforming growth factor-β secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis

1998 • 218 citations

No effect of oral insulin on residual beta-cell function in recent-onset Type I diabetes (the IMDIAB VII)

2000 • 211 citations

Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit.

1996 • 198 citations

Autoreactive CD4+ T Cells Protect from Autoimmune Diabetes via Bystander Suppression Using the IL-4/Stat6 Pathway

1999 • 184 citations

Cholera Toxin B Subunit as a Carrier Molecule Promotes Antigen Presentation and Increases CD40 and CD86 Expression on Antigen-Presenting Cells

2001 • 164 citations

Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4+ regulatory T-cells.

1999 • 89 citations

Oral tolerance in disease

1999 • 88 citations

Insulin-dependent diabetes mellitus and its animal models

1999 • 78 citations

Insulin in Oral Immune “Tolerance”: A One-Amino Acid Change in the B Chain Makes the Difference

1999 • 78 citations

Cyclic AMP-independent effects of cholera toxin on B cell activation. II. Binding of ganglioside GM1 induces B cell activation.

1992 • 74 citations

Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells.

1999 • 69 citations

Prolonged oral treatment with low doses of allergen conjugated to cholera toxin B subunit suppresses immunoglobulin E antibody responses in sensitized mice

2000 • 65 citations

Oral Administration of Recombinant Cholera Toxin Subunit B Inhibits IL-12-Mediated Murine Experimental (Trinitrobenzene Sulfonic Acid) Colitis

2001 • 61 citations

Oral tolerance in the treatment of inflammatory autoimmune diseases

1999 • 58 citations

Immunomodulation of Experimental Autoimmune Diseases via Oral Tolerance

2000 • 50 citations

Selective tolerization of Th1-like cells after nasal administration of a cholera toxoid-LACK conjugate

1998 • 47 citations

Ligation of MHC class I molecules on peripheral blood T lymphocytes induces new phenotypes and functions.

1996 • 46 citations

Modulation of oral tolerance to ovalbumin by cholera toxin and its B subunit

1992 • 44 citations

Cholera toxin B subunit binding to an antigen-presenting cell directly co-stimulates cytokine production from a T cell clone

1996 • 41 citations

The initiation of autoimmune diabetes

1999 • 38 citations

Restoration of self-tolerance is a feasible approach to control ongoing beta-cell specific autoreactivity: its relevance for treatment in established diabetes and islet transplantation

2001 • 26 citations

Differential Induction of Programmed Cell Death in CD8+and CD4+T Cells by the B Subunit of Cholera Toxin

1996 • 24 citations

Enhanced Immunological Tolerance against Allograft Rejection by Oral Administration of Allogeneic Antigen Linked to Cholera Toxin B Subunit

2000 • 24 citations

Induction of Tolerance in Macrophages by Cholera Toxin B Chain

1999 • 14 citations

A New Model for Analyzing Immunomodulation of T Cell Responses Induced by Oral Administration of Islet Cell Antigens

2002 • 3 citations

Generation and effector functions of regulatory lymphocytes

2002 • 1 citations